个人简介

2013-present, Assistant Professor, Dept. of Chemistry, Washington University in St. Louis 2011-2013, Postdoctoral Research Fellow, Dept. of Biological Chemistry & Molecular Pharmacology, Harvard Medical School

研究领域

Organic Chemistry/Biological Chemistry/Organic Synthesis/Natural Products/Antibiotics/Biosynthesis/Enzymes/Enzyme Inhibitors/Drug Delivery/Anticancer Agents/Diversity-Oriented Synthesis

Antibiotic Drug Discovery. Infectious diseases continue to be a leading cause of death worldwide and the rapid development of bacterial resistance to current antibiotic chemotherapies is one of the world’s most urgent health problems. Stepping up to this challenge, our lab is dedicated to the discovery of new antibacterial scaffolds and drug delivery systems that act against underexploited biological targets and overcome known resistance mechanisms. Our inspiration for new antibiotic therapeutics comes from structurally diverse microbial natural products, “Nature’s Medicine”, and relies on a coordinated effort of interdisciplinary approaches (organic synthesis, enzymology, spectroscopy, molecular biology, microbiology) to establish medicinal chemistry programs around unique, and sometimes complex, natural product molecular scaffolds.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Walsh, C. T.; Wencewicz, T. A. "Prospects for new antibiotics: A molecule-centered perspective." J. Antibiotics; Advanced Publication, June 12, 2013. DOI: 10.1038/ja.2013.49. Wencewicz, T. A.; Miller, M. J. ""Biscatecholate-monohydroxamate mixed ligand siderophore-carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii." J. Med. Chem. 2013, 56, 4044-4052. Wencewicz, T. A.; Long, T. E.; Möllmann, U.; Miller, M. J. "Trihydroxamate siderophore-fluoroquinolone conjugates are selective sideromycin antibiotics that target Staphylococcus aureus." Bioconjugate Chemistry 2013, 24, 473-486. Wencewicz, T. A.; Walsh, C. T. "P. syringae self protection from tabtoxinine-β-lactam by ligase TblF and acetylase Ttr." Biochemistry 2012, 51, 7712-7725. Walsh, C. T.; Wencewicz, T. A. "Flavoenzymes: Versatile catalysts in biosynthetic pathways." Nat. Prod. Rep. 2012, 30, 175-200. Wencewicz, T. A.; Oliver, A. G.; Miller, M. J. "Iron(III)-templated macrolactonization of trihydroxamate siderophores." Org. Lett. 2012, 14, 4390-4393. Wencewicz, T. A.; Yang, B.; Rudloff, J. R.; Oliver, A. G.; Miller, M. J. "N-O chemistry for antibiotics: Discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry." J. Med. Chem. 2011, 54, 6843-6858.