娄新徽 - 首都师范大学

研究领域

1）生物传感器（Biosensors）：基于纳米材料和生物技术，用于复杂样品中目标分子检测的高效生物传感新机理和新方法的研究。探索这些新方法在重大疾病早期诊断、致病菌和病原体检测，环境毒素检测，食品污染物以及重要生理过程研究中的应用。 2）生物识别分子（核酸适配体）的快速高通量筛选技术（Rapid directed evolution）：探索从随机合成分子库中，筛选具有某种特定功能的分子的新技术。特别是探索筛选具有催化性能、抑制性能或者构相变化的核酸分子的新方法。研究所筛选出功能分子在疾病治疗、制药、疾病诊断、环境监测等重大领域的应用。

近期论文

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Wang, W.; Ding, X.; He, M.; Lou, X. H.* Kinetic Adsorption Profile and Conformation Evolution at the DNA-Gold Nanoparticle Interface Probed by Dynamic Light Scattering. Anal. Chem. 2014, 10.1021/ac502440h (IF 5.825） Wu, S.; Liang, P. P.; Yu, H. X.; Xu, X. W.; Liu, Y.; Lou, X. H.; Xiao, Y. Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles. Anal. Chem. 2014, 86, 3461-3467 (IF 5.825） Lou, X. H.* ;Zhao, T.; Liu, R.; Ma, J.; Xiao, Y.Self-Assembled DNA Monolayer Buffered Dynamic Ranges of Mercuric Electrochemical Sensor. Anal. Chem. 2013, 85，7574?7580. (IF 5.825） Lou, X. H.*; Zhang, Y. Mechanism Studies on NanoPCR and Applications of Gold Nanoparticles in Genetic Analysis. ACS Appl. Mater. Interfaces, 2013, 5 (13), 6276–6284（IF 5.008） Du, J.; Liu, M.Y.; Lou, X. H.*; et al. Highly Sensitive and Selective Chip-Based Fluorescent Sensor for Mercuric Ion: Development and Comparison of Turn-On and Turn-Off Systems. Anal. Chem. 2012, 84，8060-8066.（IF 5.825） Zou, R. X.; Lou, X. H. * Ou, H. C.; Zhang, Y.; Wang, W. J.; Yuan, M.; Guan, M.; Luo, Z. F.; Liu, Y. Y. Highly Specific Triple-Fragment Aptamer for Optical Detection of Cocaine. RSC Advances, 2012, 2 (11), 4636 - 4638. （IF 3.708）（热点文章，英国皇家化学会新创刊综合性期刊） Zheng, D.M.; Zou, R.X.; Lou, X. H. * Label-free Fluorescent Detection of Ions, Proteins and Small Molecules Using Structure-Switching Aptamers, SYBR Gold and Exonuclease Ⅰ. Anal. Chem. 2012, 84， 3554-3560.（IF 5.825） Yuan, M.; Lou, X. H.*; Chen, C.; Gang, W.; Lan M. B.; Zhao, J. L.; Zhu, Y. G.. Sensitive label-free oligonucleotide-based microfluidic detection of mercury (II) ion by using exonuclease I. Biosens. Bioelectron. 2012, 31,330-336. （IF 6.451） Liu, M. Y.; Lou, X. H.*; Juan, D.; Guan, M.; Wang, J.; Ding, X. F.; Zhao, J. L. DNAzyme-based fluorescent microarray for highly selective and sensitive detection of lead (II). Analyst, 2012, 137,70-72. （IF 3.906） Liu, M. Y.; Yuan, M.; Lou, X. H.*; Mao, H. J. ; Zheng, D. M.; Zou, R. X.; Zou, N. L.; Tang, X. R.; Zhao, J. L. Label-free optical detection of single-base mismatches by the combination of nuclease and gold nanoparticles. Biosens. Bioelectron. 2011, 26, 4294-4300. （IF 6.451） Oh, S.S.; Plakos, K.; Lou, X. H.; Xiao, Y.; Soh, H.. In Vitro Selection of Structure-Switching, Self-Reporting Aptamers. Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 14053-14058. （IF 9.809） Wang, X.; Lou, X. H.; Mao, H. J. QDs-DNA nanosensor for the detection of hepatitis B virus DNA and the single-base mutants. Biosens. Bioelectron.2010, 25, 1934-40. （IF 6.451） Liu M.; Jia C.; Huang Y.; Lou, X. H.; Jin, Q.; Zhao, J.; Yao, S.; Xiang J. Highly Sensitive Protein Detection Using Enzyme-labeled Gold Nanoparticle Probes. Analyst,2010, 135(2), 327-31. （IF 3.906） Liu M.; Jia C.; Jin, Q.; Lou, X. H.; Yao, S.; Xiang J. Zhao, J. Novel colorimetric enzyme immunoassay for the detection of carcinoembryonic antigen. Talanta,2010, 81, 1625-9. (IF 3.498) Lou, X. H.; Qian, J.; Xiao, Y.; Viel, L.; Gerdon, A. E.; Lagally, E. T.; Atzberger, P.; Tarasow, T. M.; Heeger, A. J.; Soh, H. T. Micromagnetic Selection of Aptamers in Microfluidic Channels. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 2989-2994. （IF 9.809）（被Nature热评） Xiao, Y.; Lou, X. H.; UZAWA, T.; Plakos, K.; Plaxco, K.; Soh, H. An Electrochemical Sensor for Single Nucleotide Polymorphism Detection in Serum Based on a Triple-Stem DNA Probe. J. Am. Chem. Soc. 2009, 131, 15311-15316. (IF 11.444) Lou, X. H.*; Xiao, Y.; Wang, Y.; Mao, H.; Zhao J. Label-Free Colorimetric Screening of Exonuclease and Endonuclease Activity Using Unmodified Gold Nanoparticles. ChemBioChem, 2009, 10, 1973-1977. (IF 3.74) Xiao, Y.; Plakos, K.J.I.; Lou, X. H.; Qian, J.; White, R.J.; Plaxco, K. W.; Soh, h. T. Fluorescence Detection of Single Nucleotide Polymorphism via a Single Self-Complementary, Triple-Stem DNA Probe. Angew. Chem. Int. Ed. 2009, 48，4354-4358. （热点文章和被另一国际知名期刊ChemBioChem热评。）(IF 11.336) Ferguson, B.S.; Buchsbaum, S.; Swensen, J.; Hsieh, W.; Lou, X. H.; Soh, H.T. Integrated Microfluidic Electrochemical DNA Sensor" Anal. Chem. 2009, 81, 6503-6508. （热点文章）(IF 5.825) Qian, J.; Lou, X. H.; Zhang, Y.; Xiao, Y.; Soh, H.T. Generation of Highly Specific Aptamers via Micromagnetic Selection. Anal. Chem. 2009, 81, 5490 – 5495. (IF 5.825) Jia, C.; Zhong, X.; Bao, H.; Liu, M.; Jing, F.; Lou, X. H.; Yao,S.; Xiang, J.; Jin, Q.; Zhao J. Nano-ELISA for highly sensitive protein. Biosens. Bioelectron.2009, 24, 2836-2841. （IF 6.451） Lou, X. H.; He, L. Surface Passivation Using Oligo(Ethylene Glycol) in ATRP-Assisted DNA Detection. Sens. Actuator B2008, 129, 225-230. (IF 3.535) Lou, X. H.; Wang, C.; He, L. Core-shell Au Nanoparticle Formation with DNA-Polymer Hybrid Coatings Using Aqueous ATRP. Biomacromolecules, 2007, 8, 1385-1390. (IF 5.371) Lou, X. H.; Okelo, G.; He, P.; He, L. Polymers in Bioapplications --Drug Delivery and Biosensing. Anal. Bioanal. Chem.2006, 384, 525-531. (IF 3.659) Lou, X. H.; He, L. DNA-Accelerated Atom Transfer Radical Polymerization (ATRP) on Surface. Langmuir. 2006, 22, 2640-2646. (IF 4.187) Lou, X. H.; Lewis, M. S.; Gorman, C. B., He, L. Detection of DNA Point Mutation by Atom Transfer Radical Polymerization (ATRP).Anal. Chem.2005, 77, 4698 – 4705. (IF 5.825) Finkel, N. H; Lou, X. H.; Wang, C.; He, L. Barcoding the Microworld. Anal. Chem.2004, 76, 352A-359A. (IF 5.825)