鲁白 - 清华大学

个人简介

鲁白教授于1982年在华东师范大学本科毕业。1990年获美国康乃尔(Cornel)大学医学院博士学位，师从著名神经生物学家，美国神经科学会主席Ira Black教授。1990至1993年美国洛克菲勒(Rockefeller)大学博士后，师从诺贝尔奖得主 Paul Greengard。 1993 至1996年任美国罗氏分子生物学研究所及哥伦比亚大学生物系助理教授。1996至2009年任美国国立健康研究院(NIH)，儿童发育研究所神经发育研究室主任。2003至2009年任NIH精神健康研究所(NIMH)基因、认知与精神研究部(GCAP)副主任。2009年至2013年任葛兰索史克中国研发部副总裁，负责整个生物部门学战略发展决策、神经退行性疾病的药物研发，以及包括商业发展和学术合作在内的对外交流工作。2013年10月起，全职到清华大学工作，任医学院药学系教授；2016年，任清华大学药学院教授。鲁白教授长期致力于神经营养因子和突触可塑性、以及神经与精神疾病方面的研究，他是该领域具有国际知名神经生物学家。荣誉和奖励 2014年：汤森路透集团神经科学和行为学“高被引科学家” 2007年：吴瑞奖 2006年：NIH院长奖 2003年：APAO奖 2003年：Mathilde Solowey奖 2001-2003年：Staff Recognition Award, NICHD. 1998年：白玉兰杰出科技人才奖 1989年：殷志浩大陆杰出青年科学家奖

研究领域

鲁白教授的实验室主要运用多种研究手段包括分子与细胞生物学，电生理，光遗传学，行为学，显微活体成像以及遗传学等，研究脑认知功能的神经环路，突触可塑性，神经与精神疾病、神经修复的分子生物学基础以及多种神经系统疾病的药物研发重点涵盖以下几个方面（1）BDNF在神经退行性疾病中的基础和转化研究（2）神经营养因子运用于神经系统疾病的药物研究（3）BDNF和突触可塑性参与的高级脑功能的研究（4）前额皮层的认知功能研究（5）非人灵长类动物模型

近期论文

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Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc. Natl. Acad. Sci. USA. 109, 15924-15929. J. Y. Kim, C. Liu, F. Zhang, X. Duan, Z. Wen, J. Song, E. Feighery, B. Lu, D. Rujescu, D. S. Clair, K. Christian, J. H. Callicott, D. R. Weinberger, H. Song and G. -l. Ming (2012) Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia. Cell. 5, 1051-1064. K. Zheng, J. J. An, F. Yang, W. Xu, Z. Xu, J. Wu, T. Hökfelt, A. Fisahn, B. Xu, and B. Lu (2011) TrkB Signaling in Parvalbumin-Positive Interneurons Is Critical for gamma-band network synchronization in hippocampus. Proc. Natl. Acad. Sci. USA. 108, 17201-17206. Y. Jiao, Z. Zhang, C. Zhang, X. Wang, K. Sakata, B. Lu, (co-corresponding author), and Q. -Q. Sun (2011) A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proc. Natl. Acad. Sci. USA. 108, 12131-12136. Y. Ji, Y. Lu, F. Yang, W. Shen, T. T. Tang, L. Feng, S. Duan, and B. Lu (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 13, 302-309. Fritsch, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen, and B. Lu (2010) Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning. Neuron 66, 198-204. T. T. Tang, F. Yang, B. Chen, Y. Lu, Y. Ji, K. Roche (co-corresponding author), and B. Lu (2009) Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. Proc. Natl. Acad. Sci. USA 106, 21395-400. Y. Ji, F. Yang, F. Papaleo (co-first author), H. Wang, W. Gao, D. R. Weinberger, and B. Lu (2009) Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc. Natl. Acad. Sci. USA 106, 19593–98. S. J, Huffaker, J. Chen, K. Nicodemus, F Sambataro, F. Yang, V. Mattay, B. Lipska, T. M. Hyde, J. Song, D. Rujescu, I. Giegling, K. Mayilyan, M. J. Proust, A. Soghoyan, G. Caforio, J. H. Callicott, A. Bertolino, A. Meyer-Lindenberg, J. Chang, Y. Ji , M. Egan, T. Goldberg, K. E. Kleinman, B. Lu, D. R. Weinberger (2009) A novel, primate-specific brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nature Medicine 5, 509-518. Commented in the same issue by Horvath and Mirnics, 488-590. K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen, B. Lu (2009) Critical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc. Natl. Acad. Sci. USA 106, 5942–5947. G. Nagappan, E. Zaitsev, V. V. Senatorov, Jr., J. Yang, B. Hempstead, B. Lu (2009) Control of extracellular cleavage of proBDNF by high-frequency neuronal activity. Proc. Natl. Acad. Sci. USA. 106, 1267-1272. Highlights by Katherine Whalley, Nature Rev. Neuroscie. 10, 168-169. Commented in Alzheimer Research Forum by Lucia Tapia-Arancibia as well as Margaret Fahnestock. J. J. An, K. Gharami, G. –Y. Liao, N. H. Woo, A. G. Lau, F. Vanevski, E. R. Torre, K. R. Jones, Y. Feng, B. Lu, B. Xu (2008) Distinct role of long 3’UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell 134, 175-187. X. Duan, J. H. Chang, S. Ge, R. L. Faulkner, J. Y. Kim, Y. Kitabatake, X. –b. Liu, C-H. Yang, D. Jordan, D. K. Ma, C. Y. Liu, H.-J. Cheng, G. –l. Ming, B. Lu (co-corresponding author), and H. Song (2007) Disrupted-In-Schizophrenia 1 regulates development of newly generated neurons in the adult brain. Cell. 130; 1146-1158. N. H. Woo, H.K. Teng, C. –J. Siao, C. Chiaruttini, P. T. Pang, T. A. Milner, B. L. Hempstead, and B. Lu (2005) Activation of p75 NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience 8, 1069-1077. Highlights by Morgan Sheng, Nature. 442, 4. Y. Ji, P. T. Pang, L. Feng, and B. Lu (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nature Neuroscience. 8, 164-172. Feature article in AfCS Nature the signaling gateway, Feb, 2005, commented by Myrto Raftopoulous. P. T. Pang, H. K. Teng, E. Zaitsev, N. Woo, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, and B. Lu (2004) Cleavage of ProBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 306, 487-491. Highlights by Rachel Jones, Nature Rev. Neuroscie. 5, 898. Commented in Sci STKE, 255 tw378. Worldwide news coverage.