个人简介

Education: Ph.D. - Massachusetts Institute of Technology B.A., magna cum laude - Wellesley College

研究领域

Biomolecular Structure and Function/Inorganic

Research in the Franz group is involved in elucidating the structural and functional consequences of metal ion coordination in biological systems. We are particularly interested in understanding the coordination chemistry utilized by biology to manage essential yet toxic species like copper and iron. Understanding these principles further guides our development of new chemical tools to manipulate biological metal ion location, speciation, and reactivity for potential therapeutic benefit. We use a combination of synthesis, spectroscopy, and biochemistry in our work. Please visit our group website to learn more about our research.

近期论文

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Copper Signaling Axis as a Target for Prostate Cancer Therapeutics Safi, R.; Nelson, E. R.; Chitneni, S. K.; Franz, K. J.; George, D. J.; Zalutsky, M. R.; McDonnell, D. P. Cancer Research 2014 Detection of Metal Ions, Anions, Small Molecules and Biomolecules using Metal ComplexesInorganic Chemical Biology: Principles, Techniques and Applications Franz, K. J.; Wang, Q. 2014 The Copper-Signaling Axis as a Target for Prostate Cancer Therapeutics Safi, R.; Nelson, E.R.; Chitneni, S.K.; Franz, K.J.; Thiele, D.J.; George, D.J.; Zalutsky, M.R.; McDonnell, D.P. Cancer Research 2013 Characterization of a photoswitching chelator with light-modulated geometric, electronic and metal-binding properties Franks, A.; Peng, D.; Yang, W.; Franz, K. J. Inorg. Chem 2013 Light uncages a copper complex to induce nonapoptotic cell death Kumbhar, Anupa A. and Franks, Andrew T. and Butcher, Raymond J. and Franz, Katherine J. Chemical Communications 2013 Clawing back: broadening the notion of metal chelators in medicine Franz, Katherine J. Current Opinion in Chemical Biology 2013 Application of inorganic chemistry for non-cancer therapeutics Franz, Katherine J. Dalton Transactions 2012 Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation Kielar, F. and Helsel, M. E. and Wang, Q. and Franz, K. J. Metallomics 2012 A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding Kielar, F.; Wang, Q.; Boyle, P. D. and Franz, K. J. Inorganica Chimica Acta 2012 Monitoring Beta-Secretase Activity in Living Cells with a Membrane-Anchored FRET Probe Folk, Drew S. and Torosian, Justin C. and Hwang, Sunhee and McCafferty, Dewey G. and Franz, Katherine J. Angewandte Chemie International Edition 2012