阮征 - 南昌大学 - 食品学院

个人简介

阮征,教授，博士生导师，食品营养与安全系副主任。赣江特聘教授，食品国家重点实验室固定成员，江西省杰青获得者。世界中医药学会联合会中医与农业产分副会长，中国农学会微量元素与食物链分会理事，中国农学会农产品加工分会理事。讲授课程食品化学，功能食品学学术成就近五年来研究方向为食品分子营养和功能配料，集中在植物多酚活性成分调控营养代谢和增强肠道屏障，探索构建靶向肠道健康的精准营养技术与平台。研究成果包括:第一，在国内外率先系统揭示了植物多酚改善肠道损伤（膳食性、生理病理性和化学性三类模型）和增强肠道屏障的作用机制，揭示了植物多酚调控肠道上皮细胞差异枢纽蛋白、信号通路和紧密连接蛋白随时空序列的表达/组装/迁移/分布的动态变化规律，阐明了肠腔与黏液层两个空间中黏蛋白与黏蛋白降解菌的响应差异机制；第二，探明了植物多酚保护机体肝脏功能与细胞线粒体代谢的作用机制；第三，创新建立了功能性植物提取物配伍和畜禽健康养殖（肉质提升与抗生素替代）技术体系并产业化推广。相关研究成果从有别于经典营养学角度（即肠道屏障和菌群）进一步补充与认识植物多酚的营养代谢，对植物综合加工利用与多酚营养代谢评价的科技创新起到极大的推动作用。以第一或通讯作者在本领域优质期刊发表论文42篇并被广泛引用，中英文引用970多次；编写专著与教材2部，参编2部。研究成果转化或产业化多项，广泛应用于农业与食品业，产生直接和间接经济效益5亿多元，具有显著的经济和社会效益。承担课题 1，基于组学技术研究膳食绿原酸增强肠黏膜屏障的分子机制（项目批准号：31872897），2019-2022，国家自然科学基金面上项目； 2，新型POPs识别及在畜禽体内迁移转化及控制机理（2017YFC1600302），2018-2021，国家重点研发计划重点专项； 3，猪微量元素、维生素和电解质失衡防控技术研究（2016YFD0501201），2016-2020，国家重点研发计划重点专项； 4，基于组学技术研究膳食绿原酸增强肠黏膜屏障紧密连接的作用机制，2018-2020，江西省自然科学基金杰出青年项目； 5，葛薯主副食品加工与营养品制备关键技术（20071BBF60048），2017-2018，江西省重点研发计划项目；

研究领域

1，功能食品：研制改善胃肠功能健康与抑制腹部肥胖的功能食品； 2，分子营养：食物功能成分（氨基酸与酚酸）调控代谢及肠黏膜屏障的作用机制； 3，农产品与农业资源高效利用：农副产品高值化利用。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

32YanwenXue#,FangHuang#,RongxueTang,QingshengFan,BingZhang,ZhenjiangXu,XiaomingSun*,ZhengRuan*.Chlorogenicacidattenuatescadmium-inducedintestinalinjuryinSprague–Dawleyrats.FoodandChemicalToxicology.2019.133,110751,10.1016/j.fct.2019.110751. 31ZhenlongChen#,YuhuiYang#,ShumeiMi,QingshengFan,XiaomingSun,BaichuanDeng,GuoyaoWu,YafeiLi,⁎,QuanchengZhou*,ZhengRuan*.Hepatoprotectiveeffffectofchlorogenicacidagainstchronicliverinjuryininflammatoryrats.JournalofFunctionalFoods,2019.62:103540.https://doi.org/10.1016/j.jff.2019.103540. 30MengdieChen,YuyuLiu,ShanbaiXiong,MouchengWu,BinLi,ZhengRuan*,XiaoboHu*.DietaryL-tryptophanalleviatedLPS-inducedintestinalbarrierinjurybyregulatingtightjunctionsinaCaco-2cellmonolayermodel,Food&Function,DOI:10.1039/c9fo00123a2019-3-19 29YiWu,WenhuiLiu,QiLi,YafeiLi,YaliYan,FangHuang,XinWu,QuanchengZhou,XugangShu*,ZhengRuan*. Dietarychlorogenicacidregulatesgutmicrobiota,serum-freeaminoacidsandcolonicserotoninlevelsingrowingpigs.InternationalJournalofFoodSciencesandNutrition,2018,69(5):566-573,doi:10.1080/09637486.2017.1394449. https://www.ncbi.nlm.nih.gov/pubmed/29141471 28WenhuiLiu,ShumeiMi,ZhengRuan*,JingLi,XugangShu,KangYao,MinJiang,ZeyuanDeng.DietaryTryptophanEnhancedtheExpressionofTightJunctionProteinZO-1inIntestine.JournalofFoodScience,2017,82(2):562-567 27Zhou,Quancheng;Feng,Chuanxing;Ruan,Zheng*.Inhibitoryeffectofagenisteinderivativeonpigmentationofguineapigskin.RSCAdvances,2017,3(13):7914-7919 26ZhengRuan,ShumeiMi,LiliZhou,YanZhou,JingLi,WenhuiLiu,ZeyuanDeng*,YulongYin*.ChlorogenicacidenhancesintestinalbarrierbydecreasingMLCKexpressionandpromotingdynamicdistributionoftightjunctionproteinsincoliticrats.JournalofFunctionalFoods,2016,26:698-708. 25Y.Zhou,Z.Ruan*,X.L.Li,S.M.Mi,M.Jiang,W.H.Liu,X.Wu,G.L.Jiang,Y.L.Yin*.EucommiaulmoidesOliverleafpolyphenolsupplementationimprovesmeatqualityandregulatesmyofibertypeinfinishingpigs.JournalofAnimalScience,2016,94(S3):164-168 24,YanZhou,ZhengRuan*,LiliZhou,XugangShu,XiaohongSun,ShumeiMi,YuhuiYang,YulongYin*.Chlorogenicacidamelioratesendotoxin-inducedliverinjurybypromotingmitochondrialoxidativephosphorylation.BiochemicalandBiophysicalResearchCommunications,2016,469(4):1083-1089 23,X.L.Li,M.Jiang,Z.Ruan*,S.M.Mi,X.Wu,K.Yao,X.Xiong,Y.Zhou,Y.L.Yin.Tryptophanincreasesintestinalpermeabilityanddecreasesintestinaltightjunctionproteinexpressioninweanlingpiglets.JournalofAnimalScience,2016,94(S3):87-90. 22,YanZhou,LiliZhou,ZhengRuan*,ShumeiMi,MinJiang,XiaolanLi,XinWu,ZeyuanDeng,YulongYin.Chlorogenicacidamelioratesintestinalmitochondrialinjurybyincreasingantioxidanteffectsandactivityofrespiratorycomplexes.Bioscience,Biotechnology,andBiochemistry,2016,80(5):962-971. 21,YanZhou,ZhengRuan*,YanmeiWen,YuhuiYang,ShumeiMi,LiliZhou,XinWu,ShengDing,ZeyuanDeng,GuoyaoWu,YulongYin.Chlorogenicacidfromhoneysuckleimproveshepaticlipiddysregulationandmodulateshepaticfattyacidcompositioninratswithchronicendotoxininfusion.JournalofClinicalBiochemistryandNutrition.2016,58(2):146-155. 20,YanZhou,ZhengRuan*,LiliZhou,YuhuiYang,ShumeiMi,ZeyuanDeng,YulongYin.Chlorogenicaciddecreasedintestinalpermeabilityandamelioratedintestinalinjuryinratsviaameliorationofmitochondrialrespiratorychaindysfunction.FoodScienceandBiotechnology,2016,25(1):253-260. 19YanZhou,ZhengRuan*,XiaoliZhou,XiaoliuHuang,HuaLi,LingWang,CuiZhang,ZeyuanDeng,GuoyaoWu,YulongYin.LactosucroseattenuatesintestinalinflammationbypromotingTh2cytokineproductionandenhancingCD86expressionincoliticrats.Bioscience,Biotechnology,andBiochemistry.2015,79(4):643–651. 18YanZhou,ZhengRuan*,XiaoliZhou,XiaoliuHuang,HuaLi,LingWang,CuiZhang,ShiqiangLiu,ZeyuanDeng,GuoyaoWu,YulongYin.Dietwithlactosucrosesupplementationamelioratestrinitrobenzenesulfonicacid-inducedcolitisinrats.FoodFunction,2015,6,161-171. 17ZhengRuan,YuhuiYang,YanmeiWen,YanZhou,XiaofangFu,ShengDing,GangLiu,KangYao,XinWu,ZeyuanDeng,GuoyaoWu,YulongYin*.MetabolomicanalysisofaminoacidandfatmetabolisminratswithL-tryptophansupplementation.AminoAcids.2014,46:2681-2691. 16ZhengRuan,YuhuiYang,YanZhou,YanmeiWen,ShengDing,GangLiu,XinWu,PengLiao*,ZeyuanDeng,HousseinAssaad,GuoyaoWu,YulongYin*.Metabolomicanalysisofaminoacidandenergymetabolisminratssupplementedwithchronicchlorogenicacid.AminoAcids,2014,46:2219-2229.