赵岚 - 中国科学院过程工程研究所

个人简介

赵岚，女，博士，1980年生。中国科学院过程工程研究所生化工程国家重点实验室副研究员，硕士生导师。本科和硕士均就读于天津大学，2004年毕业后进入中国科学院过程工程研究所工作，2012年获得中国科学院过程工程研究所生物化工博士学位。博士与工作阶段在马光辉研究员和苏志国研究员的带领下，一直从事先进生物分离材料、高性能层析（色谱）介质以及高效蛋白分离纯化技术等领域研究。在AnalyticalandBioanalyticalChemistry,JournalofSeparationScience,JournalofChromatographyA和JournalofChromatographyB等重要学术期刊发表论文20余篇，申请/授权专利6项，转让专利1项，分别于2016年和2013年获得中国分析测试协会科学技术奖青年奖和一等奖。

研究领域

近5年来，先后主持国家自然科学青年基金“类病毒颗粒组合层析一体化介质的制备与性能研究”（No.21306206），国家重大科学仪器设备开发专项子子课题“生物技术药物分离介质的研发和合成工艺”（No.2013YQ14040502），北京市自然科学基金面上项目“新型Nanodisc自组装色谱介质的制备及用于EV71病毒膜蛋白一步纯化和重构”（No.2172054），作为项目骨干承担国家重点研发计划“基于琼脂糖的高性能分离介质的研究开发”（No.2018YFC0311101）等多项国家和省部级课题。协助指导硕士研究生，全部发表SCI论文并顺利毕业。建立了针对疫苗、抗体、重组蛋白、酶等复杂大分子纯化介质的可控制备策略，广泛用于国内生物界科研院所、大专院校和企业，获得高度认可。授权和申请专利 [1]苏志国,马光辉,赵岚,李秀男,张松平.一种利用离子液体制备多糖微球的方法.CN2016110460636 [2]赵岚,黄永东,巩方玲.一种高流速多糖微球及其制备方法.CN201610806733.3 [3]赵岚,黄永东,巩方玲.一种高载量琼脂糖层析介质及其制备方法.CN201510685375.0 [4]马光辉，李强，巩方玲，黄永东，赵岚.一种聚苯乙烯类材料的亲水改性方法及其产品.201510671362.8 [5]赵岚，苏志国，闭静秀，周卫斌，王阳木，李岩，黄永东.一种琼脂糖疏水层析介质及其在纯化酵母表达HBsAg中的应用.授权号ZL200610001813.8 [6]闭静秀，周卫斌，苏志国，李岩，黄永东，赵岚，张焱.一种分离纯化汉逊酵母表达的重组乙肝表面抗原的方法.授权号ZL200610011217.8 成果转化情况 [1]闭静秀，周卫斌，苏志国，李岩，黄永东，赵岚，张焱.一种分离纯化汉逊酵母表达的重组乙肝表面抗原的方法.授权号ZL200610011217.8（2013年转让至华兰生物工程股份有限公司）

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1]HongwuZhang#,LanZhao#,*,YongdongHuang,KaiZhu,QibaoWang,RuiYang,ZhiguoSu,GuanghuiMa*.Uniformpolysaccharidecompositemicrosphereswithcontrollablenetworkbymicroporousmembraneemulsificationtechnique.AnalyticalandBioanalyticalChemistry,2018,410(18):4331-4341 [2]LanZhao#,*,WeiWei#,YongdongHuang,RongyueZhang,KaiZhu,DongxiaHao,ZhiguoSu,GuanghuiMa*.AnovelrProteinAchromatographicmediaforenhancingcleaning-in-placeperformance.JournalofImmunologicalMethods,2018,460:45-50 [3]LanZhao#,KaiZhu#,YongdongHuang*,QiangLi,XiunanLi,RongyueZhang,ZhiguoSu,QibaoWang,GuanghuiMa*.Enhancedbindingbydextran-graftingtoProteinAaffinitychromatographicmedia.JournalofSeparationScience,2017,40:1493-1499.(Cover) [4]LanZhao#,JingfeiZhang#,YongdongHuang,QiangLi,RongyueZhang,KaiZhu,JiaSuo,ZhiguoSu,ZhigangZhang,GuanghuiMa*.Efficientfabricationofhigh-capacityimmobilizedmetalionaffinitychromatographicmedia:Theroleofdextran-graftingprocessanditsmanipulation.JournalofSeparationScience,2016,39,1130-1136(Cover) [5]LanZhao,YongdongLiu,YinjueWang,YongdongHuang,XiunanLi,YanLi,GuanghuiMa,ZhiguoSu*.Determinationofleakagefromantibodyadsorbent:compositionanalysisandpHeffect,BiomedicalChromatography,2013,27:1089-1091 [6]LanZhao,YongdongLiu,YongdongHuang,XiunanLi,YinjueWang,YanLi,GuanghuiMa,ZhiguoSu*.Deliberatemanipulationofthesurfacehydrophobicityofanadsorbentforanefficientpurificationofagiantmoleculewithmultiplesubunits,JournalofSeparationScience,2011,34:3186-3193 [7]KunZhang#,QiangLi#,*,HongFan,SuningLi,YueSu,LanZhao,YongdongHuang,DanWang,ZhigangZhang,ZhiguoSu,GuanghuiMa*.Multi-layerdextran-decoratedpoly(glycidylmethacrylate)-co-divinylbenzenecopolymermatricesenablingefficientproteinchromatographicseparation.ReactiveandFunctionalPolymers,2017,112:45-52. [8]DongxiaHao,JiaGe,YongdongHuang,LanZhao,GuanghuiMa？,ZhiguoSu？.Microscopicinsightintoroleofproteinflexibilityduringionexchangechromatographybynuclearmagneticresonanceandquartzcrystalmicrobalanceapproaches,JournalofChromatographyA,2016,1438:65-75 [9]QiangLi,LanZhao,RongyueZhang,YongdongHuang,YanZhang,KunZhang,XuexingWu,ZhigangZhang,FanglingGong,ZhiguoSu,GuanghuiMa*.Functionalhydrophilicpolystyrenebeadswithuniformlysizeandhighcross-linkingdegreefacilitatedrapidseparationofexenatide,JournalofChromatographyB,2016,1017:129-135 [10]QiangLi*,RongyueZhang,DexiWu,YongdongHuang,LanZhao,DanWang,FanglingGong,LiangLi,HanQiu,GuanghuiMa*.Cell-nanoparticleassemblyfabricatedforCO2captureandinsitucarbonconversion.JournalofCO2Utilization,2016,13:17-23. [11]RongyueZhang,QiangLi,YongdongHuang,LanZhao,PeiliYe,GuanghuiMa*,ZhiguoSu.PreparationofPEGAgraftedpoly(chloromethylstyrene-co-ethyleneglycoldimethacrylate)monolithforhigh-efficiencysolidphasepeptidesynthesisundercontinuousflowtechniques.Polymer,2015,61:115-122 [12]ChenxuZhang,RongyueZhang,QiangLi,YongdongHuang,LanZhao,ZhiguoSu,FanglingGong,ZhengLv,HongyanSong,WeiLi,QipengYuan,GuanghuiMa*.Rapidoctreotideseparationfromsyntheticpeptidecrudemixturesbychromatographyonpoly(styrene-co-divinylbenzene)-basedreversedphases.SeparationandPurificationTechnology,2015,154:351-358 [13]RongyueZhang*,QiangLi,DekunJi,YitingPan,BoXu,YongdongHuang,LanZhao.Preparationofanovelpolymermonolithwithhighloadingcapacitybygraftingblockpoly(PEGA–mPEGA)forhigh-efficiencysolidphasesynthesis.ReactiveandFunctionalPolymers.2015,94:63-69 [14]XiunanLi,YaqiongLi,ChaoChen,DaweiZhao,XiaojunWang,LanZhao,HongShi,ZhiguoSu*.PoresizeanalysisfromlowfieldNMRspin-spinrelaxationmeasurementsofporousmicrospheres.JournalofPorousMaterials.2015,22:11-20 [15]YongdongHuang,JingxiuBi,LanZhao,GuanghuiMa,ZhiguoSu*.Regulationofproteinmultipointadsorptiononion-exchangeadsorbentanditsapplicationtothepurificationofmacromolecules,ProteinExpressionandPurification,2010,74:257-263 [16]YongdongHuang,JingxiuBi,YanZhang,WeibinZhou,YanLi,LanZhao,ZhiguoSu*.AhighlyefficientintegratedchromatographicprocedureforthepurificationofrecombinanthepatitisBsurfaceantigenfromHansenulapolymorpha,ProteinExpressionandPurification,2007,56(2):301-310 [17]WeibinZhou,JingxiuBi,LanZhao,YangmuWang,YanLi,YongdongHuang,GuanghuiMa,ZhiguoSu*.AhighlyefficienthydrophobicinteractionchromatographicabsorbentimprovedthepurificationofhepatitisBsurfaceantigen(HBsAg)derivedfromHansenulapolymorphacell,ProcessBiochemistry2007,42:751-756 [18]朱凯,赵岚,黄永东,李强,邱晗,王启宝,苏志国,马光辉*.葡聚糖接枝型ProteinA介质的层析性能提升.过程工程学报,2016,16(5):86-91 [19]张静飞，赵岚，黄永东，张志刚，马光辉*，苏志国.葡聚糖接枝型高载量金属螯合介质的制备与性能.过程工程学报,2015,15（1）:111-118 [20]张晨旭,李强,黄永东,赵岚,张荣月,巩方玲,宋翠,苏志国,袁其朋,马光辉*.聚二乙烯基苯微球介质制备及其在奥曲肽层析分离中的应用.过程工程学报,2015,15(3):481-488. [21]王阳木,闭静秀,赵岚,周卫斌,李岩,黄永东,张焱,林海,苏志国*.一种新型的琼脂糖疏水层析介质开发及其在重组乙肝表面抗原（CHO-HBsAg）分离纯化中的应用,生物工程学报,2006,22(2):278-284. [22]李瑞红,李岩,闭静秀,赵岚,周卫斌,黄永东,张焱,孙李靖,王化军,苏志国*.间臂和丁基密度对疏水层析分离纯化重组乙肝病毒表面抗原的影响,生物工程学报,2007,23(4):692-699 参与编写专著 [1]王佳兴,苏志国,马光辉.生化分离介质的制备及应用.化学工业出版社，2008