曹胜利 - 首都师范大学

研究领域

1. 药物化学：以叶酸依赖性酶、蛋白激酶为作用靶点，设计合成结构新颖的杂环化合物及其衍生物，测定对人肿瘤细胞增殖的抑制作用，筛选和发现抗肿瘤活性先导化合物。进而在3D-QSAR研究结果指导下，进行活性化合物的结构修饰与优化，并探讨其作用机制。 2. 有机合成：药物及中间体的合成工艺研究；杂环化合物的合成方法学研究；天然产物及类似物的合成等。

近期论文

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Cao, S. L.*; Han, Y.; Yuan, C. Z.; Wang, Y.; Xiahou, Z. K.; Liao, J.; Gao, R. T.; Mao, B. B.; Zhao, B. L.; Li, Z. F.; Xu, X.*Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline. Eur. J. Med. Chem. 2013, 64, 401-409. Lin, H. H.; Wu, W. Y.; Cao, S. L.*; Liao, J.; Ma, L.; Gao, M.; Li, Z. F.; Xu, X.* Synthesis and antiproliferative evaluation of piperazine-1-carbothiohydrazide derivatives of indolin-2-one. Bioorg. Med. Chem. Lett. 2013, 23, 3304-3307. Wu, W. Y.; Cao, S. L.*; Mao, B. B.; Liao, J.; Li, Z. F.; Song, H. B.; Xu, X.* Synthesis and antiproliferative evaluation of hybrids of indolin-2-one and quinazoline-4(3H)-one linked via imine bond. Lett. Drug Des. Discov. 2013, 10, 61-66. Cao, S. L.*; Xu, H.; Wang, Y.; Liao, J.; Zhang, J. J.; Li, Z. F.; Guo, Y. W.; Li, X. R.; Cui, X. M.; Xu, X.* Synthesis and cytotoxic evaluation of quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or N-methyldithiocarbamate side chains. Med. Chem. 2012, 8, 163-173. Wang, Y.; Zhang, M.; Cao, S. L.*; Lin, H. H; Gao, M.; Li, Z. F. Synthesis of 1-substituted 4(1H)-quinazolinones under solvent-free condition. Synth. Commun. 2012, 42, 2715-2727. Wu, G. L.; Cao, S. L.*; Chen, J.*; Chen, Z*. Synthesis of pyrimidine modified NHC ruthenium-alkylidene catalysts and its application in RCM, CM, EM and ROMP reactions. Eur. J. Org. Chem. 2012, (34), 6777-6784. Cao, S. L.*; Wang, Y.; Zhu, L.; Liao, J.; Guo, Y. W.; Chen, L. L.; Liu, H. Q.; Xu, X. Synthesis and cytotoxic activity of N-((2-methyl-4(3H)-quinazolinon-6-yl)methyl)dithiocarbamates. Eur. J. Med. Chem. 2010,45, 3850-3857. Cao, S. L.*; Guo, Y. W.; Wang, X. B.; Zhang, M.; Feng, Y. P.; Jiang, Y. Y.; Wang, Y.; Gao, Q.; Ren, J. Synthesis and cytotoxicity screening of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones. Arch. Pharm. 2009, 342, 182-189. Cao, S. L.*; Zhang, M.; Feng, Y. P.; Jiang, Y. Y.; Zhang, N. Synthesis of 3-aryl-4(3H)-quinazolinones from anthranilic acids and triethyl orthoformate. Synth. Commun. 2008, 38, 2227-2236. Cao, S. L.*; Feng, Y. P.; Zheng, X. L.; Jiang, Y. Y.; Zhang, M.; Wang, Y.; Xu, M. Synthesis of substituted-benzylamino- and heterocyclylmethylamino-carbodithioate derivatives of 4(3H)-quinazolinone and theircytotoxic activity. Arch. Pharm.2006, 339,250-254. Cao, S. L.*, Feng, Y. P., Jiang, Y. Y., Liu, S. Y., Ding, G. Y., Li, R. T., Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains. Bioorg. Med. Chem. Lett. 2005, 15, 1915-1917. Cao, S. L.*, Wan, R., Feng, Y. P., New synthesis of thymidylate synthase inhibitor Raltitrexed. Synth. Commun. 2003, 33(20), 3519-3526.