Rao, Jianghong - Stanford University - Department of Medicine

个人简介

Prof. Rao did his Ph.D. with George M. Whitesides and his postdoc with Roger Y. Tsien. He became an Assistant Professor at UCLA before joining Stanford. Ph.D., Harvard University, Chemistry (1999)

研究领域

Research Interests Research in the Rao lab uses physical, chemical and biological tools to develop novel imaging strategies. We develop new molecular probes to monitor specific biological targets under physiological settings, and in general our projects fit into one or more of the following three interconnected lines. 1. Enzyme activity-based in vivo imaging 2. In vivo protein and RNA labeling 3. New sensing and imaging technologies

近期论文

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Zixin Chen*, Min Chen*, Yunfeng Cheng*, Toshiyuki Kowada, Jinghang Xie, Xianchuang Zheng and Jianghong Rao. Exploring condensation reaction between aromatic nitriles and amnio thiols to form nanoparticles in cells for imaging the activity of protease and glycosidase. Angewandte Chemie International Edition. 2019 Dec (*Co-first author). doi: 10.1002/anie.201913314 Benjamin B. Kasten, Ke Jiang, Denzel Cole, Aditi Jani, Neha Udayakumar, G. Yancey Gillespie, Guolan Lu, Tingting Dai, Eben L. Rosenthal, James M. Markert, Jianghong Rao and Jason M. Warram. Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models. European journal of nuclear medicine and molecular imaging. 2019 Nov. doi: 10.1007/s00259-019-04607-x Paul Robert Neumann, Daniel L. Crossley, Michael Turner, Michael Ingleson, Mark Green, Jianghong Rao and Lea Ann Dailey. In Vivo Optical Performance of a New Class of Near-Infrared-Emitting Conjugated Polymers: Borylated PF8-BT. ACS Applied Materials & Interfaces. 2019 Dec, 11(50):46525-46535. doi: 10.1021/acsami.9b17022 Wei Wu, Jessica L. Klockow, Suchismita Mohanty, Kimberly S. Ku, Maryam Aghighi, Stavros Melemenidis, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Ning Zhao, Jürgen Schlegel, Edward E. Graves, Jianghong Rao, Paul M. Loadman, Robert A. Falconer, Sudip Mukherjee, Frederick T. Chin and Heike E. Daldrup-Link. Theranostic nanoparticles enhance the response of glioblastomas to radiation. Nanotheranostics. 2019; 3(4):299-310. doi:10.7150/ntno.35342 Xianchuang Zheng, Liyang Cui, Min Chen, Luis A. Soto, Edward E. Graves and Jianghong Rao. A Near-Infrared Phosphorescent Nanoprobe Enables Quantitative, Longitudinal Imaging of Tumor Hypoxia Dynamics during Radiotherapy. Cancer Research. 2019 Sep, 79(18):4787-4797. doi: 10.1158/0008-5472.CAN-19-0530 Guosheng Song, Xianchuang Zheng, Youjuan Wang, Xin Xia, Steven Chu and Jianghong Rao. A Magneto-Optical Nanoplatform for Multimodality Imaging of Tumors in Mice. ACS Nano. 2019, 13, 7, 7750-7758. doi: 10.1021/acsnano.9b01436 Adam J. Shuhendler, Lina Cui, Zixin Chen, Bin Shen, Min Chen, Michelle L. James, Timothy H. Witney, Magdalena Bazalova-Carter, Sanjiv S. Gambhir, Frederick T. Chin, Edward E. Graves and Jianghong Rao. [18F]-SuPAR: A Radiofluorinated Probe for Noninvasive Imaging of DNA Damage-Dependent Poly(ADP-ribose) Polymerase Activity. Bioconjugate Chemistry. 2019 30, 5, 1331-42. doi: 10.1021/acs.bioconjchem.9b00089 Maxim B. Prigozhin, Peter C. Maurer, Alexandra M. Courtis, Nian Liu, Michael D. Wisser, Chris Siefe, Bining Tian, Emory Chan, Guosheng Song, Stefan Fischer, Shaul Aloni, D. Frank Ogletree, Edward S. Barnard, Lydia-Marie Joubert, Jianghong Rao, A. Paul Alivisatos, Roger M. Macfarlane, Bruce E. Cohen, Yi Cui, Jennifer A. Dionne and Steven Chu. Bright sub-20-nm cathodoluminescent nanoprobes for electron microscopy. Nature Nanotechnology. 2019 May 14(5): 420-425. doi: 10.1038/s41565-019-0395-0 Antonio Meola, Jianghong Rao, Navjot Chaudhary, Guosheng Song, Xianchuang Zheng and Steven D. Chang. Magnetic Particle Imaging in Neurosurgery. World Neurosurgery. 2019 May 125:261-70. doi: 10.1016/j.wneu.2019.01.180 Antonio Meola, Jianghong Rao, Navjot Chaudhary, Mayur Sharma and Steven D. Chang. Gold nanoparticles for brain tumor imaging: a systematic review. Frontiers in Neurology. 2018 May 14; 9:328. doi: 10.3389/fneur.2018.00328 Zixin Chen and Jianghong Rao. Positron Emission Tomography Imaging of Tumor Apoptosis with a Caspase-Sensitive Nano-Aggregation Tracer [18F]C-SNAT. In: Dubey P. (eds) Reporter Gene Imaging. Methods in Molecular Biology. 2018; 1790:181-195. doi: 10.1007/978-1-4939-7860-1_14 Yunfeng Cheng*, Jinghang Xie*, Kyung-Hyun Lee, Rajiv L. Gaur, Aiguo Song, Tingting Dai, Hongjun Ren, Jiannan Wu, Zhaogang Sun, Niaz Banaei, Demir Akin and Jianghong Rao. Rapid and specific labeling of single live Mycobacterium tuberculosis with a dual-targeting fluorogenic probe. Science Translational Medicine. 2018 Aug 15;10(454). pii: eaar4470. DOI: 10.1126/scitranslmed.aar4470 (Cover story, *Co-first author) Stephen Adams and Jianghong Rao. Editorial Overview: Non-invasive molecular imaging: dedicated to the memory of Professor Roger Tsien. Current Opinion in Chemical Biology. 2018 Aug;45. DOI:10.1016/j.cbpa.2018.07.025 Antonio Meola, Jianghong Rao, Navjot Chaudhary, Mayur Sharma and Steven D. Chang. Gold Nanoparticles for Brain Tumor Imaging: A Systematic Review. Front Neurol. 2018 May 14;9:328. DOI:10.3389/fneur.2018.00328 Zixin Chen, Jianghong Rao. Positron Emission Tomography Imaging of Tumor Apoptosis with a Caspase-Sensitive Nano-Aggregation Tracer [18F]C-SNAT. Methods Mol Biol. 2018;1790:181-195. DOI:10.1007/978-1-4939-7860-1_14 Christopher M. Hartshorn, Michelle S. Bradbury, Gregory M. Lanza, Andre E. Nel, Jianghong Rao, Andrew Z. Wang, Ulrich B. Wiesner, Lily Yang and Piotr Grodzinski. Nanotechnology Strategies To Advance Outcomes in Clinical Cancer Care. ACS Nano. 2018 Jan 23;12(1):24-43. DOI:10.1021/acsnano.7b05108 Guosheng Song*, Min Chen*, Yanrong Zhang, Liyang Cui, Haibo Qu, Xianchuang Zheng, Max Wintermark, Zhuang Liu and Jianghong Rao. Janus Iron Oxides @ Semiconducting Polymer Nanoparticle Tracer for Cell Tracking by Magnetic Particle Imaging. Nano Letters 2018 Jan 10;18(1):182-189. DOI:10.1021/acs.nanolett.7b03829 (*Co-first author) Jingchao Li, Jianghong Rao and Kanyi Pu. Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy. Biomaterials. 2018 Feb;155:217-235. DOI: 10.1016/j.biomaterials.2017.11.025 Aiguo Song, Yunfeng Cheng, Jinghang Xie, Niaz Banaeib and Jianghong Rao. Intramolecular substitution uncages fluorogenic probes for detection of metallo-carbapenemase-expressing bacteria. Chemical Science. 2017 Nov 1;8(11):7669-7674. DOI: 10.1039/c7sc02416a Mingzhou Ye, Yuxin Han, Jianbin Tang, Ying Piao, Xiangrui Liu, Zhuxian Zhou, Jianqing Gao, Jianghong Rao and Youqing Shen. A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers. Advanced Materials. 2017 Oct;29(38). DOI: 10.1002/adma.201702342