个人简介

1998-present, William Greenleaf Eliot Professor of Chemistry, Washington University, St. Louis, MO 1995-present, Prof. of Radiology, Washington University, School of Medicine, St. Louis, MO. 1992-present, Res. Prof. of Chemistry in Medicine, Washington University School of Medicine, St. Louis, MO. 1988-2010, Chairman & Professor of Chemistry, Washington University, St. Louis, MO. 1986-1992, Res. Assoc. Prof. of Chem. in Medicine, Washington Univ. School of Medicine, St. Louis, MO. 1985-1988, Associate Professor of Chemistry, Washington University, St. Louis, MO. 1980-1986, Res. Asst. Prof. of Chemistry in Medicine, Washington Univ. School of Medicine, St. Louis, MO. 1979-1985, Assistant Professor of Chemistry, Washington University, St. Louis, MO. 1978-1979, NIH Postdoctoral Fellow, Dept. of Biochemistry, University of Oxford, Oxford, England.

研究领域

Biological Chemistry/Biophysical Chemistry/Biophysics/Cancer/Cells/In Vivo Magnetic Resonance/Living Systems/Magnetic Resonance Imaging/Magnetic Resonance/Neuroscience/Physical Chemistry Plants/Small-Animal Models/

Magnetic Resonance of Intact Biological Systems: Ackerman and collaborators within the Biomedical MR Laboratory (BMRL) are focused on the development and application of magnetic resonance spectroscopy (MRS) and imaging (MRI) for study of intact, functioning biological systems representing both Animalia and Plantae Kingdoms. Cell/tissue function and structure are accessible via MR methods, advantages of which include: ● non-ionizing radiation (MR techniques are inherently non-invasive and non-destructive); ●simultaneous, multi-component metabolic analysis; and ● sensitivity to subtle changes in motion/displacement, magnetic susceptibility, and structure at the molecular, micro-, and mesocopic levels. Two projects serve to illustrate this theme.

近期论文

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J.J.H. Ackerman and J.J. Neil, "The Use of MR-detectable Reporter Molecules and Ions to Evaluate Diffusion in Normal and Ischemic Brain", NMR Biomed., 23: 725-733 (2010). J.J.H. Ackerman and J.J. Neil, "Biophysics of Diffusion in Cells" in Diffusion MRI: Theory, Methods and Applications (D Jones, ed.), Ch 8, Pgs 110-124, Oxford U. Press, Oxford, 2010. J.R. Anderson, Q. Ye, J.J.Neil, J.J.H. Ackerman, and J.R. Garbow, "Diffusion Effects on Longitudinal Relaxation in Poorly Mixed Compartments", J. Magn. Reson., 211: 30-36 (2011). W.M. Spees, N. Buhl, P. Sun, J.J.H. Ackerman, J.J. Neil, and J.R. Garbow, "Quantification and Compensation of Eddy Current-Induced Magnetic Field Gradients", J. Magn. Reson., 212: 116-123 (2011). W.M. Spees, S.-K. Song, J.R. Garbow, J.J. Neil, and J.J.H. Ackerman, "The Use of Ethylene Glycol to Evaluate Gradient Performance in Gradient-Intensive Diffusion MR Sequences", Magn. Reson. Med., 68: 319-324 (2012). X. Ge, D.A. d'Avignon, J.J.H. Ackerman, A. Collavo, M. Sattin, E.L. Ostrander, E.L. Hall, R.D. Sammons, and C. Preston, "Vacuolar Glyphosate-Sequestration Correlates with Glyphosate Resistance in Ryegrass (Lolium spp.) from Australia, South America and Europe: a 31P-NMR Investigation", J. Agric. Food Chem., 60: 1243-1250 (2012).