个人简介
2011-至今，泰山医学院，免疫学研究所所长，教授
2006-2010，美国艾默里大学，艾默里疫苗中心，博士后
2002-2005，浙江大学，肿瘤学，博士研究生
1996-2002，河南省人民医院，病理科，主治医师
1997-1999，第二军医大学，免疫学教研室，进修
1993-1996，湖北医科大学，病理学，硕士研究生
1988-1993，湖北医科大学，口腔医学系，本科生
学术荣誉与奖励
2014：山东省留学人员回国创业奖
2011：山东省有突出贡献的中青年专家
2011：泰山学者海外特聘专家
研究领域
从事树突状细胞相关的研究工作。以树突状细胞为中心，研究树突状细胞亚群以及树突状细胞亚群与其他天然免疫细胞的相互作用对获得性免疫反应的调节。特别关注树突状细胞在人类重大免疫相关性疾病中的作用和机理。
近期论文
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1. Li Y, Liu X, Duan W, Tian H, Zhu G, He H, Yao S, Yi S, Song W, Tang H. Batf3-dependent CD8α+ Dendritic Cells Aggravate Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages. EBioMedicine. 2017 Apr;18:188-198.
2. Shen Y, Chen L, Wang M, Lin D, Liang Z, Song P, Yuan Q, Tang H, Li W, Duan K, Liu B, Zhao G, Wang Y. Flagellar Hooks and Hook Protein FlgE Participate in Host Microbe Interactions at Immunological Level. Sci Rep. 2017 May 3;7(1):1433.
3. Hao J, Zhao J, Zhang S, Tong T, Zhuang Q, Jin K, Chen W, Tang H. Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery. Colloids Surf B Biointerfaces. 2016 Nov 1;147:376-86.
4. Si C, Zhang R, Wu T, Lu G, Hu Y, Zhang H, Xu F, Wei P, Chen K, Tang H, Yeretssian G, Xiong H. Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells. Oncotarget. 2016 Nov 15;7(46):74834-74845.
5. Xu Y, Liu Y, Yang C, Kang L, Wang M, Hu J, He H, Song W, Tang H.Macrophages transfer antigens to DCs by releasing exosomes containing dead cell-associated antigens partially through ceramide-dependent pathway to enhance CD4+ T cell response. Immunology. 2016 Oct;149(2):157-71.
6. He H, Geng T, Chen P, Wang M, Hu J, Kang L, Song W, Tang H. NK cells promote neutrophil recruitment in the brain during sepsis-induced neuroinflammation. Sci Rep. 2016 Jun 8;6: 27711.
7. Hu J, He H, Yang Z, Zhu G, Kang L, Jing X, Lu H, Song W, Bai B, Tang H. Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis. Neurosci Bull. 2016 Feb; 32(1):70-82.
8. Tang H, Cao W, Kasturi SP, Ravindran R, Nakaya HI, Kundu K, Murthy N, Kepler TB, Malissen B, Pulendran B. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol. 2010 Jul;11(7):608-17. Epub 2010 May 23. *Recommended as “must read” by Faculty of 1000
9. Kasturi SP, Skountzou I, Randy A, Koutsonanos D, Tang H, Nakaya H, Ravindran R, Stewart S, Alam M, Murthy N, Hogan RJ, Garcia-Sastre A, Compans R and Pulendran B. Programming the magnitude and persistence of antibody responses with innate immunity. Nature. 2011 Feb 24;470(7335):543-7.
10. Pulendran B, Tang H, Manicassamy S. Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol. 2010 Aug;11(8):647-55. Epub 2010 Jul 20. Invited Review.
11. Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol. 2008 Oct;9(10):1157-64. Epub 2008 Aug 31.
12. Pulendran B, Tang H, Denning TL. Division of labor, plasticity, and crosstalk between dendritic cell subsets. Curr Opin Immunol. 2008 Feb;20(1):61-7. Epub 2007 Dec 21. Review.
13. Huang X, Zhang M, Tang H, Ruo C, Cao X. Identification and characterization of DEDDL, a human-specific isoform of DEDD. Gene Expr. 2006: 13(3): 141-53.
14. Tang H, Guo Z, Zhang M, Wang J, Chen G, Cao X. Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10. Blood. 2006 Aug 15;108(4):1189-97. Epub 2006 Apr 20.
15. Guo Z, Zhang M, Tang H, Cao X. Fas signal links innate and adaptive immunity by promoting dendritic cell secretion of CC and CXC chemokines. Blood. 2005 Sep 15;106(6):2033-41. Epub 2005 Jun 7.
16. Zhang M*, Tang H*, Guo Z*, An H, Zhu X, Song W, Guo J, Huang X, Chen T, Wang J, Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol. 2004 Nov; 5(11):1124-33.
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