个人简介

上海市化学生物学重点实验室主任、药物化工研究所所长

研究领域

主要从事绿色农药创制研究

1）昆虫行为调控剂的分子设计、合成及作用机制研究 主要包含：昆虫生长调节剂、昆虫飞行调控剂、新烟碱杀虫剂等绿色农药的创制研究； 2）含硒化合物的设计合成及生物性能研究 主要包含：含硒除草剂、含硒植物生长调节剂的创制及生物性能研究

近期论文

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Yin Xu, Fukai Wang, Jilin Li, Xusheng Shao, Xiaoyong, Xu, Zhong Li*. Synthesis of novel imidazopyrrolo-fused isoxazole derivatives through acid-mediated intramolecular 1,3-dipolar cycloaddition. Synlett 2016, 27, 1397-1402 Hui Zeng, Pengtao Yuan, Fukai Wang, Xiaoyong Xu, Xusheng Shao, Zhong Li*. A novel and selective synthetic approach for the access of pyrrolo[1,2-a] imidazol-7-one or pyrrol-3-one. Tetrahedron Lett. 2016, 57, 4031–4035 Haibo Bao, Xusheng Shao, Yixi Zhang, Yayun Deng, Xiaoyong Xu, Zewen Liu, Zhong Li*. Specific Synergist for Neonicotinoid Insecticides: IPPA08, a cis-Neonicotinoid Compound with a Unique Oxabridged Substructure. J. Agric. Food Chem. 2016, 64, 5148–5155. Li Han, Yian Feng, Ming Luo, Zihao Yuan, Xusheng Shao, Xiaoyong Xu, Zhong Li*, 2,2,2-Trifluoroethanol activated one-pot Mannich-like reaction of b-nitroenamines, secondary amines, and aromatic aldehydes. Tetrahedron Lett. 2016, 57, 2727–2731. Ye Liu, Chao Lei, Xiaoyong Xu, Xusheng Shao, Zhong Li*. Design, synthesis and insecticidal activity of biphenyl-diamide derivatives, Chin. Chem. Lett. 2016, 27, 321-324. Jiling Li, Dang Wu, Xiaoyong Xu, Jin Huang, Xusheng Shao and Zhong Li*. Design, synthesis and inhibitory activity against human dihydroorotate dehydrogenase (hDHODH) of 1, 3-benzoazole derivatives bearing amide units. Bioorg. Med. Chem. Lett. 2016, 26, 3064-3066. Yefeng Fan, Wenwen Zhang, Xusheng Shao, Zhiping Xu, Xiaoyong Xu, Zhong Li*. Facile three-component synthesis and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine derivatives. Chin. Chem. Lett. 2015, 26 : 1-5. Yefeng Fan, Song Liu, Nanyang Chen, Xusheng Shao, Xiaoyong Xu, Zhong Li*. Oxidation Strategy for the Synthesis of Regioisomeric Spiroisobenzofuranopyrroles: Facile Entries to Spiro[isobenzofuran-1,2′-pyrrole] and Spiro[isobenzofuran-1,3′-pyrrole] Derivatives. Synlett. 2015, 26, 393-403. Yanpeng Lou, Gang Zhao*, Zhong Li*. Enantioselective direct mannich reactions of cyclic β-ketoesters catalyzed by chiral phosphine via a novel dual-reagent catalysis. Org. Lett. 2015, 17, 688-691. Baoyan Zhang, Zhiping Xu*, Yixi Zhang, Xusheng Shao, Xiaoyong Xu, Jiagao Cheng, Zhong Li*. Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells. Pestic. Biochem. Physiol. 2015, 119, 81-89. Xuanqi Liu, Xiaoyong Xu, Chao Li, Hanxue Zhang, Qiuguo Fu, Xusheng Shao, Qingfu Ye*, Zhong Li*. Degradation of chiral neonicotinoid insecticide cycloxaprid in flooded and anoxic soil. Chemosphere, 2015, 119, 334-341. Xuanqi Liu, Xiaoyong Xu, Qingfu Ye*, Zhong Li*. Bioavailability and release of nonextractable (bound) residues of chiral cycloxaprid using geophagous earthworm metaphire guillelmi in rice paddy soil. Sci. Total Environ. 2015, 526: 243-250. Xuanqi Liu, Xiaoyong Xu, Chao Li, Hanxue Zhang, Qiuguo Fu, Xusheng Shao, Qingfu Ye*, Zhong Li*. Assessment of the Enviromental Fate of Cycloxaprid in Flooded and Anaerobic Soils by Radioisotopic Tracing. Sci. Total Environ.. 2016, 543: 116-122. Renbo Xu, Rui Xia, Ming Luo, Xiaoyong Xu*, Jiagao Cheng, Xusheng Shao, Zhong Li*. Design, Synthesis, Crystal Structures, and Insecticidal Activities of Eight-Membered Azabridge Neonicotinoid Analogues. J. Agric. Food Chem., 2014, 62(2), 381–390