杨有军 - 华东理工大学

个人简介

学习工作经历 2015-现在华东理工大学药学院教授/博导 2010-2015 华东理工大学药学院副教授/博导 2007-2010 德克萨斯大学奥斯汀分校博士后（导师: Eric V. Anslyn教授） 2002-2007 美国路易斯安那州立大学博士（导师: Robert M. Strongin教授） 1997-2002 中国科技大学本科（导师: 王官武教授）学术奖励 2018年自然科学基金委优秀青年基金 2022年上海市科委青年学术带头人 2022年华东理工大学东岳奖教金特等奖 2018年 MSMLG2018 Czarnik Emerging Investigator Award 2017年华东理工大学青年英才校长奖 2013年上海市科委青年科技启明星 2013年华东理工大学研究生课程优秀任课教师一等奖 2012年华东理工大学药学院优秀青年教师 2012年华东理工大学天鼎东岳奖教金特等奖

研究领域

1. 荧光分子探针的设计开发 2. 手术导航染料的设计开发 3. 气体信号分子的控制释放 4. 氧化还原稳态的精准调控 5. 抗耐药菌先导的设计开发

近期论文

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Xinru Hu, Yan Dong, Yuyang Zhang, Xiaohua Chen, Chuanbao Yuan, Danyang Wang, Prof. Xuhong Qian, Xiao Luo, Youjun Yang. Optimization of the Structural Rigidity of a Deep-NIR Scaffold for Bioimaging. Chemphotochem 2024, 8, e202400156. Xiaodong Zhang, Ming Liu, Yingqi Hu, Xueli Wang, Ruwei Wei, Cheng Yao, Cunjian Shi, Yangting Qiu, Tao Yang, Xiao Luo, Jinquan Chen*, Wen Sun*, Huabing Chen*, Xuhong Qian*, Youjun Yang*. Albumin-Chaperoned Deep-NIR Triarylmethane Dyes for High-Contrast In Vivo Imaging and Photothermal Therapy. Adv. Mater., 2024, 10.1002/adma.202411515. Cheng Yao, Ruwei Wei, Jie Zhou, Xiaodong Zhang, Xicun Lu, Yan Dong, Ruofan Chu, Yuxin Sun, Yu Wang, Wencheng Xia, Dahui Qu, Cong Liu, Jun Ren, Guangbo Ge, Jinquan Chen, Xuhong Qian, Xiao Luo, Youjun Yang*. A Stable, Biocompatible SWIR Nanoribbon for Dual-channel in vivo Imaging. Nat. Commun., 2024, 10.1038/s41467-024-55445-x. Xiaohua Chen, Jiamin Liu, Ming Chen, Jie Zhou, Yuyang Zhang, Xinru Hu, Weixi Geng, Qiyue Mao, Hiroaki Kitagishi, Jinquan Chen, Xuhong Qian,* Youjun Yang,* Yuan Lei,* Xiao Luo*. Green-Light-Triggered and Self-Calibrated Cascade Release of Nitric Oxide and Carbon Monoxide for Synergistic Glaucoma Therapy. J. Am. Chem. Soc., 2024, 146, 30361-30371. Lei Yin, Bei Zhao, Jie Zhou, Yunxia Huang, Hao Ma, Ting Zhou, Jie Mou, Peiru Min*, Jinquan Chen*, Guangbo Ge*, Xuhong Qian*, Xiao Luo*, Youjun Yang*. A Carbon-Caged Rhodamine Generating Nitrosoperoxycarbonate for Photoimmunotherapy. Angew. Chem. Int. Ed., 2024, 63, e202402949. Xicun Lu, Lei Yin, Xiaoli Zhuang, Ruwei Wei, Cheng Yao, Yuyang Zhang, Yuze Wang, Xiao Luo, Xuhong Qian, Youjun Yang*. Highly Photostable Deep-NIR Chromophore with a Superior Molar Absorptivity for Efficient Photothermal Therapy. Ind. Eng. Chem. Res., 2024, 63, 1239-1247. Xicun Lu, Xiaoli Zhuang, Yan Dong, Chong Chen, Ruwei Wei, Weichao Chen, Hui Li, Xiao Luo, Xuhong Qian, and Youjun Yang*. Super-Photostability and Super-Brightness of EC5 Dyes for Super-Resolution Microscopy in the Deep Near-Infrared Spectral Region. Chem. Mater., 2024, 36, 949–958. Ruwei Wei, Yan Dong, Xueli Wang, Jin Li, Zuhai Lei, Zhubin Hu, Jinquan Chen, Haitao Sun, Hao Chen, Xiao Luo, Xuhong Qian, Youjun Yang. Rigid and Photostable Shortwave Infrared Fluorophore (EC7) Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging. J. Am. Chem. Soc., 2023, 145, 12013–12022. Jin Li, Ruwei Wei, Xiaodong Zhang, Xiao Luo, Xuhong Qian, Youjun Yang*. A Practical Synthesis of Near-infrared Benzannulated Xanthenoid Dyes.Synlett 2023, accepted. Yan Dong, Ye Zou, Xiaotong Jia, Lei Yin, Weiwei He, Xiao Luo, Xuhong Qian, Youjun Yang*. An acidic medium-compatible deep-near-infrared dye for in vivo imaging. Smart Molecules, 2023, e20230001. Yinghua Guo, Lei Yin, Xuhong Qian, Youjun Yang, Xiao Luo*. PET/d-PET (PdP) Pairing for the Design of Dual-Channel Probes. Anal. Chem., 2023, 95, 9722–9728. Yan Dong, Xicun Lu, Yi Li, Weichao Chen, Lei Yin, Jie Zhao, Xinru Hu, Xinran Li, Zuhai Lei, Yuyang Wu, Hao Chen, Xiao Luo, Xuhong Qian, Youjun Yang*. Spectral and biodistributional engineering of deep near-infrared chromophore. Chin. Chem. Lett., 2023, 34, 108154. Hui Bian, Dandan Ma, Fei Pan, Xiaodong Zhang, Kai Xin, Xinfu Zhang, Youjun Yang*, Xiaojun Peng*, and Yi Xiao*. Cardiolipin-Targeted NIR-II Fluorophore Causes “Avalanche Effects” for Re-Engaging Cancer Apoptosis and Inhibiting Metastasis. J. Am. Chem. Soc. 2022, 144, 22562–22573. Jin Li, Yan Dong, Ruwei Wei, Guanyu Jiang, Cheng Yao, Meng Lv, Yuyang Wu, Sarah H. Gardner, Feng Zhang, Melissa Y. Lucero, Jian Huang, Hao Chen, Guangbo Ge, Jefferson Chan, Jinquan Chen, Haitao Sun, Xiao Luo, Xuhong Qian, and Youjun Yang*. Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging. J. Am. Chem. Soc. 2022, 144, 14351–14362. Linfeng Xing†, Bin Wang†, Jin Li†, Xinjian Guo, Xicun Lu, Xiaohua Chen, Haitao Sun, Zhenrong Sun, Xiao Luo*, Suhua Qi*, Xuhong Qian*, Youjun Yang*. “A Fluorogenic ONOO--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage.” J. Am. Chem. Soc., 2022, 144, 2114-2119. Yansheng Xiao, Yunxia Huang, Zhenhua Zeng, Xiao Luo*, Xuhong Qian, Youjun Yang*. “Harnessing Thorpe–Ingold Dialkylation to Access High-Hill-Percentage pH Probes.” J. Org. Chem., 2021, 87, 85-93. 20211227. Meng Lv+, Xicun Lu+, Yanrong Jiang, Mara E. Sandoval-Salinas, David Casanova*, Haitao Sun, Zhenrong Sun, Jianhua Xu, Youjun Yang*, Jinquan Chen* “Near-Unity Triplet Generation Promoted via Spiro-Conjugation.” Angew. Chem. Int. Ed., 2022, doi.org/10.1002/anie.202113190. Hui Bian, Dandan Ma, Xinfu Zhang*, Kai Xin, Youjun Yang*, Xiaojun Peng*, Yi Xiao*. Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep-Seated Tumors.Small 2021, 17, 2100398. Ying Zheng#, Zhiwei Ye#, *, Zengjin Liu*, Wei Yang, Xinfu Zhang, Youjun Yang*, Yi Xiao*. Nitroso-Caged Rhodamine: “A Superior Green Light-Activatable Fluorophore for Single-Molecule Localization Super-Resolution Imaging.” Anal. Chem., 2021, 93, 7833-7842. Yang Yu, Xiaodong Zhang, Yan Dong, Xiao Luo*, Xuhong Qian, Youjun Yang*. Fusing the Nagano’s and the Anslyn’s chemistry for lyso-specifc NO detection.Sens. Actuators B Chem.,2021, 346, 130562. Xiaodong Zhang, Mengmeng Zhang, Yu Yan, Mingkang Wang, Jin Li, Yang Yu, Yi Xiao*, Xiao Luo, Xuhong Qian, Youjun Yang*. “Dihydro-Si-Rhodamine for Live-Cell Localization Microscopy.” Chem. Commun.,2021. 57, 7553-7556. 20210701. Fang Hu, Yunxia Huang, Yansheng Xiao, Yanchun Li, Xiao Luo*, Xuhong Qian, Youjun Yang*. “A dual-channel Hill-type small-molecule pH probe.” Anal. Methods. 2021, 13, 3012–3016. Yinghua Guo, Xinru Wang, Yan Feng, Xiao Luo, Xiangming Meng*, Xuhong Qian, Youjun Yang.* “Imaging of Lysosomal Oxidative Stress during Autophagy with a Ratiometric Probe Featuring a Large Probe-Product Spectral Separation.” Sens. Actuators B Chem., 2021, 335, 129713. Yansheng Xiao, Yunxia Huang, Zhenhua Zeng, Xiao Luo*, Xuhong Qian, Youjun Yang.* “Harnessing Thorpe-Ingold Dialkylation to Access High Hill-percentage pH Probes." Sens. Actuators B Chem., 2021, 335, 129712. Yansheng Xiao, Fang Hu, Xiao Luo*, Mingming Zhao, Zhenglong Sun*, Xuhong Qian*, Youjun Yang.* “Modulating the pKa Values of Hill-Type pH Probes for Biorelevant Acidic pH Range.” ACS Appl. Bio. Mater., 2021, 4, 2097-2103. Xiu Xuǂ, Meiling Sunǂ, Xiao Luoǂ, Ziqian Zhang, Lin Su, Lingfei Cui, Zhihui Zhu, Xicun Lu, Rui Wang, Feng Han*, Xuhong Qian, Youjun Yang.* “One-Electron Reduction Triggered Nitric Oxide Release for Ischemia-Reperfusion Protection.” Free Radic. Biol. Med., 2021, 164, 13-19. Ziqian Zhang, Xiao Luo, Youjun Yang*. “From Spontaneous to Photo-triggered and Photo-calibrated Nitric Oxide Donors”. Isr. J. Chem., 2020, 61, 159-168. Kai Xin‡, Xinxing Li‡, Yinghua Guo‡, Youhuan Zhong‡, Jungang Wang, Haotian Yang, Jie Zhao, Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo*, Haolu Wang, Xuhong Qian, Wen Yang*, Xiaowen Liang*, Youjun Yang*. “A Mono-Chromophoric Approach to Succinct Ratiometric Fluorescent Probes without Probe-Product Crosstalk.” CCS Chemistry, 2020, 2, 2307–2315. Xiao Luo, Yan Chen, Yanchun Li, Zhenglong Sun*, Weihong Zhu*, Xuhong Qian*, Youjun Yang*, “Structurally-thrifty and visible-absorbing fluorophores.” Spectrochimica Acta Part A, 2021, 245, 118907. Luyan Gu†, Lujia Zhang†, Xiao Luo*, Ying Zheng, Zhiwei Ye, Meng Lv, Jinquan Chen, Chunlai Chen*, Yi Xiao, Weihong Zhu, Xuhong Qian, Youjun Yang*. “The Mechano Donor-Acceptor Coupling (MDAC) Approach for Uni-directional Multi-State Fluorochromism.” Sci China: Chem., 2020, DOI: 10.1007/s11426-020-9874-6. Meng Lv†, Yang Yu†, María E. Sandoval-Salinas†, Jianhua Xu, Zuhai Lei*, David Casanova*, Youjun Yang*, Jinquan Chen*. “Engineering the Charge-Transfer State to Facilitate Spin-Orbit Charge Transfer Intersystem Crossing in Spirobis[anthracene]diones.” Angew. Chem. Int. Ed., 2020, doi.org/10.1002/anie.202009439. Dawei Jiang,‡ Lei Cheng,‡ Yudong Xue, Chao Chen, Chaochao Wang, Guoliang Yang, An Xu,* Youjun Yang,* Yun Gao, Weian Zhang*. “Modulation of the lifespan of C. elegans by the controlled release of nitric oxide.” Chem. Sci., 2020, 11, 8785-8792. Xiao Luo, Youjun Yang*, Xuhong Qian*. “Recent progresses on the development of thioxo-naphthalimides.” Chin. Chem. Lett., 2020, DOI: 10.1016/j.cclet.2020.07.009. Xiao Luo, Luyan Gu, Xuhong Qian, Youjun Yang*. “Molecular probe design via the ‘covalent-assembly’” principle. Chem. Commun., 2020, 56, 9067-9078. P. Rogelio Escamilla#, Yanming Shen#, Quanjuan Zhang, Derek S. Hernandez, Cecil J. Howard, Xuhong Qian, Daria Y. Filonov, Alexander V. Kinev, Jason B. Shear*, Eric V. Anslyn*, Youjun Yang*. “2-Amino-3’-dialkylaminobiphenyl-based Fluorescent Intracellular Probes for Nitric Oxide Surrogate N2O3.” Chem. Sci., 2020,11, 1394-1403