陈坚 - 苏州大学 - 纳米科学技术学院

个人简介

学术经历： 2003年北京大学生命科学学院获得理学学士学位 2011年美国德克萨斯西南医学中心发育与遗传系获得博士学位 2011年美国德克萨斯西南医学中心发育与遗传系进行博士后研究 2011至2013年美国OriGene Technologies担任高级科学家，研发总监 2014年6月加入苏州大学功能纳米与软物质研究院，被聘为教授，博士生导师

研究领域

1. 使用小鼠模型研究肿瘤（胶质脑细胞瘤和胃肠道肿瘤）的发生，维系以及肿瘤治疗 2. 研究正常成年干细胞以及肿瘤干细胞“干性”的分子机理 3. 免疫检测以及肿瘤的免疫治疗 4. 使用纳米材料检测、示踪、靶向治疗肿瘤

近期论文

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1. Efrain Sanchez-Ortiz, Woosung Cho, Inga Nazarenko, Wei Mo, Jian Chen#, and Luis F. Parada# (2014) NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.Genes Dev.28 (21) (Cover article；#,corresponding author) 2. Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LF (2013). CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors. Cell. 152(5):1077-90 3. Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF (2012). A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 488(7412):522-6. (Selected by Faculty of 1000; the discovery was reported by BBC, NPR, China Daily and more than 150 other media globally; it was selected as one of the world’s top10 annual scientific breakthrough by Chinese Academic of Sciences http://news.sciencenet.cn/htmlnews/2013/1/274159.shtm) 4. Chen J, Mckay RM, Parada LF (2012). Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell. 30;149(1):36-47. 5. Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, Powell CM, Kernie SG (2011). Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. J Neurosci. 31(13):4906-16. 6. Alcantara Llaguno S*, Chen J*, Kwon CH*, Jackson EL, Li Y, Burns DK, Alvarez-Buylla A, Parada LF (2009). Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell. 15:45-56. (*, Authorship equally shared) (Selected by Faculty of 1000) 7. Chen J*, Kwon CH*, Lin L, Li Y, Parada LF (2009). Inducible site-specific recombination in neural stem/progenitor cells. Genesis. 47(2):122-31. (*, Authorship equally shared) 8. Alcantara Llaguno SR, Chen J, Parada LF (2009). Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications. Clin Cancer Res 1;15(23):7124-9. 9. Lin L, Chen J, Richardson, Parada LF (2009). Mice lacking neurofibromin develop gastric hyperplasia. Am J physiol Gastriointest Liver Physiol. 297: G751-G761 10. Llaguno SA, Chen J, Kwon CH, Parada LF (2008). Neural and Cancer Stem Cells in Tumor Suppressor Mouse Models of Malignant Astrocytoma. Cold Spring Harb Symp Quant Biol. 73:421-6. 11. Li Y, Luikart BW, Birnbaum S, Chen J, Kwon CH, Kernie SG, Bassel-Duby R, Parada LF (2008). TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron. 59:399-412. (Selected by Faculty of 1000) 12. Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF (2008). Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68:3286-94. 13. Lush ME, Li Y, Kwon CH, Chen J, Parada LF (2008). Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci. 28:1580-7. 14. Wang P*, Chen J*, Zheng A*, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M, Deng H (2004). Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun. 315:439-44. (*,Authorship equally shared) 15. Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G, Zhang H, Luo H, Zhu L, Jiang P, Chen L, Shen Y, Luo M, Zuo G, Hu J, Duan D, Nie Y, Shi X, Wang W, Han Y, Li T, Liu Y, Ding M, Deng H, Xu X (2004). Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol. 78:11334-9. 16. Nie Y, Wang P, Shi X, Wang G, Chen J, Zheng A, Wang W, Wang Z, Qu X, Luo M, Tan L, Song X, Yin X, Chen J, Ding M, Deng H (2004). Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression. Biochem Biophys Res Commun. 321:994-1000. 17. Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, Shi X, Wang W, Ling C, Yin X, Fan K, Lai L, Ding M, Deng H (2004). Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. Biochem Biophys Res Commun. 319:746-52.