Gross, Michael L. - George Washington University

个人简介

B.A. (Cum Laude) Chemistry, St. John's Univ. (Minn.), 1962- Ph.D., Organic Chemistry, Univ. of Minnesota 1966 Dissertation Title: "Reactivity of Electron-Rich Aromatics" Postdoctoral, U. of Penn. (E.R. Thornton), 1966-67 (one year) Postdoctoral, Purdue Univ. (F.W. McLafferty), 1967-68 (one year)

研究领域

Analytical Chemistry Biological Chemistry Biophysical Chemistry Mass Spectrometry-Based Protein Biochemistry and Biophysics Protein Footprinting Proteomics

近期论文

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Deamidation Slows Curli Amyloid-Protein Aggregation, Hanliu Wang, Qin Shu, Carl Frieden, Michael L. Gross, Biochemistry, 56, 2865-2872 (2017). PMC5644351 A Molecular Mechanism for Nonphotochemical Quenching in Cyanobacteria, Yue Lu, Haijun Liu, Rafael Saer, Veronica L. Li, Hao Zhang, Liuqing Shi, Carrie Goodson, Michael L. Gross, and Robert E. Blankenship, Biochemistry, 56, 2812-2823 (2017). PMC5623595 HDX MS reveals calcium binding properties and allosteric regulation of downstream regulatory element antagonist modulator (DREAM), Jun Zhang, Jing Li, Theodore Craig, Rajiv Kumar and Michael L. Gross, Biochemistry, 56, 3523–3530 (2017). PMC5551683 Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL‑6 Receptor upon Binding of Protein Therapeutics, Ke Sherry Li, Guodong Chen, Jingjie Mo, Richard Y.-C. Huang, Ekaterina G. Deyanova, Brett R. Beno, Steve R. O’Neil, Adrienne A. Tymiak, and Michael L. Gross, Anal. Chem., 89, 7742–7749(2017). PMC5549780 Peptide-Level Interactions between Proteins and Small-Molecule Drug Candidates by Two Hydrogen−Deuterium Exchange MS-Based Methods: The Example of Apolipoprotein E3, Hanliu Wang, Don L. Rempel, Daryl Giblin, Carl Frieden, and Michael L. Gross, Anal.Chem. 89, 10687–10695 (2017). PMC5655995 Native Mass Spectrometry, Ion mobility, and Collision-Induced Categorize Malaria Antigen/Antibody Binding, Yining Huang, Nichole D. Salinas, Edwin Chen, Niraj H. Tolia,and Michael L. Gross, J. Amer. Soc. Mass Spectrom., 28, 2515-2518 (2017). PMC5647250 Laser-initiated Radical Trifluoromethylation of Peptides and Proteins and Its Application to Mass Spectrometry-Based Protein Footprinting, Ming Cheng, Bojie Zhang, Weidong Cui, and Michael L. Gross, Angewandte Chemie-International Edition, 56, 14007-14010 (2017). PMC5663992 Reactive oxygen species leave a damage trail that reveals water channels in Photosystem II. D. A. Weisz, M. L. Gross, and H. B. Pakrasi, Sci. Adv., 3, eaao3013 (2017). PMC5693562 Mass spectral studies of the biologically active stereoisomer family of e,e,e- (methanofullerene(60-63)-carboxylic acids, Michael Grayson, Joshua Hardt, Michael Gross, Subhasish K. Chakraborty, Laura Dugan, Current Anal. Chem., 14, 1-10 (2018) Membrane Protein Structure in Live Cells: Methodology for Studying Drug Interaction by Mass Spectrometry-Based Footprinting, Guomin Shen, Shuang Li, Weidong Cui, Shixuan Liu, Yihu Yang, Michael Gross, and Weikai Li, Biochemistry, 57, 286–294 (2018). PMC5862532 Mouse and human monoclonal antibodies protect against infection by multiple genotypes of Japanese encephalitis virus, E. Fernandez, N. Kose, M.A. Edeling, J. Adhikari, G. Sapparapu,S.M. Lazarte, C.A. Nelson, J. Govero, Michael L. Gross, Daved H. Fremont, J.E. Crowe, Jr,Michael S. Diamond MS. mBio 9, e00008-18. https://doi.org/10.1128/mBio.00008-18(2018). PMC5829823 Human IFIT3 modulates IFIT1 1 RNA binding specificity and protein stability, Britney Johnson, L.A. VanBlargan, Wei Xu, J.P. White, Chao Shan, Pei-Yong Shi, Rong Zhang, Jagat Adhikari, Michael L. Gross, Daisy W. Leung, Michael S. Diamond, and Gaya K.Amarasinghe, Immunity, 48, 487-499 (2018). Mass Spectrometry-Based Fast Photochemical Oxidation of Proteins (FPOP) for Higher Order Structure Characterization, Ke Sherry Li, Liuqing Shi, and Michael L. Gross, Accounts of Chemical Research, 51, 736-744 (2018). PMC5936467 Primary and higher order structure of the reaction center from the purple phototrophic bacterium Blastochloris viridis: A test for native mass spectrometry, Yue Lu, Carrie Goodson, Robert E. Blankenship, Michael L. Gross, J. Proteome Research, 17, 4, 1615-1623(2018). PMC5911391 Pulsed HDX Illuminates the Aggregation Kinetics of Alpha-Synuclein, the Causative Agent for Parkinson’s Disease, Eva Illes-Toth, Don Rempel, and Michael L. Gross, ACS Chem Neuroscience, 9, 1469-1476 (2018). PMC6013392 Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen/Deuterium Exchange, Britney Johnson, Patrick McConnell, Alex G. Kozlov, Marlene Mekel, Timothy M. Lohman, Michael L. Gross, Gaya K. Amarasinghe, and John A. Cooper, Cell-Reports, 23, 2795-2804 (2018). Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Z. Su, C. Wu, L. Shi, P. Luthra, G.D. Pintilie, B. Johnson, J.R.Porter, P. Ge, M. Chen, G. Liu, T.E. Frederick, J.M. Binning, G.R. Bowman, Z.H. Zhou,C.F. Basler, Michael L. Gross, D. W. Leung, W. Chiu, and G.K. Amarasinghe, Cell, 172, 966-978 (2018). PMC5973842 Stabilization of warfarin‐binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition, G. Shen, S. Li, W. Cui, S. Liu,Q. Liu, Y. Yang, Michael Gross, Weikai Li, J. Thrombosis and Haemostasis, 16, 1164-1175(2018). Implementing Fast Photochemical Oxidation of Proteins (FPOP) as a Footprinting Approach to Solve Diverse Problems in Structural Biology, Bojie Zhang, Ming Cheng, Don Rempel, and Michael L. Gross, Methods, 144, 94-103 (2018) MRI is a DNA Damage Response Adaptor during Classical Non-Homologous End Joining, Putzer J. Hung, Britney Johnson, Bo-Ruei Chen, Andrea K. Byrum, Andrea L. Bredemeyer, William T. Yewdell, Tanya E. Johnson, Brian J. Lee, Shruthi Deivasigamani, Issa Hindi, Parmeshwar Amatya, Michael L. Gross, Tanya T. Paull, David J. Pisapia1, Jayanta Chaudhuri, John J. H. Petrini, Nima Mosammaparast, Gaya K. Amarasing