个人简介

Education: PhD - California Institute of Technology B.A. - Williams College

研究领域

Synthesis/Inorganic/Organic

Inspired by small molecule natural products, the Roizen laboratories will initiate research to access improved antibiotics, and selective ion channel inhibitors, with implications for the study and treatment of cancer, heart disease, and neurological disorders. This program will begin with the development of novel reaction methods, and where appropriate these methodologies will be advanced through mechanistic investigations. New reactions will be designed to streamline access to challenging natural products, such as the guaianolide sesquiterpenes. Access to these small molecules will enable us to collaborate with colleagues to probe the biological activity of these molecular architectures.

近期论文

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Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation. Yiyang Liu, Marc Liniger, Ryan M. McFadden, Jenny L. Roizen, Jacquie Malette, Corey M. Reeves, Douglas C. Behenna, Masaki Seto, Jimin Kim, Justin T. Mohr, Scott C. Virgil, Brian M. Stoltz. Beilstein J. Org. Chem., 2014, 10, 2501-2512. Speciation and decomposition pathways of ruthenium catalysts used for selective CH hydroxylation. Cornelia Flender, Ashley M. Adams, Jennifer L. Roizen, E. McNeill, J. Du Bois, Richard N. Zare. Chem. Sci., 2014, 5, 3309-3314. Analyzing Site-Selectivity in Rhodium espinoate-Catalyzed Intermolecular C-H Amination Reactions. Elizabeth N. Bess, Ryan J. DeLuca, Daniel J. Tindall, Martins S. Oderinde, Jennifer L. Roizen, Justin Du Bois, Matthew S. Sigman. J. Am. Chem. Soc., 2014, 136, 5783-5789. Selective Intermolecular Amination of C-H Bonds at Tertiary Carbon Centers. Jennifer L. Roizen, David N. Zalatan, Justin Du Bois. Angew. Chem. Int. Ed., 2013, 52, 11343-11346. Capturing fleeting intermediates in a catalytic C-H amination reaction cycle. Richard H. Perry, Thomas J. Cahill, III, Jennifer L. Roizen, Justin Du Bois, Richard N. Zare. Proc. Nat. Acad. Sci., 2012, 109, 18295-18299. Reagent-Controlled Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C-H Bonds. Jennifer L. Roizen, Mark E. Harvey, Justin Du Bois. Acc. Chem. Res., 2012, 45, 911-922. Direct and Efficient Enantioselective Synthesis of a cis-1,3-cyclopentendiol Building Block. Robert A. Craig, II, Jennifer L. Roizen, Russell C. Smith, Amanda C. Jones, Brian M. Stoltz. Org. Lett., 2012, 14, 5716-5719. Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope and Mechanistic Studies. Douglas C. Behenna, Justin T. Mohr, Nathaniel H. Sherden, Smaranda C. Marinescu, Andrew M. Harned, Kousuke Tani, Masaki Seto, Sandy Ma, Zolt??n Nov??k, Michael R. Krout, Ryan M. McFadden, Jennifer L. Roizen, John A. Enquist, Jr., David E. White, Samantha R. Levine, Krastina V. Petrovna, Akihiko Iwashita, Scott C. Virgil, Brian M. Stoltz. Chem. Eur. J. , 2011, 17, 14199-14223. Catalytic Enantioselective Alkylation of Substituted Dioxanone Enol Ethers. Rea