王志龙 - 上海交通大学

研究领域

1.生物技术药物：生物催化是合成复杂结构药物或前体的重要手段。应用浊点系统技术解除生物催化（微生物转化与发酵）过程中存在的底物生物利用度低、底物/产物抑制、产物进一步降解等瓶颈问题。 2. 微生物次级代谢：微生物次级代谢受到多种环境因素的调控。应用浊点系统萃取发酵技术改变营养物质的吸收和次级代谢产物的分泌，进而调控微生物次级代谢的途径及效率。

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Zhiqiang Hu, Xuehong Zhang, Zhenqiang Wu*, Hanshi Qi, Zhilong Wang*. Perstraction of intracellular pigments by submerged cultivation of Monascus in nonionic surfactant micelle aqueous solution. Applied microbiology and biotechnology. 2012, 94: 81-89 Zhiqiang Hu, Xuehong Zhang, Zhenqiang Wu, Hanshi Qi, Zhilong Wang*. Export of intracellular Monascus pigments by two-stage microbial fermentation in nonionic surfactant micelle aqueous solution. Journal of biotechnology. 2012, 162: 202-209 Biyu Kang, Xuehong Zhang, Zhenqiang Wu, Hanshi Qi, Zhilong Wang*. Solubilization capacity of nonionic surfactant micelles strong influence on export of intracellular pigments in Monascus fermentation. Microbial biotechnology. 2013, 6(5): 540-550 Biyu Kang, Xuehong Zhang, Zhenqiang Wu, Hanshi Qi, Zhilong Wang*. Effect of pH and nonionic surfactant on profile of intracellular and extracellular Monascus pigments. Process biochemistry, 2013, 48: 759-767 Biyu Kang, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang*, Sunghoon Park. Production of citrinin-free Monascus pigments by submerged culture at low pH. Enzyme and microbial technology, 2014, 55: 50-57 Lingjie Shen, Xuehong Zhang, Mingzhu Liu, Zhilong Wang*. Microemulsion extraction of Monascus pigments from nonionic surfactant using high polarity of diethyl ether as excess oil phase. Separation science and technology, 2014, 49: 2346-2351 Lingjie Shen, Xuehong Zhang, Mingzhu Liu, Zhilong Wang*. Transferring of red Monascus pigments from nonionic surfactant to hydrophobic ionic liquid by novel microemulsion extraction. Separation and purification technology, 2014, 138: 34-40 Xu Xiong, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang*. Optimal selection of agricultural products to inhibit citrinin production during submerged culture of Monascus anka. Biotechnology and bioprocess engineering, 2014, 19:1005-1013 Xu Xiong, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang*. Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution. Applied microbiology and biotechnology, 2015, 99 (3):1173-1180 Xu Xiong, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang*. Coupled aminophilic reaction and directed metabolic channeling to red Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution. Process biochemistry, 2015, 50(2): 180-187 Sijia Zhong, Xuehong Zhang*, Zhilong Wang*. Preparation and characterization of yellow Monascus pigments. Separation and purification technology, 2015, 150:139-144