张俊华 - 中科院数学与系统科学研究院 -

个人简介

JunhuaZhangreceivedherPh.D.degreeinoperationalresearchandcyberneticsfromtheInstituteofSystemsScience,ChineseAcademyofSciences(CAS),Beijing,China,in1995.NowsheisanassociateprofessorattheInstituteofAppliedMathematics,AcademyofMathematicsandSystemsScience,CAS. Dr.ZhangisaresearchfellowatCenterofBioinformatics,AcademyofMathematicsandSystemsScience,CAS;NationalCenterforMathematicsandInterdisciplinarySciences,CAS;andKeyLaboratoryofRandomComplexStructuresandDataScience,CAS.Sheisareviewerofmanyinternationaljournals,includingCancerResearch,ScientificReports,Bioinformatics,PLOSComputationalBiology,InformationSciences,MolecularBioSystems,Oncotarget,PhysicaA,BMCSystBiol,ModPhysLettB,etc. Dr.Zhanghasworkedonproblemsinprobabilitytheory,stochasticapproximationanditsapplications,featureextractioninpatternrecognition,informationmeasuresandtheirapplications.Hercurrentresearchinterestsincludecomputationalsystemsbiology,dataminingandnetworkscience.

研究领域

CancerGenomics Understandingthemechanismofcarcinogenesishasbeenagreatchallengeforhuman.Withtherapidadvanceindeepsequencingtechnologies,severallarge-scalecancerprojectshavegeneratedanunprecedentedamountofcancergenomicsdata,whichhasprovidedtremendousopportunitiesforthebetterunderstandingoncancerinitiation,progressionanddevelopment.Decipheringthosedataposesgreatchallengesandcomputationalproblemsforthecommunityofbioinformaticsandcomputationalbiology.Oneofsuchkeychallengesistodistinguishdrivermutations,genesaswellaspathwaysfrompassengerones.Wemainlyaimtodevelopcomputationalmethods(modelsandalgorithms)toidentifycancerdrivergenesorpathwaystoenhanceunderstandingforcarcinogenesis. NetworkScience Manyreal-worldsystemscanberepresentedbynetworkscomposedofverticesandedges,suchasbiologicalnetworks,socialnetworks,etc.Usuallythefunctionsofthesystemsarecloselyrelatedtothenetworkstructures(inbiology,networkmedicine).Weaimtodevelopmodelsandalgorithmstouncoverthetopologicalorganizationofcomplexnetworkstobetterunderstandthemechanismsunderlyingcomplexdiseases,biologicalsystemsandothercomplexsystems.Amongothers,communitystructuredetectionofcomplexnetworksattractsagreatdealofattentioninvariousdisciplines,whichmeansthedivisionofnetworksintogroups(alsocalledclusters)havingdenseintraconnections,andsparseinterconnections. InformationMeasures Informationmeasures,suchasShannonentropy,mutualinformation,Kullback–Leiblerinformation,etc.,arequantitiesmeasuringtheinformationaboutrandomoutcomeswhicharedescribedbyprobabilitydistributions.Wemainlyfocusedonproposingsomenewinformationmeasures,andthenanalyzingtheirpropertiesandapplyingthemtootherdisciplines. StochasticApproximation Stochasticapproximation(SA)methodsareafamilyofiterativestochasticoptimizationalgorithmsthatattempttofindzeroesorextremaoffunctionswhichcannotbecomputeddirectly,butonlyestimatedvianoisyobservations.WefocusedontheconvergenceanalysisofsomeSAalgorithms,andontheapplicationresearchofSAtootherdisciplinessuchaspatternrecognitionandfeatureextractions.

近期论文

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SelectedPublications(*correspondenceauthor)--BookChapters JunhuaZhang*,ShihuaZhang,Modularorganizationofgeneregulatorynetworks.W.Dubitzky,O.Wolkenhauer,K.-H.Cho,H.Yokota(eds.),EncyclopediaofSystemsBiology(2013),SpringerScience+BusinessMediaLLC,pp.1437-1441 JunhuaZhang*,Hub;Dynamicmodularity;Modulenetwork.W.Dubitzky,O.Wolkenhauer,K.-H.Cho,H.Yokota(eds.),EncyclopediaofSystemsBiology(2013),SpringerScience+BusinessMediaLLC,pp.629,926-927,1446-1447 SelectedJournalPapers(*correspondenceauthor) JunhuaZhang*andShihuaZhang*,Discoveryofcancercommonandspecificdrivergenesets.NucleicAcidsRes.(2017),45(10):e86 JunhuaZhangandShihuaZhang,Thediscoveryofmutateddriverpathwaysincancer:modelsandalgorithms.IEEE/ACMTrans.Comput.Biol.Bioinform.(2016),doi:10.1109/TCBB.2016.2640963 JunhuaZhang*,Ling-YunWu,Xiang-SunZhangandShihuaZhang*,Discoveryofco-occurringdriverpathwaysincancer.BMCBioinformatics(2014),15:271(HighlyAccessed) JunhuaZhang*,ShihuaZhang*,YongWangandXiang-SunZhang,Identificationofmutatedcorecancermodulesbyintegratingsomaticmutation,copynumbervariation,andgeneexpressiondata.BMCSystemsBiology(2013),7:S4 Hui-JiaLi,JunhuaZhang,Zhi-PingLiu,LuonanChenandXiang-SunZhang,Identifyingoverlappingcommunitiesinsocialnetworksusingmulti-scalelocalinformationexpansion.Eur.Phys.J.B(2012),85:190 Hui-JiaLi,YongWang,Ling-YunWu,JunhuaZhangandXiang-SunZhang,PottsmodelbasedonaMarkovprocesscomputationsolvesthecommunitystructureproblemeffectively.PhysicalReviewE(2012),86:016109 JunhuaZhang*,YuqingQiuandXiang-SunZhang,Detectingcommunitystructure:fromparsimonytoweightedparsimony.JournalofSystemsScienceandComplexity(2010),23:1024-1036 JunhuaZhang*,ShihuaZhangandXiang-SunZhang,Detectingcommunitystructureincomplexnetworksbasedonameasureofinformationdiscrepancy.PhysicaA(2008),387:1675-1682 MinZhang,WeiwuFang,JunhuaZhangandZhongxianChi,MSAID:MultipleSequenceAlignmentBasedonaMeasureofInformationDiscrepancy.ComputationalBiologyandChemistry(2005),29:175-181 JunhuaZhangandWeiwuFang,Anewapproachofinformationdiscrepancytoanalysisofquestionnairedata.CommunicationsinStatistics–TheoryandMethods(2003),32:435-457 ShihuaChen,JunhuaZhangandToddYoung,Existenceofpositiveperiodicsolutionfornonautonomouspredator-preysystemwithdiffusionandtimedelay.JournalofComputationalandAppliedMathematics(2003),159:375-386 JunhuaZhang*,OnLyapunovfunctionsinstochasticapproximation.MathematicaApplicata(2001),14:56-60 JunhuaZhangandWeiwuFang,Anewstatisticforvariableselectioninquestionnaireanalysis,J.Syst.Sci.Syst.Eng.(2001),10:315-322 JunhuaZhang*,Convergenceofalgorithmsforfindingeigenvectors.ActaMathematicaeApplicataeSinica(EnglishSeries)(2000),16:355-361 JunhuaZhangandHanfuChen,Convergenceofalgorithmsusedforprincipalcomponentanalysis.ScienceinChina(SeriesE)(EnglishSeries)(1997),40:597-604 SelectedConferencePapers(*correspondenceauthor) JunhuaZhang*,ShihuaZhang*,YongWang,JunfeiZhaoandXiang-SunZhang,Identifyingmutatedcoremodulesinglioblastomabyintegrativenetworkanalysis.ProceedingsofIEEE6thInternationalConferenceonSystemsBiology(2012),304-309 JunhuaZhang*,Zhi-PingLiu,Xiang-SunZhangandLuonanChen,Adynamicalmethodtoextractcommunitiesinducedbylowormiddle-degreenodes.ProceedingsofIEEE5thInternationalConferenceonSystemsBiology(2011),340-344 ShoujunXu,JiguangWang,JunhuaZhangandXiang-XunZhang,Multipleresolutioncommunitystructureanalysis.LectureNotesinOperationsResearch14:OperationsResearchandItsApplications(2011),334-349 JunhuaZhang*andXiang-SunZhang,Onresolutionlimitofthemodularityincommunitydetection.LectureNotesinOperationsResearch12:OperationsResearchandItsApplications(2010),492-499 JunhuaZhang,WentaoHuang,ZhiyuanZhao,BiaoLi,YuelanWang,DongfengGu,GuoyingLi,andRenshengChen,Studyonmultilocusinteractionsforhypertensionbyaninformationtheoreticmethod.LectureNotesinOperationsResearch11:OptimizationandSystemsBiology(2009),456-467 JunhuaZhang*andXiang-SunZhang,Aweightedparsimonymodelforcommunitydetectionincomplexnetworks.LectureNotesinOperationsResearch11:OptimizationandSystemsBiology(2009),419-429 JunhuaZhang*andShihuaChen,Arandomiterativealgorithmforcommunitydetection.LectureNotesinOperationsResearch11:OptimizationandSystemsBiology(2009),448-455 JunhuaZhang*,ShihuaZhangandXiang-SunZhang,Comparativestudyonaclassofevaluationindicesforcommunitydetection.LectureNotesinOperationsResearch9:OptimizationandSystemsBiology(2008),294-303 JunhuaZhang*,WeihuaYue,andXiang-SunZhang,Multilocusanalysisofcasecontroldatatoschizophreniabasedonmeasuresofinformationdiscrepancy.LectureNotesinOperationsResearch8:OperationsResearchandItsApplications(2008),432-439 JunhuaZhangandWeiwuFang,Asymptoticdistributionsofameasureofinformationdiscrepancyamongmultiplediscretedistributions.ProceedingsofORSC,HongKong:Global-LinkPublishingCompany(2004),1278-1787