何伟 - 清华大学

个人简介

何伟，1993至2001就读于中国科学技术大学化学系，本科生，硕士生。2001至2007年就读于美国University of Rochester，获得化学博士学位。2007至2008年就职于美国 Makoto Life Science, INC., 任研究科学家。2008至2010年就职于美国 Lexicon Pharmaceuticals, INC.，任研究科学家。2011年1月加入清华大学，任特别研究员，博士生导师。2017年晋升清华大学长聘教授。主要研究方向为（纳米）金属催化及药物分子发现。主要学术兼职包括从2016起任RSC Advances 杂志副主编。奖励 2013年清华大学“221”基础研究青年人才计划 2011，2015， 2016， Bayer Investigator Award 2012, 2013, Janssen Investigator Award

研究领域

面向当前创新药物研究中的挑战，何伟研究组主要在下述两个方向展开研究。（1）金属纳米有机催化。根据精细化学品和药物合成的需求，我们立足于金属纳米材料的可控合成，通过调控催化剂活性来实现高效高选择性的有机反应, 包括含硅化合物的合成化学和化学生物学研究; (2)基于片段的药物发现。我们结合片段筛选和基于结构的药物设计，发现特异性靶向新型、可药性低的蛋白靶点的功能有机小分子(如溴域蛋白、去泛素化酶等)，并展开化学生物学及早期药物发现工作。

近期论文

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Liu, C.; Zhang, Q.; Li, H.; Guo, S.; Xiao, B.; Deng, W.; Liu, L.; *He, W. Cu/Fe Catalyzed Intermolecular Oxidative Amination of Primary Benzylic C-H Bonds. Chem. Eur. J. 2016, DOI: chem.201600107. (HOT paper) Zhang, Q.-W.; An, K.; Liu, L.-C.; Guo, S.; Jiang, C.; Guo, H.; *He, W. Silacyclobutane: a New C-H Silylation Reagent. Angew. Chem. doi ： 10.1002/anie.201602376 Zhao, C.; Liu, L-C.; Wang, J.; Jiang, C.; Zhang, Q.-W.; *He, W. Rh(I)-Catalyzed Insertion of Allenes into C?C Bonds of Benzocyclobutenols. Org. Lett. 2016, 18, 328-331. Guo, H.; Chen, X.; Zhao, C.; *He, W. Suzuki-type Cross Coupling between Aryl Halides and Silylboranes for the Syntheses of Aryl Silanes. Chem. Commun. 2015, 51, 17410 – 17412. Ji, Y.; Wu, Y.; Zhao, G.; Wang, D.; Liu, L.; He, W.; *Li, Yadong. Porous bimetallic Pt-Fe nanocatalysts for highly efficient hydrogenation of acetone. Nano Research 2015. 8, 2706-2713. Zhang, Q.; An, K.; *He, W. Rh Catalyzed Enantioselective Intramolecular C-H Silylation for the Syntheses of Planar Chiral Metallocene Siloles. Angew. Chem. Int. Ed., 2015, 54, 6918-6921. Guo, H.; Xiuling Y;, Zhi, Y.; Li，Z.; Wu, C.; Zhao, C.; Wang, J.; Yu, Z.; *Ding, Y.; *He, W.; Li. Y. Nanostructuring Gold Wires for Highly Durable Nanocatalysts toward Selective reduction of nitro compounds and azides with organosilanes. Nano Research 2015, 8, 1365-1372 (Cover story) Xiao, B.; Niu, Z.; Wang, Y.; Jia, W.; Shang, J.; Zhang, L.; Wang, D.; Fu, Y.; Zeng, J.; He, W.; Wu, K.; Li, J.; Yang, J.; *Liu, L.; *Li, Y. Copper Nanocrystal Plane Effect on Stereoselectivity of Catalytic Deoxygenation of Aromatic Epoxides. J. Am. Chem. Soc. 2015, 137, 3791-3794. Zhang, Q.; An, K.; *He, W. Catalytic Synthesis of π-Conjugated Silole through Si-C (sp3) Bond Activation. Synlett, 2015, 26, 1145-1152. Dang, S.; Wu, S.; Wang, J.; Li, H.; Huang, M.; He, W.; Li, Y.; Wong, C. C. L.; *Shi, Y. Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH. PNAS 2015, 112, 3344-3349. Zhao, C.; Jiang, C.; Wang, J.; Wu, C.; Zhang, Q.; *He, W. Enantioselective Syntheses of α-Silyl Amines via a Copper-N-HeterocyclicCarbene Catalyzed Nucleophilic Silicon Transfer to Imines. Asian. J. Org. Chem. 2014, 3, 851-855. (Cover story) Zhang, Z.; Chen, Y.; He, S.; Zhang, J.; Xu, X.; Yang, Y.; Nosheen, F.; Saleem, F.; He, W.;*Wang, X. Hierarchical Zn/Ni-MOF-2 Nanosheet-Assembled Hollow Nanocubes for Multicomponent Catalytic Reactions. Angew. Chem. Int. Ed., 2014, 53, 12517-12521. Zhang, Q.; An, K.; *He, W. Rh Catalyzed Tandem Cyclization/Si-C Activation Reaction for the Synthesis of Siloles. Angew. Chem. Int. Ed. 2014, 53, 5667-5671. Zhang, Z.; Chen, Y.; Xu, X.; Zhang, J.; Xiang, G.; He, W.; *Wang, X. Well-Defined Metal-Organic Framework Hollow Nanocages. Angew. Chem. Int. Ed., 2014, 53, 429-433. Li, L.; Niu, Z.; Cai, S.; Zhi, Y.; Li, H.; Rong, H.; Liu, L.; Liu, L.; *He, W.; *Li, Y. A PdAg Bimetallic Nanocatalyst for Selective Reductive Amination of Nitroarenes. Chem. Comm. 2013, 49, 6843. Zhang, Q.; Cai, S.; Li, L.; Chen, Y.; Rong, H.; Niu, Z.; Liu, J.; *He, W.; *Li, Y. Direct Syntheses of Vinyl Ethers from Benzyl Alcohols via Ag Nanoparticles Catalyzed Tandem Aerobic Oxidation. ACS Catalysis, 2013, 3, 1681-1684. Liu, J.; *Liu, C.; *He, W. Fluorophores and Their Applications as Molecular Probes in Living Cells. Current Organic Chemistry 2013, 17, 564-579. Huang, W.; Choi, W.; Chen, Y.; Zhang, Q.; Deng, H.; He, W.; *Shi, Y. A Proposed Role for Glutamine in Cancer Cell Growth through Acid Resistance. Cell Research 2013, 23, 724-727. Cai, S.; Duan, H.; Rong, H.; Wang, D.; Li, L.; *He, W.; *Li, Y. Highly Active and Selective Catalysis of Bimetallic Rh3Ni1 Nanoparticles in the Hydrogenation of Nitroarenes ACS Catalysis, 2013, 3, 608-612. Cai, S.; Rong, H.; Yu, X.; Liu, X.; Wang, D.; *He, W.; *Li, Y. Room Temperature Activation of Oxygen by Monodispersed Metal Nanoparticles: Oxidative Dehydrogenative Coupling of Anilines for Azobenzene Syntheses. ACS Catalysis, 2013, 3, 478-486. Wu, Y.; Cai, S.; Wang, D.; * He, W.; *Li, Y. Syntheses of Water-Soluble Octahedral, Truncated Octahedral and Cubic Pt?Ni Nanocrystals and Their Structure?Activity Study in Model Hydrogenation Reactions. J. Am. Chem. Soc. 2012. 134, 8975-8981. Niu, Z.; Peng, Q.; Zhuang, Z.; *He, W.; *Li, Y. Evidence of an Oxidative-Addition-Promoted Pd-Leaching Mechanism in the Suzuki Reaction by Using a Pd-Nanostructure Design. Chem. Eur. J. 2012, 18, 9813-9817.