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个人简介

招生专业 071006-神经生物学 招生方向 疾病神经生物学 教育背景 1995-08--2000-01 美国贝勒医学院 药理学和神经科学专业,博士 1992-09--1995-07 中国科学院上海药物所 神经药理学专业,硕士 1987-09--1992-06 华西医科大学 药学专业,学士 工作简历 2015-04~现在, 中国科学院大学, 岗位教授 2014-09~现在, 中国科学院脑科学与智能技术卓越创新中心, 脑疾病部主任 2014-03~现在, 上海科技大学, 特聘教授 2012-05~现在, 中国科学院神经科学研究所, 高级研究员,博士生导师 2003-08~2012-04,中国科学院神经科学研究所, 研究员、博士生导师 2000-03~2003-07,美国杜克大学医学中心James McNamara实验室, 博士后 教授课程 神经生物学 奖励信息 (1) 赛诺菲中国神经科学优秀学者奖, 特等奖, 其他, 2014 (2) 国家百千万人才工程, “有突出贡献中青年专家”, 特等奖, 国家级, 2013 (3) 张香桐基金会青年神经科学家奖, 特等奖, 其他, 2013 (4) 中科院优秀博士论文奖导师奖, 特等奖, 院级, 2013 (5) 国务院特殊津贴, 特等奖, 国家级, 2012 (6) 上海市优秀学术带头人, 特等奖, 市地级, 2012 (7) 国家杰出青年科学基金, 特等奖, 国家级, 2009 (8) 中科院上海分院杰出青年科技创新人才奖, 特等奖, 院级, 2008 (9) 上海市“浦江人才计划”, 特等奖, 市地级, 2006 (10) 中科院“****”, 特等奖, 院级, 2003 科研项目 ( 1 ) 雷特综合症认知功能障碍的分子和神经环路基础, 主持, 国家级, 2014-01--2017-12 ( 2 ) 突触构造的发育与可塑性, 主持, 部委级, 2015-01--2017-07 ( 3 ) 神经元形态发生和功能成熟的分子细胞机制, 参与, 国家级, 2015-01--2019-12 ( 4 ) 大脑皮层和单胺类神经元发育的分子调控网络三期-熊志奇, 参与, 国家级, 2014-01--2016-12 ( 5 ) 囊泡蛋白质机器在神经发育中的作用, 参与, 国家级, 2016-07--2021-06 ( 6 ) 发作性运动障碍分子和环路机制研究, 主持, 部委级, 2016-09--2021-09 参与会议 (1)Molecular mechanism of intellectual disability 2015-11-07 (2)Synaptic and circuit basis of PKD 2015-09-21 (3)Palmitoylation-dependent CDKL5–PSD95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development 2014-11-15 (4)Synaptic function of CDKL5 2014-06-23 (5)Reelin regulates intramembrane proteolysis signaling to control radial migration of cortical neuron. 2014-05-12 (6)Prrt2-deficiency Impairs Presynaptic Plasticity and Voluntary Movements 2014-04-25

研究领域

神经系统疾病是一类发病率较高的疾病,中风、癫痫、早老性痴呆等常见的神经系统疾病影响全球数千万人的健康,加上一些较为罕见的疾病如雷特综合征、Rasmussen脑炎等,已经成为日益严重的医疗负担和社会问题。虽然目前已有一些手段及方法应用于某些神经系统疾病的临床诊断和治疗,但基于发病机制研究的、用于预防或治愈这类神经系统疾病的方案依旧匮乏。本研究组的长期研究方向是了解这些神经系统疾病在细胞和分子水平的发病机理,其中特别关注儿童智力发育障碍疾病和癫痫病的研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

(1) Interactions between N-Ethylmaleimide-Sensitive Factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus., Hippocampus, 2016, 第 4 作者 (2) Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia., J. Neurosci., 2015, 通讯作者 (3) PRRT2 c.649dupC mutation derived from de novo in paroxysmal kinesigenic dyskinesia, CNS Neurosci. Ther., 2013, 第 3 作者 (4) The Angelman Syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons, J. Neurosci., 2013, 通讯作者 (5) Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development, Proc. Natl. Acad. Sci. USA., 2013, 通讯作者 (6) X-linked microtubule-associated protein, Mid1, regulates axon development., Proc. Natl. Acad. Sci. USA., 2013, 通讯作者 (7) Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization, Cell Research, 2012, 通讯作者 (8) Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons, Nature Neuroscience, 2012, 通讯作者 (9) Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone, Cell Research, 2011, 通讯作者 (10) Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model, Cerebral Cortex, 2011, 通讯作者 (11) Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet, Epilepsia, 2011, 通讯作者 (12) Exome sequencing identifies truncating mutations in PRRT2 that casue paroxysmal kinesigenic dyskinesia, Nature Genetics, 2011, 第 3 作者 (13) CDKL5, a protein associated with Rett syndrome, regulates neuronal morphogenesis via Rac1 signaling, J Neurosci., 2010, 通讯作者 (14) NGF-dependent retrograde signaling: survival versus death., Cell Research, 2009, 通讯作者 (15) Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus., J. Neurochem., 2009, 通讯作者 (16) TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons., J. Neurosci., 2009, 通讯作者 (17) Limbic epileptogenesis in a mouse model of fragile X syndrome., Cerebral Cortex, 2009, 通讯作者 (18) Fragile X syndrome and epilepsy., Neurosci. Bull., 2008, 通讯作者 (19) Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse., Neuron, 2008, 第 3 作者 (20) Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth., J. Biol. Chem., 2008, 通讯作者 (21) Brain-derived neurotrophic factor-tropomyosin-related kinase B signaling contributes to activity-dependent changes in synaptic proteins., J. Biol. Chem., 2008, 通讯作者 (22) Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance, Stroke, 2008, 通讯作者 (23) Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis., J. Neurosci., 2007, 通讯作者 (24) Transducer of regulated CREB and late phase long-term synaptic potentiation, FEBS J., 2007, 通讯作者 (25) Requirement of TORC1 for late-phase long-term potentiation in the hippocampus., PLoS ONE, 2006, 通讯作者 (26) Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration., J. Neurosci., 2003, 第 1 作者 (27) Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?, Neuron, 2002, 第 1 作者 (28) Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack., Neuron, 2002, 第 1 作者 (29) Effects of postsynaptic GABAB receptor activation on epileptiform activity in hippocampal slices., Neuropharmacology, 2001, 第 1 作者 (30) Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission., J. Neurophysiol., 2001, 第 1 作者 (31) Regulation of extracellular pH in the developing hippocampus, Dev. Brain Res., 2000, 第 1 作者 (32) Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus, J. Neurophysiol., 2000, 第 1 作者 (33) pH sensitivity of non-synaptic field bursts in the dentate gyrus., J. Neurophysiol., 2000, 第 3 作者 (34) Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression., J. Neurophysiol., 2000, 第 1 作者 (35) Activity-dependent intracellular acidification correlates with the duration of seizure activity., J. Neurosci., 2000, 第 1 作者 (36) Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus, J. Neurophysiol, 1999, 第 1 作者 (37) Astrocytic regulation of the recovery of extracellular potassium after seizures in vivo, Eur. J. Neurosci., 1999, 第 1 作者 (38) Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit, Zhongguo Yao Li Xue Bao, 1998, 第 1 作者 (39) Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus, Epilepsy Res, 1997, 第 1 作者 (40) Effect of –N omega-nitro-L-arginie on working memory of rats in eight-arm maze task, Acta Pharmacologica Sinica, 1995, 第 1 作者 (41) Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment, Acta Pharmacologica Sinica, 1995, 第 1 作者 (42) Effect of huperzine A, a novel acetyl-cholinesterase inhibitor, on radial maze performance in rats, Pharmacol. Biochem. Behav., 1995, 第 1 作者 (43) Huperzine A ameliorates the spatial working memory impairments induced by AF64A, NeuroReport, 1995, 第 1 作者

学术兼职

2016-06-01-今,中国神经科学学会青年组会主任, 2016-06-01-今,中国神经科学学会神经病学基础与临床分会 副主任委员, 2015-10-01-今,中国神经科学学会常务理事, 2015-02-01-今,《Neurogenesis》编委, 2013-07-01-今,《Developmental Neurobiology》编委, 2012-03-01-今,《中国细胞生物学学报》编委,

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