个人简介
Education:
PhD - University of Wisconsin
BS with Honors - Davidson College
研究领域
Biomolecular Structure and Function/Biological/Analytical
Dr. Fitzgerald??s research group is focused on studies of protein folding and function. The group utilizes a combination of covalent labeling strategies (e.g. protein amide H/D exchange and methionine oxidiation) and mass spectrometry techniques to investigate the thermodynamic properties of protein folding and ligand binding reactions. Current research efforts involve: (1) the development new biophysical methods that enable protein folding and stability measurements to be performed on the proteomic scale; and (2) the application of these new methods in the areas of disease detection, diagnosis, and therapy.
近期论文
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Energetics-Based Methods for Protein Folding and Stability Measurements
Geer, M.A. and Fitzgerald, M.C Annual Review of Analytical Chemistry 2013
Proteome-Wide Assay for Thermodynamic Analysis of Protein-Ligand Binding Interactions
Tran, D.T., Adhikari J., and Fitzgerald, M.C. Molecular and Cellular Proteomics 2013
Thermodynamic Analysis of Protein-Ligand Binding Interactions in Complex Biological Mixtures Using the Stability of Proteins from Rates of Oxidation
Strickland, E.C., Geer, M.A., Tran, D.T., Adhikari, J., West, G.M., DeArmond, P.D., Xu, Y., and Fitzgerald, M.C. Nature Protocols 2013
False-Positive Rate Determination of Protein Target Discovery using a Covalent Modification- and Mass
Strickland, E.C., Geer, M.A., Hong, J., and Fitzgerald, M.C. Journal of the American Society for Mass Spectrometry 2013
Evidence of Fe3+ Interaction with the Plug Domain of the Outer Membrane Transferrin Receptor Protein of Neisseria gonorrhoeae; Implications for Fe Transport
Banerjee, S., Parker-Siburt, C.J., Mistry, s., Nato, J.M., DeArmond, P.D., Fitzgerald, M.C., Lambert, L.A., Cronelissen, C.N., and Crumbliss, A.L. Metallomics 2012
Order out of Disorder ?C Working Cycle of an Intrinsically Unfolded Chaperone
Reichmann, D., Xu, Y Cremers, C.M., Ilbert, M., Mitelman, R., Fitzgerald, M.C., and Jakob, U. Cell 2012
Slow Histidine H/D Exchange Protocol for Thermodynamic Analysis of Protein Folding and Stability using Mass Spectr