杨有军 - 华东理工大学

个人简介

学习工作经历 2015-现在华东理工大学药学院教授/博导 2010-2015 华东理工大学药学院副教授/博导 2007-2010 德克萨斯大学奥斯汀分校博士后（导师: Eric V. Anslyn教授） 2002-2007 美国路易斯安那州立大学博士（导师: Robert M. Strongin教授） 1997-2002 中国科技大学本科（导师: 王官武教授）学术奖励 2018年自然科学基金委优秀青年基金 2018年 MSMLG2018 Czarnik Emerging Investigator Award 2017年华东理工大学校长奖 2013年上海市科委青年科技启明星 2013年华东理工大学研究生课程优秀任课教师一等奖 2012年华东理工大学药学院优秀青年教师 2012年华东理工大学天鼎东岳奖教金特等奖

研究领域

本课题组以物理有机和有机合成为基础，设计合成具有特殊功能的荧光染料，并进一步开展药学相关研究，具体工作涵盖药化、药理、药剂、药物化学生物学等方面的研究。 1. 染料化学生物学 a) 荧光分子探针的设计开发 b) 生物活性分子的控制释放 2. 染料药物化学 a) 氧化还原疾病的防诊治 b) 临床耐药菌的药物发现

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yansheng Xiao, Yunxia Huang, Zhenhua Zeng, Xiao Luo,*, Xuhong Qian, Youjun Yang.* “Harnessing Thorpe-Ingold Dialkylation to Access High Hill-percentage pH Probes.” Submitted. Yinghua Guo, Xinru Wang, Yan Feng, Xiao Luo, Xiangming Meng*, Xuhong Qian, Youjun Yang.* “Imaging of Lysosomal Oxidative Stress during Autophagy with a Ratiometric Probe Featuring a Large Probe-Product Spectral Separation.” Sens. Actuators B Chem., 2021, Accepted. Yansheng Xiao, Yunxia Huang, Zhenhua Zeng, Xiao Luo*, Xuhong Qian, Youjun Yang.* “Harnessing Thorpe-Ingold Dialkylation to Access High Hill-percentage pH Probes." Sens. Actuators B Chem., 2021, Accepted. Yansheng Xiao, Fang Hu, Xiao Luo*, Mingming Zhao, Zhenglong Sun*, Xuhong Qian*, Youjun Yang.* “Modulating the pKa Values of Hill-Type pH Probes for Biorelevant Acidic pH Range.” ACS Appl. Bio. Mater., 2021, DOI: 10.1021/acsabm.0c01262. Xiu Xuǂ, Meiling Sunǂ, Xiao Luoǂ, Ziqian Zhang, Lin Su, Lingfei Cui, Zhihui Zhu, Xicun Lu, Rui Wang, Feng Han*, Xuhong Qian, Youjun Yang.* “One-Electron Reduction Triggered Nitric Oxide Release for Ischemia-Reperfusion Protection.” Free Radic. Biol. Med., 2021, 164, 13-19. Kai Xin‡, Xinxing Li‡, Yinghua Guo‡, Youhuan Zhong‡, Jungang Wang, Haotian Yang, Jie Zhao, Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo*, Haolu Wang, Xuhong Qian, Wen Yang*, Xiaowen Liang*, Youjun Yang*. “A Mono-Chromophoric Approach to Succinct Ratiometric Fluorescent Probes without Probe-Product Crosstalk.” CCS Chemistry, 2020, 2, 2307–2315. Xiao Luo, Yan Chen, Yanchun Li, Zhenglong Sun*, Weihong Zhu*, Xuhong Qian*, Youjun Yang*, “Structurally-thrifty and visible-absorbing fluorophores.” Spectrochimica Acta Part A, 2021, 245, 118907. Luyan Gu†, Lujia Zhang†, Xiao Luo*, Ying Zheng, Zhiwei Ye, Meng Lv, Jinquan Chen, Chunlai Chen*, Yi Xiao, Weihong Zhu, Xuhong Qian, Youjun Yang*. “The Mechano Donor-Acceptor Coupling (MDAC) Approach for Uni-directional Multi-State Fluorochromism.” Sci China: Chem., 2020, DOI: 10.1007/s11426-020-9874-6. Meng Lv†, Yang Yu†, María E. Sandoval-Salinas†, Jianhua Xu, Zuhai Lei*, David Casanova*, Youjun Yang*, Jinquan Chen*. “Engineering the Charge-Transfer State to Facilitate Spin-Orbit Charge Transfer Intersystem Crossing in Spirobis[anthracene]diones.” Angew. Chem. Int. Ed., 2020, doi.org/10.1002/anie.202009439. Dawei Jiang,‡ Lei Cheng,‡ Yudong Xue, Chao Chen, Chaochao Wang, Guoliang Yang, An Xu,* Youjun Yang,* Yun Gao, Weian Zhang*. “Modulation of the lifespan of C. elegans by the controlled release of nitric oxide.” Chem. Sci., 2020, 11, 8785-8792. Xiao Luo, Youjun Yang*, Xuhong Qian*. “Recent progresses on the development of thioxo-naphthalimides.” Chin. Chem. Lett., 2020, DOI: 10.1016/j.cclet.2020.07.009. Xiao Luo, Luyan Gu, Xuhong Qian, Youjun Yang*. “Molecular probe design via the ‘covalent-assembly’” principle. Chem. Commun., 2020, 56, 9067-9078. P. Rogelio Escamilla#, Yanming Shen#, Quanjuan Zhang, Derek S. Hernandez, Cecil J. Howard, Xuhong Qian, Daria Y. Filonov, Alexander V. Kinev, Jason B. Shear*, Eric V. Anslyn*, Youjun Yang*. “2-Amino-3’-dialkylaminobiphenyl-based Fluorescent Intracellular Probes for Nitric Oxide Surrogate N2O3.” Chem. Sci., 2020,11, 1394-1403 Xiao Luo, Jin Li, Jie Zhao, Luyan Gu, Xuhong Qian*, Youjun Yang*. “A General Approach to the Design of High-Performance Near-Infrared (NIR) D-p-A Type Fluorescent Dyes.” Chin. Chem. Lett., 2019, 30, 839-846. Zuhai Lei, Kai Xin, Shaobing Qiu, Liling Hou, Xiangming Meng*, Youjun Yang*. “A Threshold-Limited Fluorescence Probes for Viscosity.” Front. Chem., 2019, 7, 342. Xiao Luo, Liujia Qian, Yansheng Xiao, Yao Tang, Yang Zhao, Xia Wang, Luyan Gu, Zuhai Lei, Jianming Bao, Jiahui Wu, Tingting He, Fupin Hu, Jing Zheng, Honglin Li, Weiping Zhu, Lei Shao, Xiaojing Dong, Daijie Chen*, Xuhong Qian*, Youjun Yang*. “A Diversity-Oriented Rhodamine Library for Wide-Spectrum Bactericidal Agents with Low Inducible Resistance against Resistant Pathogens.” Nat. Commun., 2019, 10, 258. Shaobing Qiu, Dongdong Dai, Chunlei Guo, Zhenglong Sun, Hui Li, Xuhong Qian*, Youjun Yang*. “Amino-substituted C-coumarins: Synthesis, Spectral Characterizations and Their Applications in Cell Imaging” Dyes Pigments, 2019, 163, 55-61. Shaobing Qiu, Chunlei Guo, Mingkang Wang, Zhenglong Sun, Hui Li, Xuhong Qian* and Youjun Yang*. “Mild Dealkylative N-Nitrosation of N,N-dialkylaniline Derivatives for Convenient Preparation of Photo-Triggered And Photo-Calibrated NO Donors.” Org. Chem. Front., 2018, 5, 3206-3209. Haihong He, Tingting He, Ziqian Zhang, Xiu Xu, Huibin Yang, Xuhong Qian, YoujunYang*. “Ring-restricted N-nitrosated Rhodamine as a Green-ight Triggered, Orange-Emission Calibrated and Fast-Releasing Nitric Oxide Donor.” Chin. Chem. Lett., 2018, 10, 1497-1499. Haihong He, Yuxin Liu, Zhongneng Zhou, Chunlei Guo, Hong-Yin Wang, Zhuang Wang, Xueli Wang, Ziqian Zhang, Fu-Gen Wu, Haolu Wang, Daijie Chen, Dahai Yang, Xiaowen Liang,* Jinquan Chen,* Shengmin Zhou,* Xin Liang,* Xuhong Qian, Youjun Yang.* A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications. Free Radical Biol. Med., 2018, DOI://FRB_FRBM-D-18-00121. Xiao Luo, Haotian Yang, Haolu Wang, Zhiwei Ye, Zhongneng Zhou, Luyan Gu, Jinquan Chen , Yi Xiao, Xiaowen Liang*, Xuhong Qian, and Youjun Yang*. Highly Sensitive Hill-Type Small-Molecule pH Probe That Recognizes the Reversed pH Gradient of Cancer Cells. Anal. Chem., 2018, 90, 5803–5809 Haihong He, Yuxin Liu, Zhongneng Zhou, Yang Xia, Yingxue Qi, Zhuang Wang, Hong-Yin Wang, Xueli Wang, Jianming Bao, Ziqian Zhang, Fu-Gen Wu, Haolu Wang, Daijie Chen, Dahai Yang, Xiaowen Liang,* Jinquan Chen,* Shengmin Zhou,* Xin Liang,* Xuhong Qian, Youjun Yang.* “Water-soluble, Green-light Triggered and Photo-Calibrated Nitric Oxide Donors for Biological Applications.” Bioconjugate Chem., 2018, 29, 1194-1198. Haihong He, Zhiwei Ye, Ying Zheng, Xiu Xu, Chunlei Guo, Yi Xiao,* Wei Yang,* Xuhong Qian,* and Youjun Yang*. “Super-Resolution Imaging of Lysosomes with a Nitroso-Caged Rhodamine.” Chem. Commum., 2018, 54, 2842-2845. Haihong He, Zhiwei Ye, Yi Xiao,* Wei Yang,* Xuhong Qian,* Youjun Yang*. “Super-Resolution Monitoring of Mitochondrial Dynamics upon Time-Gated Photo-Triggered Release of Nitric Oxide.” Anal. Chem., 2018, 90, 2164-2169. Zuhai Lei, Zhenhua Zeng, Xuhong Qian, Youjun Yang*. “A novel chromogenic and fluorogenic scaffold for detection of oxidative radicals.” Chin. Chem. Lett., 2017, 28, 2001-2004. Zuhai Lei, Ping Yue, Xueli Wang, Xinran Li, Yi Li, Haihong He, Xiao Luo, Xiangming Meng*, Jinquan Chen*, Xuhong Qian*, Youjun Yang*. “TPZ, a bright centrosymmetric two-photon scaffold for bioimaging.” Chem. Commun., 2017, 53, 10938-10941. Zuhai Lei, Xinran Li, Xiao Luo, Haihong He, Jing Zheng, Xuhong Qian, Youjun Yang*. “Bright, Stable and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region.” Angew. Chem. Int. Ed., 2017, 56, 2979-2983. Highlighted by Sci. Transl. Med, DOI: 10.1126/scitranslmed.aam6065. Ziqian Zhang, Yi Li, Haihong He, Xuhong Qian, Youjun Yang*. “Mild Chemo-Triggered Genetration of a Fluorophore-Tethered Diazoalkane Species via Smiles Rearrangement.” Org. Lett., 2016, 18, 4674-4677. Ziqian Zhang, Jiayao Wu, Zhihao Shang, Chao Wang, Jiagao Cheng, Xuhong Qian, Yi Xiao*, Zhiping Xu*, Youjun Yang.* “Photo-Calibrated NO release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation.” Anal. Chem., 2016, 88, 7274-7280. Quanjuan Zhang, Na Zhang, Yi-Tao Long, Xuhong Qian, Youjun Yang*. “Understanding the Selectivity of a Multi-Channel Fluorescent Probe for Peroxynitrite Over Hypochlorite.” Bioconjugate Chem., 2016, 27, 341-353. Zuhai, Lei; Xinran Li; Yi Li; Xiao Luo; Miaomiao Zhou; Youjun Yang*. “Synthesis of Sterically Protected Xanthene Dyes with Bulky Groups at C-3’ and C-7’.” J. Org. Chem., 2015, 80, 11538-11543. Yanming Shen, Zhihao Shang, Yanhong Yang, Shaojia Zhu, Xuhong Qian, Ping Shi*, Jing Zheng*, and Youjun Yang*. “Structurally Rigid 9-Amino-benzo[c]cinnoliniums Make Up a Class of Compact and Large Stokes-Shift Fluorescent Dyes for Cell-Based Imaging Applications.” J. Org. Chem., 2015, 80, 5906−5911. Yanming Shen, Quanjuan Zhang, Xuhong Qian, and Youjun Yang*. “Practical Assay for Nitrite and Nitrosothiol as an Alternative to the Griess Assay or the 2,3-Diaminonaphthalene Assay.” Anal. Chem., 2015, 87, 1274-1280. Ziqian Zhang, Baoyan Zhang, Xuhong Qian, Zhong Li, Zhiping Xu*, Youjun Yang*. Simultaneous Quantification of Hg2+ and MeHg+ in Aqueous Media by a Single Fluorescent Probe via Multiplexing in the Time Domain. Anal. Chem., 2014, 86, 11919-11924. Linlin Song, Zuhai Lei, Baoyan Zhang, Zhiping Xu*, Zhong Li* and Youjun Yang*. “A Zero-Background Fluorescent Probe for Hg2+ Designed via the Covalent-Assembly Principle.” Anal. Methods, 2014, 6, 7597-7600. Zuhai Lei, Youjun Yang*. A concise colorimetric and fluorimetric probe for Sarin related threats designed via the covalent-assembly approach. J. Am. Chem. Soc., 2014, 136, 6594−6597. Highlight in Advances in Engineering. Quanjuan Zhang, Zhichuan Zhu, Yongli Zheng, Jiagao Cheng, Na Zhang, Yi-Tao Long, Jing Zheng, Xuhong Qian, and Youjun Yang*. “A Three-Channel Fluorescent Probe That Distinguishes Peroxynitrite from Hypochlorite.” J. Am. Chem. Soc., 2012, 134, 18479-18482.