当前位置: X-MOL首页全球导师 国内导师 › 孟青青

研究领域

抗肿瘤药物的设计及合成;分子影像探针的设计合成及活体成像研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Cui, J.; Meng, Q.(共同第一作者); Zhang, X.; Cui, Q.; Zhou, W.; Li, S. “Design and Synthesis of New α-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression.” J. Med. Chem., 2015, 58, 3534-3547. Meng,Q.; Liu, Z.; Li, F.; Ma, J.; Wang, H.; Huan, Y.; Li Z.* “An HDAC-Targeted Imaging Probe LBH589?Cy5.5 for Tumor Detection and Therapy Evaluation.” Mol. Pharmaceutics, 2015, 12, 2469-2476. Wang, R.; Zhou, W.*; Meng, Q.; Zhang, X.; Ding, J.; Xu, Y.; Song, H.; Yang, K.; Cui,J.; Li, S*. “Design, Synthesis, and Biological Evaluation of Shikonin and Alkannin Derivatives as Potential Anticancer Agents via a Prodrug Approach.” ChemMedChem, 2014, 9, 2798-2808. Wu,P.; Zhang, J.; Meng Q.; Nare, B.; Jacobs ,R.; Zhou, H*. “Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei.” Eur. J. Med. Chem., 2014, 81, 59-75. Zhao, Y; Meng, Q; Bai, L; Zhou, H*. “In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors.” Int. J. Mol. Sci. 2014, 15, 1358-1373. Meng, Q.; Li, F.; Jiang,S.; Li, Z*. “Novel 64Cu-Labeled CUDC-101 for in Vivo PET Imaging of Histone Deacetylases.” ACS Med. Chem. Lett., 2013, 4, 858-862. Meng, Q.; Li, Z*. “Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer.” Int. J. Biomedical Imaging, 2013, 2013, 230487. Zhao, Y.; Wang Q.; Meng, Q.; Ding D.; Yang H.; Gao, G.; Li, D.; Zhu, W.; Zhou, H*. “ Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis.” Bioorg. Med. Chem. 2012, 20, 1240-1250. Ding, D.; Meng, Q. (共同第一作者); Gao, G.; Zhao,Y.; Wang, Q.; Nare, B.; Jacobs, R.; Rock, F.; Alley, M. R. K.; Plattner, J. J.; Chen, G.; Li, D.; Zhou, H*. “Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal Agents.” J. Med. Chem. 2011, 54, 1276-1287. Wu, M.; Meng, Q.; Ge, M.; Bai, L.; Zhou, H*. “2,3,6-Trideoxy sugar nucleotides: synthesis and stability.” Tetrahedron Lett. 2011, 52, 5799-5801. Qiao, Z.; Wang, W.; Wang, L.; Wen, D.; Zhao, Y.; Wang, Q.; Meng, Q.; Chen, G.; Wu, Y.; Zhou, H*. “Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.” Bioorg. Med. Chem. Lett. 2011, 21, 6389-6392. Wu, P.; Meng, Q.; Zhou, H*. “Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel–Crafts reaction catalyzed by anhydrous stannic chloride.” Chin. Chem. Lett. 2011, 22, 1411-1414. (IF: 1.18) Ding, D.; Zhao, Y.; Meng, Q.; Xie, D.; Nare, B.; Chen, D.; Bacchi, C. J.; Yarlett, N.; Zhang, Y. K.; Hernandez, V.; Xia, Y.; Freund, Y.; Abdulla, M.; Ang, K. H.; Ratnam, J.; McKerrow, J. H.; Jacobs, R. T.; Zhou, H.; Plattner, J. J. “Discovery of novel benzoxaborole-based potent antitrypanosomal agents.” ACS Med. Chem. Lett. 2010, 1, 165-169. Ye, L.; Ding, D.; Feng, Y.; Xie, D.; Wu, P.; Guo, H.; Meng, Q.; Zhou, H. “Convenient and versatile synthesis of formyl-substituted benzoxaboroles.” Tetrahedron 2009, 65, 8738-8744. 12 Chen, W.; Huang, T.; He, X.; Meng, Q.; You, D.; Bai, L.; Li, J.; Wu, M.; Li, R.; Xie, Z.; Zhou, H.; Zhou, X.; Tan, H.; Deng, Z. “Charaterization of the polyoxin biosynthesis gene cluster from Streptomyces cacaoi and engineered production of polyoxin H.” J. Biol. Chem. 2009, 284, 10627-10638. 32 Zhou, Y.; Meng, Q.; You, D.; Li, J.; Chen, S.; Ding, D.; Zhou, X.; Zhou, H.; Bai, L.; Deng, Z. “Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in streptomyces sp. strain FR-008.” Appl. Environ. Microbiol. 2008, 74, 7235-7242.15 Meng, Q.; Bai, H.; Li, F.; Wang, Q.; Tao, F. “A convenient synthesis of 2-aryl substituted benzo[f] [1,2,4]triazolo[1,5-a]azepine derivatives.” Chin. Chem. Lett., 2007, 18, 785-787. Meng, Q.; Bai, H.; Wang, Q.; Tao, F. “A general synthesis of furo[3,2-c][1,2,4]triazolo [1,5-a]azepine and furo [2,3-f][1,2,4]triazolo[1,5-a]azepine derivatives.” Synthesis, 2007, 33-38. Meng, Q.; Bai, H.; Li, Z.; Wang, Q.; Tao, F. “A facile approach to 4,5-dihydro[1,2,4] triazolo[3,2-d] [1,5]benzoxazepines.” Synthesis, 2007, 1629-1634.

推荐链接
down
wechat
bug