聂宗秀 - 中国科学院化学研究所 -

个人简介

2009研究员中科院化学所 2003博士中科院武汉物数所 2004-2005讲师武汉大学物理系 2005-2007博后台湾中研院原分所 2007-2008博后美国普度大学 2016年国家杰出青年基金获得者

研究领域

1.生物颗粒（包括细胞、细菌和病毒）质谱分析。 2.离子阱便携式质谱仪研制及质谱理论研究。 3.活体质谱在线分析。 4.基质辅助激光解吸电离-飞行时间质谱（MALDI-TOF）小分子质谱分析。

近期论文

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论文著作 92.J.Han,X.Huang,H.H.Liu,C.Q.Xiong*,andZ.X.Nie*,LaserCleavableProbeforin-SituMultiplexedGlycanDetectionbySingleCellMassSpectrometry,Chem.Sci.,2019,10,10958-10962. 91.C.Q.Xiong,H.H.Liu,C.Z.Liu,J.J.Xue,L.P.Zhan,andZ.X.Nie*,Mass,sizeanddensitymeasurementofmicroparticlesinaQuadrupoleiontrap,Anal.Chem.,2019,91,13508-13513. 90.Y.M.Jiang,J.Sun,Y.Cui,L.P.Zhan,P.Q.Luo,X.Huang,X.Y.Zhang,Y.R.Jiang*,andZ.X.Nie*,Ti3C2MXeneasadual-modesubstrateprovidesrapiddifferentiationandquantitationofglycanisomersusingLDI-MS,Chem.Comm.,2019,2019,55,10619-10622. 89.X.Huang,J.L.Jiang,Y.M.Zhang,L.P.Zhang,C.Z.Liu,C.Q.Xiong,andZ.X.Nie*,Aminiatureparticlemassspectrometer,Anal.Chem.,2019,91,9393-9397. 88.Y.F.Li,P.Q.Lou,X.H.Cao,J.N.Wang,J.Y.Wang,L.P.Zhan,andZ.X.Nie*,EnhancingSurface-AssistedLaserDesorptionIonizationMassSpectrometryPerformancebyIntegratingPlasmonicHot-ElectronTransferEffectthroughSurfaceModification,Chem.Comm.,2019,55,5769-5772. 87.L.L.Qu,Y.M.Jiang,X.Y.Huang,M.Cui,F.J.Ning,T.Liu,Y.Y.Gao,D.Wu,Z.X.Nie*,andL.P.Lou*,High-throughputMonitoringofMulticlassSyrupAdulterantsinHoneyBasedontheOligosaccharideandPolysaccharideProfilesbyMALDIMassSpectrometry.J.Agric.FoodChem.2019,67,11256-11261. 86.L.Zhu,J.Han,Z.H.Wang*,L.H.Yin,W.Zhang,Y.Peng,andZ.X.Nie*,CompetitiveAdsorptiononGoldNanoparticleforHumanPapillomavirus16L1ProteinDetectionbyLDI-MS,Analyst,2019,144,6641-6646. 85.Y.M.Jiang,J.Sun,X.Huang,H.X.Shi,C.Q.Xiong,andZ.X.Nie,DirectidentificationofforensicbodyfluidsbyMALDI-MS,Analyst,2019,144,7017-7023. 84.S.H.Yan,L.P.Zhan,C.Z.Liu,L.Fu,R.Chen*,andZ.X.Nie,MassspectrometryimagingofsmallmoleculeinsituinLepidiummeyenii(Maca)usinggoldnanoparticlesmatrix,MicrochemicalJ.,2019,150,1040190. 83.J.M.Xu,Z.L.Zhang,R.Z.Liu,Y.Sun,H.H.Liu,Z.X.Nie,X.Zhao,X.P.Pu,FunctionofcomplementfactorHandimagingofsmallmoleculesbyMALDIMSIinamethamphetaminebehavioralsensitizationmodel,BehaviouralBrainResearch,2019,364,233-244. 82.J.J.Xue,H.H.Liu,S.M.Chen*,C.Q.Xiong*,L.P.Zhan,J.Sun,andZ.X.Nie*,Massspectrometryimagingoftheinsitudrugreleasefromnanocarriers,ScienceAdvances,2018,4,eaat9039. 81.L.Zhu,L.H.Yin,J.J.Xue,Z.H.Wang*,andZ.X.Nie*,MassSpectrometryGenotypingofHumanPapillomavirusbasedonNanoMaterialsHigh-EfficiencySelectiveEnrichment,ACSAppl.Mater.Interfaces,2018,10,41178-41184. 80.J.L.Liu,W.Tang,X.Z.Meng,L.P.Zhan,W.Xu*,Z.X.Nie*,andZ.L.Wang*,ImprovingthePerformanceofMini2000MassSpectrometerwithATriboelectricNanogeneratorsElectrosprayIonizationSource,ACSOmega,2018,3,12229-12234. 79.Y.F.Li,X.H.Cao,L.P.Zhan,J.J.Xue,J.Y.Wang,C.Q.Xiong,andZ.X.Nie*,HotElectronTransferPromotesIonProductioninPlasmonicMetalNanostructureAssistedLaserDesorptionIonizationMassSpectrometry,Chem.Comm.2018,54,10905-10908. 78.L.P.Zhan,Y.Liu,X.B.Xie,C.Q.Xiong,andZ.X.Nie*,Heat-inducedRearrangementofDisulfideBondofLactoglobulinCharacterizedbyMultiplyChargedMALDI-TOF/TOFMassSpectrometry,Anal.Chem.2018,90,10670-10675. 77.J.Han,Y.F.Li,L.P.Zhan,J.J.Xue,J.Sun,C.Q.Xiong*,andZ.X.Nie*,ANovelMassSpectrometryMethodBasedonCompetitiveNon-covalentInteractionfortheDetectionofBiomarkers,Chem.Comm.201854,10726-10729. 76.X.Huang,L.P.Zhan,J.Sun,J.J.Xue,H.H.Liu,C.Q.Xiong,andZ.X.Nie*,UtilizingaMini-humidifierToDepositMatrixForMALDI-Imaging,Anal.Chem.2018,90,8309-8313. 75.J.Sun,H.H.Liu,L.P.Zhan,C.Q.Xiong,X.Huang,J.J.Xue,andZ.X.Nie*,Lasercleavableprobes-basedcellsurfaceengineeringforin-situsialoglycoproteinsprofilingbyLDImassspectrometry,Anal.Chem.2018,90,6397-6402. 74.L.P.Zhan,X.B.Xie,Y.F.Li,H.H.Liu,C.Q.Xiong,andZ.X.Nie*,DifferentiationandQuantitationofDisaccharideIsomersbyMALDI-TOF/TOFMassSpectrometry,Anal.Chem.2018,90,1525-1530. 73.H.H.Liu,Y.M.Zhou,J.Y.Wang,C.Q.Xiong,J.J.Xue,L.P.Zhan,andZ.X.Nie*,N-Phenyl-2-naphthylamineAsaNovelMALDIMatrixforAnalysisandInSituImagingofSmallMolecules,Anal.Chem.2018,90,729-736. 72.L.Z.Liu,S.Chen,Z.J.Xue,Z.Zhang,X.Z.Qiao,Z.X.Nie,D.Han,J.L.WangandT.Wang*,Bacterialcaptureefficiencyinfluidbloodstreamimprovedbybendablenanowires,Nat.Commun.2018,9,444. 71.Z.Y.Zhang,Z.Zhang,H.H.Liu,X.Mao,W.Liu,S.T.Zhang,Z.X.Nie,andX.Q.Lu*,UltratraceandrobustvisualsensorofCd2+ionsbasedonthesize-dependentopticalpropertiesofAu@g-CNQDsnanoparticlesinmicemodels,BiosensorsBioelectronics,2018,103,87-93. 70.S.H.Yang,H.H.Liu,X.Huang,L.P.Zhan,P.Q.Lou,J.J.Xue,R.Chen*,andZ.X.Nie,ThemetabolismanddistributionofimidazolealkaloidsfromLepidiummeyenii(Maca)inmousebymatrix-assistedlaserdesorption/ionizationmassspectrometryimaging,Int.J.MassSpectrom.,2018,434,93-99. 69.J.N.Wang,J.Sun,J.Y.Wang,H.H.Liu,J.J.XueandZ.X.Nie*,Hexagonalboronnitridenanosheetsasamultifunctionalbackground-freematrixtodetectsmallmoleculesandcomplicatedsamplesbyMALDImassspectrometry,Chem.Comm.2017,53,8114-8117.(Backoutsidecover). 68.X.B.Xie,Z.P.Wang,Y.F.Li,L.P.Zhan,andZ.X.Nie*,InvestigationandApplicationsofin-sourceoxidationinLiquidSampling-AtmosphericPressureAfterglowMicroplasmaionization(LS-APAG)source,J.Am.Soc.MassSpectrom.2017,28,1036-1047. 67.H.H.Liu,W.Li,Q.He,J.J.Xue,J.Y.Wang,C.Q.Xiong,X.P.Pu,andZ.X.Nie*,MassSpectrometryImagingofKidneyTissueSectionsofRatSubjectedtoUnilateralUreteralObstruction,Sci.Rep.2017,7,41954. 66.J.JXue,Y.F.Li,X.B.Xie,C.Q.Xiong,H.H.Liu,S.M.Chen,Z.X.Nie,*C.C.Chen,andJ.C.Zhao*,CharacterizationofOrganicAerosolinBeijingbyLaserDesorptionIonizationCoupledwithFourierTransformIonCyclotronResonanceMassspectrometry,AtmosphericEnvironment,2017,159,55-65. 65.R.Z.Liu,C.X.Fan,Z.L.Zhang,X.Zhao,Y.Sun,H.H.Liu,Z.X.Nie,andX.P.Pu*,EffectsofDl-3-n-butylphthalideonCerebralIschemiaInfarctioninRatModelbyMassSpectrometryImaging,J.Mol.Sci.,2017,18,2451. 64.C.Q.Xiong,X.Y.Zhou,Q.He,X.Huang,J.Y.Wang,W.-P.Peng,H.-C.Cheng,andZ.X.Nie*,Thedevelopmentofvisible-wavelengthMALDIcellmassspectrometry(CMS)forhigh-efficiencysingle-cellanalysis,Anal.Chem.2016,88,11913-11918. 63.N.Zhang,K.Zhu,C.Q.Xiong,Y.R.Jiang,H.-C.Cheng,andZ.X.Nie*,Massmeasurementofsingleintactnanoparticlesinacylindricaliontrap,Anal.Chem.2016,88,5958-5962. 62.J.Hou,Q.N.Zheng,C.Q.Xiong,C.Z.Guan,S.M.Chen,N.Zhang,Y.F.Li,Q.He,X.B.Xie,J.N.Wang,Z.X.Nie*,D.Wang*,andL.J.Wan*,AmbientElectrospraySoft-landingforPrintingNon-covalentMolecularNanostructuresusingChargedMolecularInk,Chem.Comm.2016,52,13660.(Backinsidecover). 61.N.Zhang,J.Hou,S.M.Chen,C.Q.Xiong,H.H.Liu,Y.L.Jin,J.N.Wang,Q.He,R.Zhao,andZ.X.Nie*,RapidlyProbingAntibacterialActivityofGrapheneOxidebyMassSpectrometry-basedMetaboliteFingerprinting,Sci.Rep.2016,6,28045. 60.Y.F.Li,J.N.Wang,L.P.Zhan,M.Wleklinski,J.Y.Wang,C.Q.Xiong,H.H.Liu,Y.M.Zhou,andZ.X.Nie*,TheBridgebetweenthinlayerchromatography-massspectrometryandhigh-performanceliquidchromatography-massspectrometry:Therealizationofliquidthinlayerchromatography-massspectrometry(LTLC-MS),J.Chrom.A.2016,1460,181-189. 59.J.Sun,S.M.Chen,H.H.Liu,C.Q.Xiong,J.Y.Wang,X.B.Xie,J.J.Xue,P.L.Chen,andZ.X.Nie*,Fluorographenenanosheets：Anewcarbon-basedmatrixforthedetectionofsmallmoleculesbyMALDI-TOFMS,RSCAdv.,6,99714-99719. 58.C.Q.Xiong*,X.Y.Zhou,N.Zhang,L.P.Zhan,Y.T.Chen,andZ.X.Nie*,NonlinearIonHarmonicsinthePaulTrapwithAddedOctopoleField:TheoreticalCharacterizationandNewInsightintoNonlinearResonanceEffect,J.Am.Soc.MassSpectrom.2016,27,344-351. 57.J.Hou,S.M.Chen,C.Y.Cao,H.H.Liu,C.Q.Xiong,J.N.Wang,N.Zhang,Q.He,W.G.Song,andZ.X.Nie*,FlowerlikeMgO/OrganicSaltMatrixtoAssistLDIMassSpectrometryforAnalysisofLeadinNaturalSamples,RapidCommun.MassSpectrom.,2016,30,208-216. 56.J.Sun,Q.He,J.J.Xue,C.Q.Xiong,H.H.Liu,S.M.Chen*andZ.X.Nie*,Reviewofmatrix-assistedlaserdesorption/ionizationmassspectrometryinanalysisandimagingofsmallmolecules,ScientiaSinicaChimica,2016,46,1119-1125.