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个人简介

教育经历 2001.9-2005.7 四川农业大学林学园艺学院,获学士学位 2005.9-2008.7 中科院沈阳应用生态所,获硕士学位 2008.9-2011.7 中科院成都生物所,获博士学位 工作经历 2011.09-2013.08中科院成都有机化学所开展博士后研究 2013.09-至今 中科院成都生物研究所副研究员

研究领域

不对称有机小分子催化,氮杂环类活性分子的合成与筛选,药物工艺改进等

近期论文

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Min Han, Shi-qi Zhang, Xin Cui, Qi-wei Wang, Guang-xun Li, zhuo tang. Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3 ). Angew. Chem. Int. Ed.[J]. 2022, 61(22): e202201418-, Xiao-kang Nie, Yue Chen, Shi-qi Zhang, Xin Cui, Zhuo Tang, Guang-xun Li. Chiral Primary Amine Catalyzed Enantioselective Tandem Reactions Based on Heyns Rearrangement: Synthesis of α‑Tertiary Amino Ketones. Organic Letters[J]. 2022, 24(10): 2069-2074, Jin Huang, Jin-fang Chen, Xin Cui, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li. Preparation of Dihydronaphthofurans from α‑Hydroxyl Ketones via a One-Pot Multicomponent Reaction Based on Heyns Rearrangement. JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 87(5): 3311-3318, Yang, Gaofeng, Li, Guangxun, Huang, Jin, Fu, Dingqiang, Nie, Xiaokang, Cui, Xin, Zhao, Jinzhong, Tang, Zhuo. Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(7): 5110-5119, http://dx.doi.org/10.1021/acs.joc.0c03064. Huang, Jin, Li, Guangxun, Yang, Gaofeng, Fu, Dingqiang, Nie, Xiaokang, Cui, Xin, Zhao, Jinzhong, Tang, Zhuo. Catalytic asymmetric synthesis of N-substituted tetrahydroquinoxalines via regioselective Heyns rearrangement and stereoselective transfer hydrogenation in one pot. CHEMICAL SCIENCE[J]. 2021, 12(13): 4789-4793, http://dx.doi.org/10.1039/d0sc06264b. Deng, Xiongfei, Tang, Zhuo. An organocatalytic asymmetric Friedel–Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of a-hydroxyl ketones by low loading of chiral phosphoric acid. ChemComm[J]. 2020, 56(16): 2499-2502, Zhang, Shiqi, Li, Guangxun, Li, Ling, Deng, Xiongfei, Zhao, Gang, Cui, Xin, Tang, Zhuo. Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen. ACS CATALYSIS[J]. 2020, 10(1): 245-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000506725100029. Li, Ling, Wang, Yingwei, Zhang, Shiqi, Dong, Xiongfei, Li, Guangxun, Zhao, Gang, Tang, Zhuo. Preparation of Bicyclic Ketal Skeletons with Aldehyde and alpha-Ketone Acid through Cascade Friedel-Crafts Reaction and Stereoselective Acetalization in One Pot. SYNLETT[J]. 2019, 30(18): 2091-2095, Guangxun Li. Chiral Brønsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity. ACS Catalysis. 2019, Li, Lingyu, Zeng, Qingle, Li, Guangxun, Tang, Zhuo. Solvent-Free Synthesis of -Amino Ketones from -Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement. SYNLETT[J]. 2019, 30(6): 694-698, http://210.75.237.14/handle/351003/29660. Liu, Hongxin, Li, Guangxun, Wang, Yingwei, Zhang, Shiqi, Tang, Zhuo. Bioinspired Catalysis: Self-Assembly of a Protein and DNA as a Catalyst for the Aldol Reaction in Aqueous Media. SYNLETT[J]. 2018, 29(5): 560-565, https://www.webofscience.com/wos/woscc/full-record/WOS:000426600100005. Ma, Longjun, Li, Guangxun, Huang, Jin, Zhu, Jin, Tang, Zhuo. Synthesis of asymmetrical thioethers with sulfinamides as the sulfenylation agent under metal-free conditions. TETRAHEDRON LETTERS[J]. 2018, 59(48): 4255-4258, http://dx.doi.org/10.1016/j.tetlet.2018.10.038. Ma, Longjun, Li, Guangxun, Huang, Jin, Zhu, Jin, Tang, Zhuo. Using sulfinamides as high oxidation state sulfur reagent for preparation of sulfenamides. TETRAHEDRON LETTERS[J]. 2018, 59(16): 1600-1603, http://dx.doi.org/10.1016/j.tetlet.2018.03.033. Zhuo Tang. Brønsted-Acid-Catalyzed Substrate-Controlled and Site-Selective Friedel–Crafts Alkylation: A New Strategy for Post-Modification of 1,2-Dihydroquinolines. Asian Journal of Organic Chemistry. 2017, Ren, Xuwen, Li, Guangxun, Huang, Jin, Wang, Weidong, Zhang, Yongpo, Xing, Guomin, Gao, Chunyan, Zhao, Gang, Zhao, Jinzhong, Tang, Zhuo. Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines. ORGANIC LETTERS[J]. 2017, 19(1): 58-61, https://www.webofscience.com/wos/woscc/full-record/WOS:000391781600016. Yang, Guobin, Li, Guangxun, Huang, Jin, Tang, Zhuo, Zhao, Jinzhong. A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2017, 15(48): 10167-10171, https://www.webofscience.com/wos/woscc/full-record/WOS:000418070800007. Li, Guangxun, Tang, Ling, Liu, Hongxin, Wang, Yingwei, Zhao, Gang, Tang, Zhuo. Investigation and Application of Amphoteric alpha-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement. ORGANIC LETTERS[J]. 2016, 18(18): 4526-4529, https://www.webofscience.com/wos/woscc/full-record/WOS:000383640600021. Lai Shujun, Ren Xuwen, Zhao Jinzhong, Tang Zhuo, Li Guangxun. Simple Brønsted acid catalyzed C–H functionalization: efficient access to poly-substituted pyridines. Tetrahedron Letters[J]. 2016, 57(27-28): 2957-2961, http://dx.doi.org/10.1016/j.tetlet.2016.05.061. Li Guangxun, Liu Hongxin, Wang Yingwei, Zhang Shiqi, Lai Shujun, Tang Ling, Zhao Jinzhong, Tang Zhuo. The catalytic enantioselective synthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor.. Chemical communications (Cambridge, England). 2016, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPDF8D2991D7C2990DED7DB229D872F1DDF&DbName=SJPDLAST&DbCode=SJPD&yx=&pr=&URLID=&bsm=.

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