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基于新技术、新方法和新反应的新型杂环化合物的设计合成,构建具有生物活性的类天然小分子化合物用于创新药物研究。

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Zheng Wang,[+] Xingxin Yu*[+], Bo-Xue Tian, Daniel T. Payne, Wu-Lin Yang, Yang-Zi Liu, John S. Fossey, Wei-Ping Deng*. ([+] equal contribution) Chem. Eur. J., 2015, 21, 10457-10465.Chiral N,O-Ligand/Cu(OAc)2 Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivatives via 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-phthalimidoacrylates. Wu-Lin Yang, Yang-Zi Liu, Shuai Luo, Xingxin Yu*, John S. Fossey, Wei-Ping Deng*. Chem. Commun., 2015, 51, 9212-9215. (Highlighted by Synfacts, 2015, 11, 738.)The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides. Fei-Fei Tang, Wu-Lin Yang, Xingxin Yu*, Wei-Ping Deng*. Catal. Sci. Technol., 2015, 5, 3568-3575.Cu(OAc)2/FOXAP complex catalyzed construction of 2,5-dihydropyrrole derivatives via asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethynyl ketones. Shan-Shan Jiang, Qin-Chang Xu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. J. Org. Chem., 2015, 80, 3159-3169.Kinetic Resolution of α-Methylene-β-hydroxy Esters Catalyzed by Acyl Transfer Catalyst An-PIQ. Shan-Shan Jiang, Bo-Qi Gu, Ming-Yu Zhu, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1187-1191.Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ. Wen-Jing Qin, Yi Li, Xingxin Yu*, Wei-Ping Deng*. Tetrahedron, 2015, 71, 1182-1186.TBAI/TBHP catalyzed direct N-acylation of sulfoximines with aldehydes. Jiang Meng, Di Wu, Ying Shi, Xingxin Yu*, Wei-Ping Deng. Tetrahedron, 2015, 71, 1074-1079.Construction of 1H-pyrrol-2-ylphosphonates via [3+2] cycloaddition of phosphate azomethine ylides with ynones. Xianbo Wang, Xingxin Yu*. J. Org. Chem., 2014, 79, 7854-7860.Silver(I) and Copper(I) Co-catalyzed Tandem Reaction of 2-Alkynylbenzaldoximes with Aldehydes or Alcohols: Approach to 4-Carboxylated Isoquinolines. Shanshan Jiang, Bin Hu, Xingxin Yu*, Weiping Deng*. Chin. J. Chem., 2014, 32, 694-698.Fc-PIP Catalyzed Asymmetric Synthesis of cis-2,3-Dihydrobenzofurans. Yong Luo, Xiaolin Pan, Xingxin Yu*, Jie Wu*. Chem. Soc. Rev., 2014, 43, 834-846.Double Carbometallation of Alkynes: An Efficient Strategy for the Construction of Polycycles.

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