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个人简介

教育背景 09/2000-01/2005: 工学博士,清华大学,材料物理与化学专业 09/1996-07/2000: 工学学士,清华大学,材料科学与工程专业 工作履历 12/2013至今:研究员,博士生导师,清华大学材料学院 01/2009-12/2013: 副研究员,清华大学材料学院 01/2008-12/2008: 讲师,清华大学材料科学与工程系 05/2006-01/2008: 博士后,美国麻省理工学院(MIT),生物医学工程中心 (Center for Biomedical Engineering) 07/2005-05/2006: 博士后,美国罗切斯特大学医学院(University of Rochester Medical Center),骨科研究中心 (Center for Musculoskeletal Research) 学术兼职 Co-Editor-in-Chief, SCI国际期刊Tissue Engineering C Editor, SCI国际期刊Frontier of Materials Science Editor,SCI国际期刊Regenerative Biomaterials Editor, 国际期刊Biomaterials Research 中国生物材料学会,常务理事 中国生物材料学会神经修复材料分会,主任委员 中国生物材料学会青年委员会,委员 中国生物材料学会骨修复材料与器械分会,委员 中国生物材料学会再生医学材料分会,委员 中国生物材料学会海洋生物材料分会,委员 中国材料研究会青年工作委员会,常务理事 中国材料研究会外事工作委员会,委员 中国硅酸盐学会特种陶瓷分会,理事 中国复合材料学会生物医用复合材料分会,委员 中国机械工程学会表面工程分会生物材料表面工程专委会委员 中国医师协会骨科医师分会骨科技术创新与转化工作委员会委员 中国研究型医院学会技术创新与转化分会骨科生物材料与内置物学组委员 中国研究型医院学会神经再生与修复专业委员会周围神经损伤与修复学组委员 全国外科植入物和矫形器械标准化技术委员会组织工程医疗器械产品分技术委员会骨再生标准工作组专家 中国抗衰老促进会交叉学科专业委员会委员 中国科协先进材料学会联合体第一届青年工作委员会委员 中国医学救援协会整合康复医学分会,委员 中国医促会生物医用材料学组,委员 中国医促会肿瘤整形外科与功能性外科分会,委员 中国卫生经济学会老年健康专业委员会,理事 中国医药质量管理协会临床试验及大数据质量管理分会医学生物信息学专委会,委员 奖励与荣誉 2021年中国材料研究学会科学技术奖一等奖;项目名称:生物可降解材料的性能调控及新型器件研究(第二完成人) 2021年中华医学科技奖一等奖 (202101127);项目名称:骨盆髋臼骨折核心救治体系的创建于临床应用;(第四完成人) 2021年北京市科学技术进步奖二等奖;项目名称:可塑性骨填充材料的创新关键技术建立及推广应用;(第七完成人) 2019年:“庆祝中华人民共和国成立70周年”纪念章 2014年山东省科技进步一等奖(JB2014-1-19-R04);项目名称:带肋间神经的肋骨肌皮瓣移植修复下颌骨缺损的基础研究与临床应用;(第四完成人) 2011年国家自然科学二等奖(2011-Z-108-2-03-R02);项目名称:生物矿化纤维的分级组装机理研究(第二完成人) 2011年中华医学科技奖三等奖 (201103069P0804);项目名称:用组织工程技术修复中枢神经系统损伤的实验研究(第四完成人) 2010年北京市科学技术奖二等奖 (2010材-2-004-02);项目名称:生物矿化纤维的分级组装机理研究;(第二完成人) 2013 年度教育部“新世纪优秀人才” 2012 年度清华大学“学术新人奖” 2010年:第12届霍英东教育基金会青年基金奖(霍英东教育基金会) 2016宝钢优秀教师奖(宝钢教育基金会) 2016年:清华大学“刘冰奖”(清华大学) 2015年清华大学优秀班(级)主任一等奖 2009-2010年度北京高校优秀辅导员(中国北京市教委) 2009.12:首都国庆60周年群众游行优秀工作者称号(首都国庆60周年群众游行指挥部) 2009年:清华大学“刘述礼育才奖”(清华大学) 2003年:清华大学“一二九优秀辅导员奖”(清华大学)

研究领域

生物材料、组织工程与再生医学

近期论文

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Duan GM, Li CL, Yan XQ, Yang SH, Wang S, Sun XD, Zhao LY, Song TX, Pan YW*, Wang XM*. Construction of a mineralized collagen nerve conduit for peripheral nerve injury repair. Regenerative Biomaterials. 2022. In press. Ye WL, Yang Z, Cao FY, Li H, Zhao TY, Zhang H, Zhang Z, Yang SH, Zhu JJ, Liu Z, Zheng JC, Liu HY, Ma GW*, Guo QY*, Wang XM*. Articular Cartilage Reconstruction with TGF-beta 1-Simulating Self-Assembling Peptide Hydrogel-Based Composite Scaffold. Acta Biomaterialia. 2022, 146, 94-106. Zhu JJ, Yang SH, Qi YD, w/Wang XM*. Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model. Science Advances. 2022, 8(13), eabk0011. Chai Y, Zhao H, Yang SH, Gao XH, Cao Z, Lu JJ, Sun QL, Liu W, Zhang Z, Yang JY, Wang XL, Chen TY, Kong XD, Mikos AG, Zhang XH, Zhang YQ, Wang XM*. Structural alignment guides oriented migration and differentiation of endogenous neural stem cells for neurogenesis in brain injury treatment. Biomaterials. 2022, 280, 121310. Zheng JC, Zhao ZJ, Yang YD, Wang S, Zhao YG, Xiong Y, Yang SH, Qiu ZY, Song TX, Zhang CY, and Wang XM*. Biphasic mineralized collagen based composite scaffold for cranial bone regeneration in developing sheep. Regenerative Biomaterials. 2022, 9, rbac004. Xiong Y, Yang YL, Gao YS, Wang XM*, Yu X. Histological changes of cervical disc tissue in patients with degenerative ossification. J. Korean Neurosurg. Soc. 2022, 65(2): 186-195. Zheng JC, Yang CY, Wang XM*. Blow-spun collagen nanofibrous spongy membrane: preparation and characterization. Tissue Engineering Part C. 2022, 28(1): 3-11. Cao Z, Man WT, Xiong YH, Guo Y, Yang SH, Liu DK, Zhao H, Yang YD, Yao SL, Li CZ, Zhao LY, Sun XD, Guo H, Wang GH, Wang XM*. White matter regeneration induced by aligned fibrin nanofiber hydrogel contributes to motor functional recovery in canine T12 spinal cord injury. Regenerative Biomaterials. 2022, 9, rbab069. Yang SH, Zhu JJ, Lu CF, Chai Y, Cao Z, Lu JJ, Zhang Z, Zhao H, Huang YY, Yao SL, Kong XD, Zhang PX, and Wang XM*. Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery. Bioactive Materials. 2022, 8, 529-544. Zhang Z, Chai Y, Zhao H, w/Wang XM*. Crosstalk between PC12 cells and endothelial cells in an artificial neurovascular niche constructed by a dual-functionalized self-assembling peptide nanofiber hydrogel. Nano Research, 2022, 15, 1433-1445. Mu XD, Liu HW, Yang SH, Li YF, Xiang L, Hu M*, and Wang XM*. Chitosan Tubes Inoculated with Dental Pulp Stem Cells and Stem Cell Factor Enhance Facial Nerve-Vascularized Regeneration in Rabbits. ACS Omega. 2022, 7(22): 18509-18520. Wang YF, Yan ZW, Liu WJ, Liu CL, Xu N, Wu YX, Sun FB, Wang XM, Qian Y, Jiang L, Sun XD. Biomechanically-Adapted Immunohydrogels Reconstructing Myelin Sheath for Peripheral Nerve Regeneration. Advanced Healthcare Materials. 2022, 11(20), 2201596. Li C, Lv HZ, Du YW, Zhu WB, Yang WJ, Wang XM, Wang J, Chen W. Biologically modified implantation as therapeutic bioabsorbable materials for bone defect repair. Regenerative Therapy. 2022, 19, 9-23. Han QQ, Wang R, Wang XM*. Standardization and supervision of tissue engineered medical products in China. Tissue Engineering Part C. 2021, 27(12), 635-638. He YZ, Li YY, Zuo EJ, Chai SL, Ren X, Fei T, Ma GW*, Wang XM*, Liu HY*. A novel anti-bacterial titanium modification with a sustained release of Pac-525. Nanomaterials. 2021, 11(12), 3306. Man WT, Yang SH, Cao Z, w/Wang XM*. A multi-modal delivery strategy for spinal cord regeneration using a composite hydrogel presenting biophysical and biochemical cues synergistically. Biomaterials. 2021, 276: 120971. Zhang ZJ, Kou N, Ye WL, Wang S, Lu JJ, Lu Y, Liu HY*, and Wang XM*. Construction and Characterizations of Antibacterial Surfaces Based on Self-Assembled Monolayer of Antimicrobial Peptides (Pac-525) Derivatives on Gold. Coatings. 2021, 11(9), 1014. Mu XD, Sun XY, Yang SH, Pan S, Sun JX, Niu YM*, He LN, Wang XM*. Chitosan Tubes Prefilled with Aligned Fibrin Nanofiber Hydrogel Enhance Facial Nerve Regeneration in Rabbits. ACS Omega. 2021, 6(40), 26293-26301. Zhu JJ, Yang SH, Yang YT, Yao T, Liu G, Fan SW, Zhao H, Cui FZ, Wang XM*, Jiang GQ*, and Fang XQ*. Modified poly(methyl methacrylate) bone cement in the treatment of Kummell disease. Regenerative Biomaterials. 2021, 8(1), rbaa051. Jiang L, Liu ZQ, Wang ZY, w/Wang XM. Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials. Bioactive Materials. 2021, 5(3): 613-626. Yang CY, Huang WY, Chen LH, w/Wang XM. Neural tissue engineering: the influence of scaffold surface topography and extracellular matrix microenvironment. Journal of Materials Chemistry B. 2021, 9(3): 567-584. Lu JS, Guo ZH, Xiu WS, Chi YJ, Xu WL, Guo XX, Guo XH, Ye JL, Xu BH, Zheng R, Sun XD, Wang XM, Che SL, Yu J, and Zhao LY. ACS Applied Materials & Interfaces. 2021, 13(30): 35484-35493. Guo XX, Guo ZH, Lu JS, Xie WS, Zhong QZ, Sun XD, Wang XM, Wang JY, Liu M and Zhao LY. Nanoscale. 2021, 13, 14525. Mushtaq A, Zhao RB, Luo DD, w/Wang XM. Magnetic hydroxyapatite nanocomposites: The advances from synthesis to biomedical applications. Materials & Design. 2021, 197, 109269. Wu J, Yao SL, Zhang H, Man WT, Bai ZL, Zhang F, Wang XM, Fang DN, and Zhang YH. Liquid Crystal Elastomer Metamaterials with Giant Biaxial Thermal Shrinkage for Enhancing Skin Regeneration. Advanced Materials. 2021, 33(45):2106175. Wu LY, Wu YL, Che X, Luo DD, Lu JJ, Zhao RB, Iqbal MZ, Zhang Q, Wang XM, and Kong XD. Characterization, antioxidant activity, and biocompatibility of selenium nanoparticle-loaded thermosensitive chitosan hydrogels. Journal of Biomaterials Science-Polymer Edition. 2021, 32(10): 1370-1385. Yi Q, Feng XY, Zhang CM, Wang XM, et al. Comparison of dynamic mechanical properties of dentin between deciduous and permanent teeth. Connective Tissue Research. 2021, 62(4): 402-410. Yang SH, Wang C, Zhu JJ, w/Wang XM*. Self-assembling peptide hydrogels functionalized with LN- and BDNF- mimicking epitopes synergistically enhance peripheral nerve regeneration. Theranostics. 2020, 10(18): 8227-8249. Zhu JJ, Yang SH, Cai KW, w/Wang XM*. Bioactive poly (methyl methacrylate) bone cement for the treatment of osteoporotic vertebral compression fractures. Theranostics. 2020, 10(14): 6544-6560. Wang S, Yang YD, Wang RH, Kong XD, Wang XM*. Mineralization of calcium phosphate controlled by biomimetic self-assembled peptide monolayers via surface electrostatic potentials. Bioactive Materials. 2020, 5(2): 387-397. Wang S, Yang YD, Koons GL, Mikos AG, Qiu ZY, Song TX, Cui FZ, and Wang XM*. Tuning pore features of mineralized collagen/PCL scaffolds for cranial bone regeneration in a rat model. Materials Science & Engineering C. 2020, 106, 110186. Cao Z, Yao SL, Xiong YH, w/Wang XM*. Directional axonal regrowth induced by an aligned fibrin nanofiber hydrogel contributes to improved motor function recovery in canine L2 spinal cord injury. Journal of Materials Science-Materials in Medicine. 2020, 31(5), 40. He YZ, Jin YH, Ying YY, w/Wang XM*. Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair. Regenerative Biomaterials. 2020, 7(5): 515-525. Liu Z, Ye WL, Zheng JC, w/Wang XM*. Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release. Regenerative Biomaterials. 2020, 7(4): 381-390. Rao F, Wang YH, Zhang DY, w/Wang XM*, et al. Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats. Theranostics. 2020, 10(4): 1590-1603. Wang L, Lu CF, Yang SH, w/Wang XM. A fully biodegradable and self-electrified device for neuroregenerative medicine. Science Advances. 2020, 6(50), eabc6686. Xu N, Yan H, Jiao X, w/Wang XM. Effect of OH- concentration on Fe3O4 nanoparticle morphologies supported by first principle calculation. Journal of Crystal Growth. 2020, 547, 125780. Wei YJ, Liu ZQ, Zhu X, w/Wang XM. Dual directions to address the problem of aseptic loosening via electrospun PLGA @ aspirin nanofiber coatings on titanium. Biomaterials. 2020, 257, 120237. Yang YD, Zhao H, Chai Y, w/Wang XM. A comparison study between hybrid surgery and anterior cervical discectomy and fusion for the treatment of multilevel cervical spondylosis A SYSTEMATIC REVIEW AND META-ANALYSIS. Bone & Joint Journal. 2020, 102B(8), 981-996. Yan D, Wu X, Pei JY, Wu CC, Wang XM, Zhao HY. Construction of g-C3N4/TiO2/Ag composites with enhanced visible-light photocatalytic activity and antibacterial properties. Ceramics International. 46(1): 696-702. Sun CC, Chu XC, Yan SH, w/Wang XM. Influence of input signal on injection performance for needle driven piezoelectric micro-jet device. Microsystem Technologies. 2020, 27(5), 2009-2019. Yin HY, Strunz F, Yan ZX, w/Wang XM. et al. Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerative human tendon stem/progenitor cells. Biomaterials. 2020, 236, 119802. Luo KF, Jiang GQ, Zhu JJ, w/Wang XM. Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients. Regenerative Biomaterials. 2020, 7(1), 29-34. Luo X, Yao SL, Zhang HJ, w/Wang XM, et al. Biocompatible nano-ripples structured surfaces induced by femtosecond laser to rebel bacterial colonization and biofilm formation. Optics and Laser Technology. 2020, 124, 105973. Yao SL, He F, Cao Z, w/Wang XM, et al. Mesenchymal Stem Cell-Laden Hydrogel Microfibers for Promoting Nerve Fiber Regeneration in Long-Distance Spinal Cord Transection Injury. ACS Biomaterials Science & Engineering. 2020, 6(2): 1165-1175. Lu JJ, Yan XQ, Sun X, Shen XZ, w/Wang XM*. Synergistic effects of dual-presenting VEGF- and BDNF-mimetic peptide epitopes from self-assembling peptide hydrogels on peripheral nerve regeneration. Nanoscale 2019, 11, 19943-19958. Lu JJ, Guan FY, Cui FZ, Sun XD, Zhao LY, Wang Y*, and Wang XM*. Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats. Regenerative Biomaterials. 2019, 6(6),325-334. Yang SH, Cao Z, Zhu JJ, Zhang Z, Zhao H, Zhao LY, Sun XD, Wang XM*. In vitro monolayer culture of dispersed neural stem cells on the E-Cadherin-based substrate with long-term stemness maintenance. ACS Omega. 2019, 4(19), 18136-18146. Zhao H, Sun QL, Duan LJ, w/Wang XM*. Is cell transplantation a reliable therapeutic strategy for spinal cord injury in clinical practice? A systematic review and meta-analysis from 22 clinical controlled trials. European Spine Journal. 2019, 28(5), 1092-1112. Li M, Liu JH, Cui X, w/Wang XM*, et al. Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection. Regenerative Biomaterials. 2019, 6(6): 373-381. Liao BS, Xing FY, Wang D, w/Wang XM. Effect of in vitro collagen fibrillogenesis on Langmuir-Blodgett (LB) deposition for cellular behavior regulation. Colloids and Surfaces B-Biointerfaces. 2019, 179: 48-55. Xie WS, Guo ZH, Cao ZB, w/Wang XM. Manganese-Based Magnetic Layered Double Hydroxide Nanoparticle: A pH-Sensitive and Concurrently Enhanced T-1/T-2-Weighted Dual-Mode Magnetic Resonance Imaging Contrast Agent. ACS Biomaterials Science & Engineering. 2019, 5(5): 2555-2562. Gang FL, Yan H, Ma CY, Jiang L, Gu YY, Liu ZY, Zhao LY, Wang XM, Zhang JW, Sun XD. Robust magnetic double-network hydrogels with self-healing, MR imaging, cytocompatibility and 3D printability. Chemical Communications. 2019, 55(66): 9801-9804. Ma CY, Jiang L, Wang YJ, w/Wang XM. 3D Printing of Conductive Tissue Engineering Scaffolds Containing Polypyrrole Nanoparticles with Different Morphologies and Concentrations. Materials. 2019, 12(15): 2491. Mikos AG, Fisher JP, Schenke-Layland K, Shin H, Jansen JA, Wang XM, Liebert MA. Tissue Engineering: Celebrating 25 Years in Publication and Collaboration. Tissue Engineering Part A. 2019, 25(7-8), 513-514. Jiang L, Wang YJ, Liu ZQ, w/Wang XM. Three-Dimensional Printing and Injectable Conductive Hydrogels for Tissue Engineering Application. Tissue Engineering Part B-Reviews. 25(5): 398-411. Li M, Li SF, Liu JH, w/Wang XM. Sustained-release of sclerostin single-chain antibody fragments using poly(lactic-co-glycolic acid) microspheres for osteoporotic fracture repair. Journal of Biomedical Materials Research Part A. 2019, 107(8): 1832-1840. Yan H, Shang WT, w/Wang XM. Neoadjuvant nano-photothermal therapy used before operation effectively assists in surgery for breast cancer. Nanoscale. 2019, 11(2): 706-716. Liu ZQ, Hao Ys, w/Wang XM. A novel and facile prepared wound dressing based on large expanded graphite worms. Journal of Materials Research. 2019, 34(4): 490-499. Zhang K, Xiao XF, Wang XM, Yan YB, Li XM. Topographical patterning: characteristics of current processing techniques, controllable effects on material properties and co-cultured cell fate, updated applications in tissue engineering, and improvement strategies. Journal of Materials Chemistry B. 2019, 7(45): 7090-7109. Lu JJ, Shen XZ, Sun X, w/ Wang XM*. Increased Recruitment of Endogenous Stem Cells and Chondrogenic Differentiation by a Composite Scaffold Containing Bone Marrow Homing Peptide for Cartilage Regeneration. Theranostics. 2018, 8(18): 5039-5058. Lu JJ, Sun X, Yin HY, w/ Wang XM*. A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration. Nano Research. 2018, 11(9): 4599-4613. Wang S, Zhao ZJ, Yang YD, Mikos AG, Qiu ZY, Song TX, Cui FZ, Wang XM*, Zhang CY. A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep. Regenerative Biomaterials. 2018, 5, 283-292. Cao Z, Wang D, Li YS, w/Wang XM*. Effect of nanoheat stimulation mediated by magnetic nanocomposite hydrogel on the osteogenic differentiation of mesenchymal stem cells. Science China-Life Sciences. 2018, 61(4): 448-456. Lu JJ, and Wang XM*. Biomimetic Self-Assembling Peptide Hydrogels for Tissue Engineering Applications. Advances in Experimental Medicine and Biology. 2018, 1064: 297-312. Xie WS, Gao Q, Wang D, Guo ZH, Gao F, Wang XM, et al. Doxorubicin-loaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging-guided chemo-photothermal therapy of breast cancer. Nano Research. 2018, 11(5): 2470-2487. Xie WS, Guo ZH, Gao F, w/Wang XM. Shape-, size- and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics. Theranostics. 2018, 8(12): 3284-3307. Wang JY, Yan H, Liu ZQ, w/Wang XM. Langmuir-Blodgett self-assembly of ultrathin graphene quantum dot films with modulated optical properties. Nanoscale. 2018, 10(41): 19612-19620. Sun X, Yin H, Wang Y, Lu J, Shen X, w/Wang XM*, Peng J*. In situ articular cartilage regeneration through endogenous reparative cell homing using a functional bone marrow-specific scaffolding system. ACS Appl. Mater. Interfaces. 2018, 10(45): 38715-38728. Lu CF, Wang Y, Yang SH, w/ Wang XM*. Bioactive Self-assembling Peptide Hydrogel Functionalized with BDNF- and NGF- mimicking Peptides Synergistically Promote Peripheral Nerve Regeneration. ACS. Biomater. Sci. Eng. 2018, 4(8): 2994-3005. Yao SL, Yu S, Cao Z, Yang Y, Yu X, Mao H, Wang L, Sun X, Zhao L, Wang XM*. Hierarchically aligned fibrin nanofiber hydrogel accelerated axonal regrowth and locomotor function recovery in rat spinal cord injury. International Journal of Nanomedicine. 2018,13: 2883-2895. Yao SL, Feng XJ, Lu JJ, Zheng YD, Wang XM, Volinsky AA, Wang LN. Antibacterial activity and inflammation inhibition of ZnO nanoparticles embedded TiO2 nanotubes. Nanotechnology. 2018, 29(24): 244003. He YZ, Jin YH, Wang XM, et al. An Antimicrobial Peptide-Loaded Gelatin/Chitosan Nanofibrous Membrane Fabricated by Sequential Layer-by-Layer Electrospinning and Electrospraying Techniques. Nanomaterials. 2018, 8(5): 327. Yan D, Zhao HY, Pei JY, Wang XM. Metal ion-mediated structure and properties of alpha-Fe2O3 nanoparticles. Materials Research Bulletin. 2018, 101: 100-106. Rana D, Wang XM, Webster TJ, Ramalingam M. Biomimetic Nanohydroxyapatite Synthesized With/Without Tris-Buffered Simulated Body Fluid: A Comparative Analysis. Journal of Nanoscience and Nanotechnology. 2018, 18(6): 4423-4427. Liu SC, Lian XJ, w/Wang XM. Silk Nanofibers/Calcium Sulfate Composite: Preparation and Properties on Infective Bone Repair. Chinese Journal of Inorganic Chemistry. 2018, 34(3): 490-498. Li M, Wang Y, Zhang JD, w/Wang XM. Culture of pyramidal neural precursors, neural stem cells, and fibroblasts on various biomaterials. Journal of Biomaterials Science-polymer edition. 2018, 29(17): 2168-2186.

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