个人简介
胡贞贞博士
南昌大学基础医学院副教授、硕士生导师
教育和工作背景:
2004赣南医学院临床医学专业学士
2007中山大学医学院病理生理学硕士
2012韩国忠北国立大学药学专业博士
2017-2018中国科学院上海神经科学研究所访问学者
2017-至今南昌大学基础医学院副教授、硕士生导师从而为临床
治疗相关神经精神疾病,如药物成瘾,老年痴呆,帕金森等疾病提供新的思
路。近年来研究成果发表在本领域的国际期刊:BehaviouralPharmacology,
Neurochemistryinternational,BrainResearch,PLoSOne,FrontCell
Neurosci.,JournalofNeurochemistry等所获项目、荣誉、奖励及参加学术团体的情况:
1.神经科学国家重点实验室开放课题,SKLN-201701,基于GABA能神经元
GABABR转运上膜的可卡因成瘾分子机制,2018.1-2018.12,5万元,在研,
主持
2.江西省自然科学青年基金重点项目,20171ACB21002,伏隔核CART活性
肽治疗毒品成瘾的作用及机制研究,2017.1-2019.12,20万元,在研,主持
3.江西省自然科学基金一般项目,20161BBG70065,CART基因应用于抑郁症
诊断和治疗及机制研究,2016.1-2018.12,5万元,在研,主持
4.江西省卫生厅青年项目,2015A041,酸枣仁汤对原发性失眠和抑郁症失
眠的治疗及机制研究,0.4万元,在研,主持
5.国家自然科学基金青年基金项目,81201035,伏隔核CART通过钙离子调
节CaMK-D3R负反馈调节可卡因奖赏效应,2013/01-2015/12,23万元,已
结题,主持
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
1XiongL,MengQ,SunX,LuX,FuQ,PengQ,YangJ,OhKW,HuZ
#
.CART
peptideinthenucleusaccumbensshellinhibitscocaine-inducedlocomotor
sensitizationtotransientoverexpressionofα-Ca2+/Calmodulin-dependent
ProteinKinaseII.JNeurochem.2018Jan4.doi:10.1111/jnc.14289.(#
Correspondingauthor)
2HuQ,HuZ,ChenQ,HuangY,MaoZ,XuF,ZhouX.BML-111equilibrated
ACE-AngII-AT1RandACE2-Ang-(1-7)-Masaxistoprotecthepaticfibrosisin
rats.ProstaglandinsOtherLipidMediat.2017Jul;131:75-82.doi:
10.1016/j.prostaglandins.2017.08.008.3YuC,ZhouX,FuQ,PengQ,OhKW,HuZ#
.ANewInsightintotheRoleof
CARTinCocaineReward:InvolvementofCaMKIIandInhibitoryG-Protein
CoupledReceptorSignaling.FrontCellNeurosci.2017Aug15;11:244.doi:
10.3389/fncel.(
#CorrespondingAuthor)
4FuQ,ZhouXY,DongY,HuangYH,YangJH,OhKW,andHuZ#
.Decreased
Caffeine-InducedLocomotorActivityviaMicroinjectionofCARTPeptideinto
theNucleusAccumbensIsLinkedtoInhibitionofthepCaMKIIa-D3R
Interaction.2016,PLoSOne11:e0159104(
#CorrespondingAuthor)
5HuZZ,OhEH,ChungYB,HongJT,andOhKW.PredominantD1Receptors
InvolvementintheOver-expressionofCARTPeptidesafterRepeatedCocaine
Administration。2015,KoreanJPhysiolPharmacol19:89-97
6PengQH,SunX,LiuZY,YangJH,OhKW,andHuZ#
.Microinjectionof
CART(cocaine-andamphetamine-regulatedtranscript)peptideintothenucleus
accumbensinhibitsthecocaine-inducedupregulationofdopaminereceptorsand
locomotorsensitization.2014.Neurochemistryinternational75:105-111.(
#
CorrespondingAuthor)
7CaiZY,ZhangDL,YingY,YanM,YangJH,XuFY,OhKW,andHuZ#
.InhibitoryModulationofCARTPeptidesinAccumbalneuronthrough
DecreasingInteractionofCaMKIIαwithDopamineD3receptors.2014.Brain
Research1557:101-110.(#CorrespondingAuthor)
8HuZZ,LeeCII,HanJY,OhEH,RyuJH,HongJT,KimYSandOhKW.Caffeineinducesbehaviouralsensitizationandoverexpressionof
cocaine-regulatedandamphetamine-regulatedtranscriptpeptidesinmice(2014).BehaviouralPharmacology25:32-43.9HuZZ,LeeChung-II,ShahVikashKumar,OhEun-Hye,HanJin-Yi,Bae
Jae-Ryong,LeeKinam,Chongyong-Soo,HongJinTae,andOhKi-Wan.CordycepinIncreasesNonrapidEyeMovementSleepviaAdenosineReceptorsin
Rats(2013).Evid-BasedComplementAlternatMed.2013:1-8
10HuZZ,Park,K.S.,Han,J.Y.etal.Markersinmophine-andcocaine-addictedanimals(2011).BiomolTher,19:52-54