张大雷 - 南昌大学 - 基础医学院

个人简介

张大雷博士南昌大学基础医学院教授基础医学、生物学硕士生导师临床病理与病理生理学博士生导师 教育和工作背景: 2007毕业于浙江大学获博士学位 2007-2011南昌大学基础医学院讲师 2011-2016南昌大学基础医学院副教授 2016-至今南昌大学基础医学院教授、博士生导师近年来主持国家自然科学基金、江西省自然科学基金及江西省教育厅科技项目等多项科研项目，在国际学术期刊上发表SCI收录论文20余篇。近年来所获科研项目： 1.国家自然科学基金“PFOA诱导睾丸生殖细胞毒性损伤的机制及Nrf2的调控作用研究”，2016.1-2019.12，81560248，主持。 2.国家自然科学基金“Nrf2-ARE系统调控环境内分泌干扰物引起的精原细胞毒性损伤的研究”2011.1-2013.12，81060056，主持。 3.江西省自然科学基金“Nrf2调控PFOA诱导的睾丸生殖毒性损伤的研究”， 2016.1-2018.12，20161BAB205208，主持。 4.江西省教育厅科技项目“内分泌干扰物诱导精原细胞氧化损伤及其修复机制的研究”，2012.1-2014.12，GJJ12083，主持。 5.江西省教育厅科技项目“人参皂甙对雄性生殖细胞发育调控的研究”， 20109.1-2011.12，主持。 6.国家自然科学基金“雌性骨髓间充质干细胞悬滴培养形成卵泡样结构和产生性激素的研究”，2010.1-2013.12，30960409，排名第三。 7.国家自然科学基金“甲状旁腺全切除后骨髓细胞甲状旁腺素的合成和调节研究”，2016.1-2019.12，2015年立项，81502417，在研，排名第二。

研究领域

生殖生理与病理；体外配子发生；肝脏、生殖与发育毒理及其调控。

近期论文

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DaleiZhang,YalingWu,YangyangYuan,WenwenLiu,Haibin,Kuang,Jianhua Yang,BeiYang,LeiWu,WeiyingZou,ChangshuiXu.Exposureto2,4-dichlorophenoxyaceticacidinducesoxidativestressandapoptosisinmouse testis.PesticideBiochemistryandPhysiology,2017,141:18-22 2.YuanY,GeS,LvZ,WuM,KuangH,YangB,WuLei,ZhangD*.Attenuation ofperfluorooctanoicacid-inducedtesticularoxidativestressandapoptosisby quercetininmice.RSCAdvances,2017,7(71),45045-45052 3.MoLi,YifanJia,YanLing,YiluChen,LuZhang,DanLuo,LidanLai,Meijun Guo,DaleiZhang,MinRen,HongXu,HaibinKuang.Reducedexpressionof folliclestimulatinghormonereceptormRNAandproteininpregnancies complicatedbypre-eclampsia.Molecularmedicinereports,2017,16(1),367-372.4.WenwenLiu,ChangshuiXu,XiSun,HaibinKuang,XiaodongKuang,Weiying Zou,BeiYang,LeiWu,FangmingLiu,TingZou,DaleiZhang*.Grapeseed proanthocyanidinextractprotectsagainstperfluorooctanoicacid-induced hepatotoxicitybyattenuatinginflammatoryresponse,oxidativestressand apoptosisinmice.ToxicologyResearch,2016,5:224-234.5.ZouWeiying,LinHua,LiuWenwen,YangBei,WuLei,DuanLimin,LingPing,ZhuLingyan,DaiQun,ZhaoLintong,ZouTing,DaleiZhang*.Moxibustion relievesvisceralhyperalgesiaviainhibitionoftransientreceptorpotential vanilloid1(TRPV1)andheatshockprotein(HSP)70expressioninratbone marrowcells.AcupunctMed,2016,34(2):114-119.6.ChenYilu,ZhouLing,XuJingjie,Zhang,Lu,LiMo,XieXingxing,XieYajuan,LuoDan,ZhangDalei,YuXiaochun,YangBei,KuangHaibin.Maternal exposuretoperfluorooctanoicacidinhibitslutealfunctionviaoxidativestressand apoptosisinpregnantmice.ReprodToxicol,2017,69:159-166.7.QinShanshan,ChenQiang,WuHui,LiuChenglong,HuJing,ZhangDalei,Xu Changshui.Effectsofnaringinonlearningandmemorydysfunctioninducedby gp120inrats.BrainResBull,2016,124:164-171.8.WenwenLiu,BeiYang,LeiWu,WeiyingZou,XiaolingPan,TingZou,Liping Xia,DaleiZhang*.InvolvementofNRF2inPerfluorooctanoicAcid-Induced TesticularDamageinMaleMice.BiologyofReproduction.2015,93,41:1-7.9.WeiyingZou,WenwenLiu,BeiYang,LeiWu,JianhuaYang,TingZou,Liping Xia,DaleiZhang*.Quercetinprotectsagainstperfluorooctanoicacid-induced liverinjurybyattenuatingoxidativestressandinflammatoryresponseinmice.InternationalImmunopharmacology.2015,28:129-135.10.XuJingjie,LiMo,ZhangLu,XiongHao,LaiLidan,GuoMeijun,ZongTeng,ZhangDalei,YangBei,WuLei,TangMin,KuangHaibin*.Expressionand regulationofandrogenreceptorinthemouseuterusduringearlypregnancyand decidualization.MolReprodDev,2015,82(11):898-906.11.ZongTeng,LaiLidan,HuJia,GuoMeijun,LiMo,ZhangLu,ZhongChengxue,YangBei,WuLei,ZhangDalei,TangMin,KuangHaibin*.Maternalexposure todi-(2-ethylhexyl)phthalatedisruptsplacentalgrowthanddevelopmentin pregnantmice.JHazardMater,2015,297:25-33.12.Fen-FangHong,Fa-XianGuo,YingZhou,Qin-HuaMin,Da-LeiZhang,Bei Yang,Wei-YingZhou,LeiWu,Zhi-PingWei,HuiLiu,Shu-LongYang*.Shenfu injectionprotectshumanECV304cellsfromhydrogenperoxideviaits anti-apoptosisway.JournalofEthnopharmacology,2015,163(2):203-209.13.BeiYang,WeiyingZou,ZhenzhenHu,FangmingLiu,LingZhou,ShulongYang,HaibinKuang,TingZou,DaleiZhang * ,InvolvementofOxidativeStressand InflammationinLiverInjuryCausedbyPerfluorooctanoicAcidExposurein Mice,BioMedResearchInternational,2014,409837:1-7 14.ZhenyuCai,DaleiZhang,YingYing,MinYan,JianhuaYang,FangyunXu,KiwanOh，ZhenzhenHu * .InhibitorymodulationofCARTpeptidesinaccumbal neuronthroughdecreasinginteractionofCaMKIIαwithdopamineD3receptors.BrainResearch,2014,1557:101-110.(co-firstauthor) 15.DaleiZhang,BeiYang,WeiyingZou,,MingdiXiong,LeiWu,JingleiWang,,SifanXu,TingZou*,Estradiolsynthesisandreleaseinculturedfemaleratbone marrowstemcells.BioMedResearchInternational,2013,301540:1-6 16.LipingZheng,JiangHuang,DaleiZhang,LiangquangXu,FangLi,LeiWu,ZhengyuLiu,YuehuiZheng*.c-erbB(2)andc-mybInduceMouseOocyte MaturationInvolvingActivationofMaturationPromotingFactor.DNAandCell Biology,2012,31(2):164-170.(co-firstauthor) 17.ZhengLP,ZhangDL,HuangJ,XuLQ,XuAX,DuXY,TangDF,ZhengYH.Proto-oncogenec-erbB2initiatesratprimordialfolliclegrowthviaPKCand MAPKpathways.ReproductiveBiologyandEndocrinology.2010,8(66):1-16.(co-firstauthor) 18.ZhangDalei,WangKaiming,ZhangCaiqiao.Ginsenosidesstimulatedthe proliferationofmousespermatogoniainvolvingactivationofproteinkinaseC.J ZhejiangUnivSciB.2009,10(2):87-92.19.ZhangDa-lei,MiYu-Ling,WangKai-ming,ZengWei-dong,ZhangCai-qiao.Attenuatingeffectofdaidzeinonpolychlorinatedbiphenyls-inducedoxidative toxicityinmousetesticularcells.JZhejiangUnivSciB.2008,9(7):567-571.20.DaleiZhang,CaiqiaoZhang,JianxinLiu.Ginsenosidespromotemeiotic maturationofmouseoocytesincumulus-oocytecomplexesinvolvingincreased expressionofnitricoxidesynthase.NutritionResearch.2006,26(11):585-590.