个人简介

2013-present Associate Professor, Department of Chemistry, Washington University 2011-present Member, International Center for Advanced Renewable Energy & Sustainability (I-CARES), Washington University 2008-present Member, Division of Biological and Biomedical Sciences (DBBS), Washington University 2008-present, Assistant Professor of Chemistry, Washington University 2005-2008, NIH Postdoctoral Fellow, University of California, Berkeley

研究领域

Inorganic Chemistry/Bioinorganic Chemistry/Organometallic Chemistry/Organic Chemistry/Biological Chemistry/Biomimetic Oxidations/Renewable Energy Catalysis/Oxygen-Activating Metalloenzymes/Role of Transition Metal Ions in Neurodegenerative Diseases

Our research program uses inorganic chemistry, organic chemistry, and biological chemistry to address important metal-mediated processes with energy, biological, and medical relevance. An interdisciplinary, problem-based approach will be employed to synthesize and characterize new organic molecules and inorganic complexes, with the ultimate goal to tackle unsolved problems with broad implications to our society. Several research areas will be pursued, which are expected to attract students and postdocs with different research interests and to provide them with a broad knowledge base applicable in most chemistry careers.

近期论文

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Tang, F.; Rath, N. P.; Mirica, L. M.* "Stable Bis(trifluoromethyl)Nickel(III) Complexes", Chem. Comm., 2015, 51, 3113-3116; DOI: 10.1039/c4cc09594d. Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M.* "The Conformational Flexibility of the Tetradentate Ligand tBuN4 is Essential for the Stabilization of (tBuN4)PdIII Complexes", Inorg. Chem., 2014, 53, 13112-13129, DOI: 10.1021/ic5023054. Sharma, A. K.; Kim, J.; Prior, J. T.; Hawco, N. J.; Rath, N. P.; Kim, J.; Mirica, L. M.;* "Small Bifunctional Chelators that Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity", Inorg. Chem., 2014, 53, 11367-11376, DOI: 10.1021/ic500926c. Zheng, B.; Tang, F.; Luo, J.; Schultz, J. W.; Rath, N. P.; Mirica, L. M.* "Organometallic Nickel(III) Complexes Relevant to Cross-Coupling and Carbon-Heteroatom Bond Formation Reactions", J. Am. Chem. Soc., 2014, 136, 6499-6504; DOI: 10.1021/ ja5024749. Qu, F.; Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M.* "An Organometallic Pd(IV)-OH Complex Formed upon Aerobic Oxidation of a Pd(II) Precursor and Its C-O Bond Formation Reactivity", Chem. Comm., 2014, 50, 3036-3039; DOI: 10.1039/c3cc49387c. Sharma, A. K.; Pavlova, S. T.; Kim, J.; Kim, J.; Mirica, L. M.;* "The Effect of Cu2+ and Zn2+ on the Ab42 Peptide Aggregation and Cellular Toxicity", Metallomics, 2013, 5, 1519-1536; DOI: 10.1039/c3mt00161j. Zhang, Y.; Rempel, D. L.; Zhang, J.; Sharma, A. K.; Mirica, L. M.;* Gross M. L.* "Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation", Proc. Natl. Acad. Sci. U. S. A., 2013, 110, 14604-14609; DOI: 10.1073/pnas.1309175110. Luo, J.; Rath, N. P.; Mirica, L. M.* "Oxidative Reactivity of (N2S2)PdRX Complexes (R = Me, Cl; X = Me, Cl, Br): Involvement of Palladium(III) and Palladium(IV) Intermediate", Organometallics, 2013, 32, 3343-3353; DOI: 10.1021/om400286j. Khusnutdinova, J. R.; Luo, J.; Rath, N. P.; Mirica, L. M.* "Late First Row Transition Metal Complexes of a Tetradentate Pyridinophane Ligand: Electronic Properties and Reactivity Implications", Inorg. Chem., 2013, 52, 3920-3932, DOI: 10.1021/ic400260z. Mirica, L. M.;* Khusnutdinova, J. R., "Structure and Electronic Properties of Pd(III) Complexes", Coord. Chem. Rev., 2013, 257, 299-314. DOI: 10.1016/j.ccr.2012.04.030. Cascella, B.; Mirica, L. M.* "Kinetic Analysis of Iron-Dependent Histone Demethylases: a-Ketoglutarate Substrate Inhibition and Potential Relevance to the Regulation of Histone Demethylation in Cancer Cells", Biochemistry, 2012, 51, 8699-8701, DOI: 10.1021/bi3012466. Tang, F.; Qu, F.; Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M.* "Structural and Reactivity Comparison of Analogous Organometallic Pd(III) and Pd(IV) Complexes", Dalton Trans., 2012, 41, 14046-14050, DOI:10.1039/C2DT32127K. Tang, F.; Zhang, Y.; Rath, N. P.; Mirica, L. M.* "Detection of Pd(III) and Pd(IV) Intermediates during the Aerobic Oxidative C-C Bond Formation from a Pd(II) Dimethyl Complex", Organometallics, 2012, 31, 6690-6696. DOI: 10.1021/om300752w. Khusnutdinova, J. R.; Qu, F.; Zhang, Y.; Rath, N. P.; Mirica, L. M.* "Formation of the Pd(IV) Complex [(Me3tacn)PdIVMe3]+ through Aerobic Oxidation of (Me3tacn)PdIIMe2 (Me3tacn = N,N’,N’’-trimethyl-1,4,7-triazacyclononane)", Organometallics, 2012, 31, 4627-4630, DOI: 10.1021/om300426r. Article featured on the cover. Sharma, A. K.; Pavlova, S. T.; Kim, J.; Finkelstein, D.; Hawco, N. J.; Rath, N. P.; Kim, J.; Mirica, L. M.* "Bifunctional Metal-Binding Compounds for Controlling the Metal-Mediated Aggregation of the Ab42 Peptide", J. Am. Chem. Soc., 2012, 134, 6625-6636, DOI: 10.1021/ja210588m. Khusnutdinova, J. R.; Rath, N. P.; Mirica, L. M.* "The Aerobic Oxidation of a Pd(II) Dimethyl Complex Leads to Selective Ethane Elimination from a Pd(III) Intermediate", J. Am. Chem. Soc., 2012, 134, 2414-2422, DOI: 10.1021/ja210841f. Luo, J., Khusnutdinova J. R., Rath N., Mirica L. M.* "Unsupported d8-d8 Interactions in Cationic PdII and PtII Complexes: Evidence for a Significant Metal-Metal Bonding Character" Chem. Comm., Emerging Investigators issue 2012, in press, DOI:10.1039/C1CC15420F. Luo, J., Rath N., Mirica L. M.* "Dinuclear Co(II)Co(III) Mixed-Valence and Co(III)Co(III) Complexes with N- and O-Donor Ligands: Characterization and Water Oxidation Studies" Inorg. Chem., 2011, 50, 6152-6157. Khusnutdinova J., Rath N., Mirica L. M.* "Dinuclear PD(III) Complexes with a Single Unsupported Bridging Halide Ligand: reversible Formation from Mononuclear Pd(II) or Pd(IV) Precursors" Agnew. Chem Int. Ed.,2011, 50 5532-5536. Khusnutdinova J., Rath N., Mirica L. M.* "Stable Mononuclear Organometallic Pd(III) Complexes and Their C-C Bond Formation Reactivity" J. Am. Chem. Soc., 2010, 132, 7303-7305. Featured as "News of the Week" in Chem. & Eng. News, 2010, 88, 21, 9. Mirica, L. M.; McCusker, K. P.; Munos, J. W.; Liu, H. W.; Klinman, J. P.* "Probing the Nature of Reactive Fe/O2 Intermediates in Non-Heme Iron Enzymes through 18O Kinetic Isotope Effects." J. Am. Chem. Soc., 2008, 130, 8122-8123. Mirica, L. M.; Klinman, J. P.* "The Nature of O2 Activation by the Ethylene-Forming Enzyme ACC Oxidase." Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 1814-1819. Mirica, L. M.; Rudd, D. J.; Vance, M.; Solomon, E. I.;* Hedman, B.;* Hodgson, K. O.;* Stack, T. D. P.* "A m-h2:h2-Peroxodicopper(II) Complex with a Secondary Diamine Ligand: A Functional Model of Tyrosinase." J. Am. Chem. Soc., 2006, 128, 2654-2665. Mirica, L. M.; Vance, M.; Rudd, D. J.; Hedman, B.;* Hodgson, K. O.;* Solomon, E. I.;* Stack, T. D. P.* "Tyrosinase Reactivity in a Model Complex: An Alternative Hydroxylation Mechanism." Science, 2005, 308, 1890-1892. Featured as a perspective in Science, 2005, 308, 1876-1877 and a science concentrate in Chem. & Eng. News, 2005, 83, 26, 38. Mirica, L. M.; Ottenwaelder, X.; Stack, T. D. P.* "Structure and Spectroscopy of Copper–Dioxygen Complexes." Chem. Rev., 2004, 104, 1013-1046. Mirica, L. M.; Vance, M.; Rudd, D. J.; Hedman, B.;* Hodgson, K. O.;* Solomon, E. I.;* Stack, T. D. P.* "A Stabilized m-h2:h2-Peroxodicopper(II) Complex with a Secondary Diamine Ligand and Its Tyrosinase-like Reactivity." J. Am. Chem. Soc. 2002, 124, 9332-9333.