周文 - 上海交通大学

研究领域

1，活性小分子化合物的设计与全合成。 2，酶化学合成天然多糖及其抗肿瘤功能与机制研究。

近期论文

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Wen Zhou, Pohuang Hsieh, Yongmei Xu, Timothy R. O’Leary, Xuefei Huang, Jian Liu. Design and Synthesis of Active Heparan Sulfate-based Probes, ChemComm., 2015, Dol:10.1039/C5cc02008E. Jiahua Cui, Qingqing Meng, Xu Zhang, Qing Cui, Wen Zhou, Shaoshun Li. Design and synthesis of new naphthoflavones as Cyp1B1 inhibitors to overcome docetaxel-resistance associated with CY1P1B1 over-expression, J. Med. Chem. 2015, 58(8): 3534-3547 (共同通讯作者) Liu J, Zhou W, Li SS, Sun Z, Lin BZ, Lang YY, He JY, Cao XH, Yan TD, Wang L, Lu JM, Han YH, Cao Y, Zhang XK, Zeng JZ. Modulation of orphan nuclear receptor nur77-mediated apoptotic pathway by acetylshikonin and analogues. Cancer Res. 2008, 68(21), 8871-8880. (共同第一作者) Wang R.B., Zhou W, Meng Q.Q., Zhang X , Ding J , Yan Xu, Song HL, Kai Yang , Li S.S. Design, synthesis and biological evaluation of novel shikonin and alkannin derivatives as potent antitumor agents via a prodrug approach. ChemMedChem, 2014, 9, 2798-2808. (共同第一和通讯作者) Zhou W, Zhang X, Xiao L, Ding J, Liu QH, Li SS. Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives, Eur. J. Med. Chem. 2011,46, 3168- 3189. Zhou W, Peng Y, Li SS. Semi-synthesis and antitumor activity of 5, 8-O- dimethylacyl- shikonin derivatives. Eur. J. Med. Chem. 2010, 45, 6005-6011. Zhou W, Jiang HD, Peng Y, Li SS. Comparative study on enantiomeric excess of main Akannin/Shikonin derivatives isolated from the roots of three endemic Boraginaceae plants in China. Biomed. Chromatogr. 2011, 10, 1067-1075. Peng J Q , Zhou W , Xia XY, Qi X, Sun L, Wang M, Wu ZH, and Li Z R Encapsulation of Acetylshikonin by Polyamidoamine dendrimers for preparing prominent nanoparticles, AAPS PharmSciTech, 2014, 15(2):425-33 (共同第一作者) Zhang X, Wang R.B, Zhou W, Xiao S., Meng Q.Q. and Li S.S. Antitumor Activity of DMAKO-05, a Novel Shikonin Derivative, and Its Metabolism in Rat Liver Microsome, AAPS PharmSciTech, 2015,16(2):259-266. (共同通讯作者) Zhou W, Xu DF, Zhao AH, Li SS. A mild and efficient semi-synthesis of shikoninleuco- acetates. J. Indian Chem. Soc. 2008, 85(1), 75-77. Wang R, Yin R, Zhou W, Xu D, Li SS. Shikonin and its derivatives: a patent review. Exper Opin Ther Pat, 2012, 22 (9): 977-997. Rao Z, Liu X, Zhou W, Yi J, Li SS. Synthesis and antitumour activity of β- hydroxy- isovalerylshikonin analogues, Eur J Med Chem, 2011, 46: 3934-3941.