个人简介

Education: PhD - The Scripps Research Institute MS - Seoul National University BS - Seoul National University

研究领域

Synthesis/Biological/Organic

Research in the Hong group focuses on using chemical tools, in particular small molecules, to understand the signaling pathways in biology. We synthesize biologically interesting natural products and screen small molecule libraries to identify modulators of biological processes. Then, we explore their modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. In addition, we design and develop unique and efficient synthetic strategies that will allow rapid access to molecular complexity and structural diversity. Through multidisciplinary approaches, including organic synthesis, molecular biology, and cell biology, the cellular components and molecular events that embody cancer, immune response, and GPCR signaling have systematically been explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases. Synthesis of Natural Products and Study of Mode of Action: We synthesize biologically interesting natural products and explore the modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. Completed target molecules include largazole (a marine natural product with HDAC inhibitory activity), brasilibactin A (a cytotoxic siderophore), manassantins A and B (natural products with anti-HIF-1 activity), and subglutinols A and B (natural products with immunosuppressive activity). Development of Novel Synthetic Methodology: We design and develop unique and efficient synthetic strategies which will allow rapid access to molecular complexity and structural diversity. A specific area of interest includes the development of novel methods for the stereoselective synthesis of substituted tetrahydrofurans and tetrahydropyrans. Screen of Small Molecule Libraries for Identification of Small Molecule Modulators of Biological Processes: With the advent of combinatorial chemistry and other synthetic technologies, it is feasible to prepare large collections of synthetic organic molecules. These libraries are useful in providing molecules that can be used to probe relevant biological pathways. We are interested in identification of modulators of biological processes, including drug abuse and neurodegenerative diseases. Through multidisciplinary approaches, the cellular components and molecular events that embody cancer, immune response, and neurodegenerative diseases are systematically explored. Compounds employed in these studies could also advance the development of novel therapeutics for the treatment of human diseases.

近期论文

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Chung, B. C.; Zhao, J.; Gillespie, R. A.; Kwon, D. Y.; Guan, Z.; Hong, J.; Zhou, P.; Lee, S. Y. Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis. Science 2013, 341, 1012-1016. Strickland, E. C.; Geer, M. A.; Hong, J.; Fitzgerald, M. C. False Positive Rate of Protein Target Discovery using a Covalent Modification- and Mass Spectrometry-Based Proteomics Platform. J. Am. Soc. Mass Spectrom. in press. Law, M. E.; Corsino, P. E.; Jahn, S. C.; Davis, B. J.; Chen, S.; Patel, B.; Pham, K.; Lu, J.; Sheppard, B.; Norgaard, P.; Hong, J.; Higgins, P.; Kim, J.-S.; Luesch, H.; Law, B. K. Glucocorticoids and Histone Deacetylase Inhibitors Cooperate to Block the Invasiveness of Basal-like Breast Cancer Cells through Novel Mechanisms. Oncogene 2013, 32, 1316-1329. Kaoud, T. S.; Park, H.; Mitra, S.; Yan, C.; Tseng, C.-C.; Shi, Y.; Jose, J.; Taliaferro, J. M.; Lee, K.; Ren, P.; Hong, J.; Dalby, K. Manipulating JNK Signaling with ()-Zuonin A. ACS Chem. Biol. 2012, 7, 1873-1883. Kaoud, T.; Yan, C.; Mitra, S.; Tseng, C.-C.; Jose, J.; Taliaferro, J.; Tuohetahuntila, M.; Devkota, A.; Sammons, R.; Park, J.; Park, H.; Shi, Y.; Hong, J.; Ren, P.; Dalby, K. From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules. ACS Med. Chem. Lett. 2012, 3, 721-725. Lee, K.; Kim, H.; Hong, J. N-Heterocyclic Carbene-Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide. Angew. Chem., Int. Ed. 2012, 51, 5735-5738. Hong, J.; Luesch, H. Largazole: From Discovery to Broad-Spectrum Therapy. Nat. Prod. Rep. 2012, 29, 449-456. Lee, K.; Kim, H.; Hong, J. Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Michael Reactions: Synthesis of the Tetrahydropyran Cores of ent-(+)-Sorangicin A. Eur. J. Org. Chem. 2012, 1025-1032. Lee, W.-G.; Kim, W.-S.; Park, S.-G.; Kim, H.; Hong, J.; Ko, H.; Kim, Y.-C. Immunosuppressive Effects of Subglutinol Derivatives. ChemMedChem 2012, 7, 218-222. Byeon, S. R.; Park. H.; Kim, H.; Hong, J. Stereoselective Synthesis of 2,6-trans-Tetrahydropyran via Primary Diamine-Catalyzed Oxa-Conjugate Addition Reaction of alpha,beta-Unsaturated Ketone: Total Synthesis of Psymberin. Org. Lett. 2011, 13, 5816-5819. Park, H.; Kim, H.; Hong, J. A Formal Synthesis of SCH 351448. Org. Lett. 2011, 3742-3745. Lee, K.; Kim, H.; Hong, J. A Stereoselective Formal Synthesis of Leucascandrolide A. Org. Lett. 2011, 13, 2722-2725. Hong, J. Role of Natural Product Diversity in Chemical Biology. Curr. Opin. Chem. Biol. 2011, 15, 350-354. Kim, H.; Byeon, S. R.; Leed, M. G. D.; Hong, J. Intramolecular Michael Reactions of Aliphatic Aldehyde Enolates Generated by Imidazolium Carbenes. Tetrahedron Lett. 2011, 52, 2468-2470. Harrington, J. M.; Park, H.; Ying, Y.; Hong, J.; Crumbliss, A. L. Characterization of Iron(III) Sequestration by an Analog of the Cytotoxic Siderophore Brasilibactin A: Implications for the Iron Transport Mechanism in Mycobacteria. Metallomics 2011, 3, 464-471. Ying, Y.; Kim, H.; Hong, J. Stereoselective Synthesis of 2,6-cis- and 2,6-trans-Piperidines through Organocatalytic Aza-Michael Reactions: A Facile Synthesis of (+)-Myrtine and (-)-Epimyrtine. Org. Lett. 2011, 13, 796-799. Lee, S.-U.; Kwak, H. B.; Pi, S.-H.; You, H.-K.; Byeon, S.; Ying, Y.; Luesch, H.; Hong, J.*; Kim, S. H.* In Vitro and In Vivo Osteogenic Activity of Largazole, ACS Med. Chem. Lett. 2011, 2, 248-251. (*co-corresponding author) Liu, Y.; Salvador, L. A.; Byeon, S.; Ying, Y.; Kwan, J. C.; Law, B. K.; Hong, J.; Luesch, H. Anti-Colon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deaceylase Inhibitor. J. Pharmacol. Exp. Ther. 2010, 335, 351-361. Kim, H.; Hong, J. Total Synthesis of Cyanolide A and Confirmation of Its Absolute Stereochemistry. Org. Lett. 2010, 12, 2880-2883. Kim, H.; Baker, J. B.; Park, Y.; Park, H.-B.; DeArmond, P. D.; Kim, S. H.; Fitzgerald, M. C.; Lee, D.-S.; Hong, J. Total Synthesis, Assignment of the Absolute Stereochemistry, and Structure-Activity Relationship Studies of Subglutinols