个人简介

Education: PhD - University of Wisconsin BS with Honors - Davidson College

研究领域

Biomolecular Structure and Function/Biological/Analytical

Dr. Fitzgerald??s research group is focused on studies of protein folding and function. The group utilizes a combination of covalent labeling strategies (e.g. protein amide H/D exchange and methionine oxidiation) and mass spectrometry techniques to investigate the thermodynamic properties of protein folding and ligand binding reactions. Current research efforts involve: (1) the development new biophysical methods that enable protein folding and stability measurements to be performed on the proteomic scale; and (2) the application of these new methods in the areas of disease detection, diagnosis, and therapy.

近期论文

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Energetics-Based Methods for Protein Folding and Stability Measurements Geer, M.A. and Fitzgerald, M.C Annual Review of Analytical Chemistry 2013 Proteome-Wide Assay for Thermodynamic Analysis of Protein-Ligand Binding Interactions Tran, D.T., Adhikari J., and Fitzgerald, M.C. Molecular and Cellular Proteomics 2013 Thermodynamic Analysis of Protein-Ligand Binding Interactions in Complex Biological Mixtures Using the Stability of Proteins from Rates of Oxidation Strickland, E.C., Geer, M.A., Tran, D.T., Adhikari, J., West, G.M., DeArmond, P.D., Xu, Y., and Fitzgerald, M.C. Nature Protocols 2013 False-Positive Rate Determination of Protein Target Discovery using a Covalent Modification- and Mass Strickland, E.C., Geer, M.A., Hong, J., and Fitzgerald, M.C. Journal of the American Society for Mass Spectrometry 2013 Evidence of Fe3+ Interaction with the Plug Domain of the Outer Membrane Transferrin Receptor Protein of Neisseria gonorrhoeae; Implications for Fe Transport Banerjee, S., Parker-Siburt, C.J., Mistry, s., Nato, J.M., DeArmond, P.D., Fitzgerald, M.C., Lambert, L.A., Cronelissen, C.N., and Crumbliss, A.L. Metallomics 2012 Order out of Disorder ?C Working Cycle of an Intrinsically Unfolded Chaperone Reichmann, D., Xu, Y Cremers, C.M., Ilbert, M., Mitelman, R., Fitzgerald, M.C., and Jakob, U. Cell 2012 Slow Histidine H/D Exchange Protocol for Thermodynamic Analysis of Protein Folding and Stability using Mass Spectr