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研究领域

Antigene and Antisense Agents/Bioanalytical Chemistry/Biological Chemistry/Biophysical Chemistry/Cell Biology/DNA Photobiology/G-quadruplexes/Mass Spectrometry/Molecular Biology/Nanoparticles/NMR/Organic Chemistry/Organic Synthesis/Peptide Nucleic Acids/PET and Optical Imaging Agents/Physical organic chemistry/Polyamides/Prodrugs/Proteomics/siRNA

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Nucleic Acid Triggered Catalytic Drug Release, Zhaochun Ma, John-Stephen Taylor*, 2000 Proc. Natl. Acad. Sci. 97, 11159-63. Cai, J., Li, X., Yue, X., Taylor*, J. S., Nucleic Acid Triggered Fluorescent Probe Activation by the Staudinger Reaction. 2004 J. Am. Chem. Soc., 126,16324-5. Sun, X., Fang, H., Li, X., Rossin, R., Welch, M. J., Taylor*, J. S., MicroPET imaging of MCF-7 tumor in mice via unr mRNA-targeted peptide nucleic acids, 2005 Bioconjug. Chem. 16, 294-305 Vu, B., Cannistraro, V.J., Sun, L. and Taylor, J.S. DNA synthesis past a 5-methylC-containing cis-syn-cyclobutane pyrimidine dimer by yeast pol eta is highly nonmutagenic. 2006 Biochemistry, 45, 9327-35. Su DG, Kao JL, Gross ML, & Taylor JS Structure determination of an interstrand-type cis-anti cyclobutane thymine dimer produced in high yield by UVB light in an oligodeoxynucleotide at acidic pH 2008 J. Am. Chem. Soc. 130, 11328-11337. Fang, H., Zhang, K., Shen, G., Wooley, K.L. and Taylor, J.S. Cationic Shell-crosslinked Knedel-like (cSCK) Nanoparticles for Highly Efficient PNA Delivery. 2009 Molecular Pharmaceutics, in press. Wang, R. E.; Kao, J. L.-F.; Hilliard, C. A.; Pandita, R. K.; Roti Roti, J. L.; Hunt, C. R.; Taylor, J.-S. Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives J. Med. Chem. 2009, in press Ke Zhang, Huafeng Fang, Zhenghui Wang, Zhou Li, John-Stephen A. Taylor,* and Karen L. Wooley,* Structure-Activity Relationships of Cationic Shell-crosslinked Knedel-like Nanoparticles: Shell Composition and Transfection Efficiency/Cytotoxicity, Biomaterials, 2010, 1805-13. PMID: 19687218 PMCID: PMC2731805 Free PMC Article Kenjiro Asagoshia, Yuan Liua, Aya Masaokaa, Li Lanb, Rajendra Prasada, Julie K. Hortona, Ashley R. Brown, Xiao-hong Wang, Hussam M. Bdour, Robert W. Sobol, John-Stephen Taylor, Akira Yasui, and Samuel H. Wilson "DNA polymerase b-dependent long patch base excision repair of UV induced pyrimidine photoproducts in nucleotide excision repair deficient cells" DNA Repair 2010 9, 109-19. Dian Su, John-Stephen Taylor, Michael Gross. HPLC and Mass Spectrometric Characterization of a New Class of DNA Photoproducts Involving Reaction of Adjoining mC and A, Chem. Res. Toxicol. 2010 23, 474-9. PMCID: PMC2838963 [Available on 2011/3/15] Huafeng Fang, Yuefei Shen, John-Stephen A. Taylor, Native mRNA antisense-accessible sites library for the selection of highly effective antisense oligonucleotides, PNAs, and siRNAs" RNA 2010, 1429-35. Vincent Cannistraro, John-Stephen Taylor, Methyl CpG binding protein 2 (MECP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination, Nucl. Acids Res. 2010, in press. PMID: 20601406. Free article. Brown, J. A.; Zhang, L.; Sherrer, S. M.; Taylor, J. S.; Burgers, P. M.; Suo, Z. Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. J Nucleic Acids 2010 in press. PMCID: PMC2925389. Free PMC article. Song, Q., Cannistraro, V. J., and Taylor, J. S. (2010) Rotational position of a 5-methylcytosine-containing cyclobutane pyrimidine dimer in a nucleosome greatly affects its deamination rate. J Biol Chem. 2010, in press. PMID: 21160086. Free Article Identification of Quercetin Binding Proteins In Vivo with a Biotinylated Quercetin Photoaffinity Reagent, Rongsheng E.Wang, Clayton R. Hunt, Jiawei Chen, John-Stephen Taylor, submitted. Inhibition of Heat Shock Transcription Factor Binding and Heat Shock Protein 70 Induction in vivo by a Linear Polyamide Binding in a 1:1 C→N Mode, Rongsheng E. Wang, Raj K. Pandita, Jianfeng Cai, Clayton R. Hunt, John Stephen Taylor* submitted.

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