Patti, Gary - Washington University in St. Louis

研究领域

Our laboratory is interested in the biochemical reactions that underlie fundamental physiological processes and associated metabolic derangements that cause disease. By using state-of-the-art mass spectrometers coupled with cutting-edge metabolomic technologies, we take a systems-level approach to study comprehensive metabolism and identify specific pathways that are altered in connection with particular phenotypes. We strive to translate our metabolomic findings into a physiological context through the use of classical biochemical tools and animal models as well as with the development of new technologies such as mass spectrometry-based metabolite imaging and whole-cell NMR. Our specific interests are outlined below.

近期论文

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Nikolskiy I, Patti GJ Discriminating Precursors of Common Fragments for Large-Scale Metabolite Profiling by Triple Quadrupole Mass Spectrometry Bioinformatics, in press, 2015 doi:10.1093/bioinformatics/btv085 Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA Ketogenesis Prevents Diet-Induced Fatty Liver Injury and Hyperglycemia J Clin Invest., 124(12), 5175-5190, 2014 doi:10.1172/JCI76388 Cho K, Mahieu NG, Ivanisevic J, Uritboonthai W, Chen Y-J, Siuzdak G, Patti GJ isoMETLIN: A Database for Isotope-Based Metabolomics Anal. Chem., 86(19), 9358-9361, 2014 doi:10.1021/ac5029177 Mahieu NG, Huang X, Chen Y-J, Patti GJ Credentialed Features: A Platform to Benchmark and Optimize Untargeted Metabolomic Methods Anal. Chem., 86(19), 9583-9589, 2014 doi:10.1021/ac503092d Chen Y-J, Hill S, Huang H, Taraboletti A, Cho K, Gallo R, Manchester M, Shriver LP, Patti GJ Inflammation Triggers Production of Dimethylsphingosine from Oligodendrocytes Neuroscience, 279(2014), 113-121, 2014 doi:10.1016/j.neuroscience.2014.08.011 Chen Y-J, Huang X, Mahieu NG, Cho K, Schaefer J, Patti GJ Differential Incorporation of Glucose into Biomass during Warburg Metabolism Biochemistry, 53(29), 4755-4757, 2014 doi:10.1021/bi500763u Cho K, Mahieu NG, Johnson SL, Patti GJ After the feature presentation: technologies bridging untargeted metabolomics and biology Current Opinion in Biotechnology, 28, 143-148, 2014 doi:10.1016/j.copbio.2014.04.006 Huang X, Chen Y-J, Cho K, Nikolskiy I, Crawford PA, Patti GJ X13CMS: Global Tracking of Isotopic Labels in Untargeted Metabolomics Anal. Chem., 86(3), 1632-1639, 2014 doi:10.1021/ac403384n Nikolskiy I, Mahieu NG, Chen Y-J, Tautenhahn R, Patti GJ An Untargeted Metabolomic Workflow to Improve Structural Characterization of Metabolites Anal. Chem., 85(16), 7713-7719, 2013 doi:10.1021/ac400751j Goeddel L, Patti GJ Maximizing the Value of Metabolomic Data Bioanalysis, 18, 2199-2201, 2012 doi:10.4155/BIO.12.210 Patti GJ, Yanes O, Siuzdak G Metabolomics: The Apogee of the Omic Triology Nature Reviews, 13(4), 263-269, 2012 doi:10.1038/nrm3314 Patti GJ, Yanes O, Shriver L, Courade JP, Tautenhahn R, Manchester M, Siuzdak G Metabolomics Implicates Altered Sphingolipids in Chronic Pain of Neuropathic Origin Nature Chemical Biology, 8, 232-234, 2012 doi:10.1038/nchembio.767 Patti GJ Separation Strategies for Untargeted Metabolomics Journal of Separation Science, 34(24): pages 3460-3469, 2011 doi:10.1002/jssc.201100532