肖海华 - 中国科学院化学研究所 -

个人简介

肖海华，博士，83年生，湖南衡阳人，高分子物理与化学国家重点实验室研究员。2012年于中国科学院长春应用化学研究所博士毕业后先后到美国圣母大学（2012-2014）、麻省理工学院（2014-2017）从事博士后研究。近年来，聚焦生物医用高分子的合成及其应用进行了一系列研究，工作主要围绕药物传输、基因治疗和基因编辑、免疫治疗和精准治疗等展开 2002.9–2006.7 湘潭大学高分子材料与工程系工学学士 2006.9-2012.7 中国科学院长春应用化学研究所（导师: 景遐斌研究员陈学思研究员）理学博士 2012.9–2014.8 美国圣母大学生物医学工程系博士后 2014.9–2017.7 美国麻省理工学院科郝癌症研究所博士后 2017.8–2017.11 中国科学院化学研究所高级访问学者 2017.12–至今中国科学院化学研究所研究员

研究领域

基于生物医用高分子的肿瘤抗耐药和抗转移载药体系基于生物医用高分子的精准医疗、个性化治疗和免疫治疗体系基于生物医用高分子的基因编辑技术研究高分子基因和药物传输体系的深层次作用机制研究

近期论文

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Dengshuai Wei&, Yingjie Yu&, Xingcai Zhang, Yongheng Wang, Hao Chen, Yao Zhao, Fuyi Wang,Guanghua Rong, Wenwen Wang, Xiang Kang, Jing Cai, Zehua Wang, Ji-Ye Yin, Muhammad Hanif,Yongbing Sun, Gaofeng Zha, Linxian Li, Guohui Nie, and Haihua Xiao*.Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models.ACS Nano ( IF 14.588 ) Pub Date : xxx.xxx.xxx. Jimei Zhang; Baochang Zhao; Shizhu Chen; Yongchao Wang; Yuxuan Zhang; Yufei Wang; Dengshuai Wei; Lingpu Zhang; Guanghua Rong; Yuhua Weng; Jifu Hao; Binglong Li; Xue-Qin Hou; Xiaoxu Kang; Yao Zhao; Fuyi Wang; Yongxiang Zhao; Yingjie Yu(*); Qin-Pei Wu(*); Xing-Jie Liang(*); Haihua Xiao(*),Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy,ACS Nano ( IF 14.588 ) Pub Date : 2020-10-21 , DOI: 10.1021/acsnano.0c03781. Yuanyuan Yang; Xin Liu; Wen Ma; Qing Xu; Gui Chen; Yufei Wang; Haihua Xiao; Nan Li; Xing-Jie Liang(*); Meng Yu(*); Zhiqiang Yu(*),Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy,Biomaterials ( IF 10.317 ) Pub Date : 2020-10-15 , DOI: 10.1016/j.biomaterials.2020.120456. Yuanyuan Yang#;Yingjie Yu#;Hao Chen;Xiangxi Meng;Wen Ma;Meng Yu;Ziyuan Li;Changhui Li;Haile Liu;Xiaodong Zhang(*);Haihua Xiao(*);Zhiqiang Yu(*),Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging,ACS Nano ( IF 14.588 ) Pub Date : 2020-09-14 , DOI: 10.1021/acsnano.0c05541. Xinmiao Lan;Wangyong Zhu;Xinshuo Huang;Yingjie Yu;Haihua Xiao;Lijian Jin;Jingya Jane Pu;Xi Xie;Juncong She;Vivian Wai Yan Lui;Hui-Jiuan Chen(*);Yu-Xiong Su(*),Microneedles loaded with anti-PD-1-cisplatin nanoparticles for synergistic cancer immuno-chemotherapy,Nanoscale ( IF 6.895 ) Pub Date : 2020-09-09 , DOI: 10.1039/d0nr04213g. Tiantian Wu;Manman Liu;Hai Huang;Yaping Sheng;Haihua Xiao;Yangzhong Liu(*),Clustered nanobody-drug conjugates for targeted cancer therapy,Chemical Communications ( IF 5.996 ) Pub Date : 2020-07-16 , DOI: 10.1039/d0cc03396k. Tongren Yang;Chunhui Li;Xiaoxia Wang;Deyao Zhao;Mengjie Zhang;Huiqing Cao;Zicai Liang;Haihua Xiao;Xing-Jie Liang;Yuhua Weng(*);Yuanyu Huang(*),Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle,Bioactive materials Pub Date : 2020-07-13 , DOI: 10.1016/j.bioactmat.2020.07.003. Payel Datta;Scott Bang;Zhizhou Yue;Travis Beach;Morgan Stilgenbauer;Han Wang;David J Bowers;Manabu Kurokawa;Haihua Xiao;Yao-Rong Zheng(*),Engineering liposomal nanoparticles of cholesterol-tethered amphiphilic Pt(iv) prodrugs with prolonged circulation time in blood,Dalton Transactions ( IF 4.174 ) Pub Date : 2020-05-28 , DOI: 10.1039/d0dt01297a. Yingjie Yu; Fanqiang Bu; Huiling Zhou; Yongheng Wang; Jianxun Cui; Xing Wang; Guohui Nie; Haihua Xiao(*),Biosafety materials: an emerging new research direction of materials science from the COVID-19 outbreak,Materials Chemistry Frontiers ( IF 6.788 ) Pub Date : 2020-05-12 , DOI: 10.1039/d0qm00255k Ruogu Qi;Yongheng Wang;Peter M Bruno;Haihua Xiao;Yingjie Yu;Ting Li;Sam Lauffer;Wei Wei;Qixian Chen;Xiang Kang;Haiqin Song;Xi Yang;Xing Huang;Alexandre Detappe;Ursula Matulonis;David Pepin;Michael T Hemann;Michael J Birrer(*);P Peter Ghoroghchian(*),Author Correction: Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer.Nature Communications ( IF 12.121 ) Pub Date : 2020-04-17 , DOI: 10.1038/s41467-020-14903-y. Fang Ding;Lingpu Zhang;Hao Chen;Haiqin Song(*);Shiguo Chen(*);Haihua Xiao(*),Enhancing the chemotherapeutic efficacy of platinum prodrug nanoparticles and inhibiting cancer metastasis by targeting iron homeostasis. Nanoscale Horizons ( IF 9.927 ) Pub Date : 2020-04-16 , DOI: 10.1039/d0nh00148a. Teng Zhang;Jingwei Gu;Xiangyu Liu;Dengshuai Wei;Huiling Zhou;Haihua Xiao;Zhuocheng Zhang;Huali Yu;Shiguo Chen(*),Bactericidal and antifouling electrospun PVA nanofibers modified with a quaternary ammonium salt and zwitterionic sulfopropylbetaine,Materials Science and Engineering: C ( IF 5.880 ) Pub Date : 2020-03-14 , DOI: 10.1016/j.msec.2020.110855. Yuhua Weng;Chunhui Li;Tongren Yang;Bo Hu;Mengjie Zhang;Shuai Guo;Haihua Xiao;Xing-Jie Liang;Yuanyu Huang(*),The challenge and prospect of mRNA therapeutics landscape. Biotechnology Advances ( IF 10.744 ) Pub Date : 2020-02-21 , DOI: 10.1016/j.biotechadv.2020.107534. Lang Rao; Guang‐Tao Yu; Qian‐Fang Meng; Lin‐Lin Bu; Rui Tian; Li‐Sen Lin; Hongzhang Deng; Weijing Yang; Minghui Zan; Jianxun Ding; Andrew Li; Haihua Xiao(*); Zhi‐Jun Sun(*); Wei Liu(*); Xiaoyuan Che(*),Cancer Cell Membrane‐Coated Nanoparticles for Personalized Therapy in Patient‐Derived Xenograft Models, Adv. Funct. Mater, 2019, 1905671. Jiaxu Li; Liuchun Zheng(*); Haihua Xiao(*); Chuncheng Li(*); Shaohua Wu; Yaonan Xiao; Jiajian Liua and Bo Zhanga, Design of zwitterionic polyester based nanocarriers for platinum(IV) prodrug delivery, Polymer Chemistry, 2019, 10, 5353 Tiantian Wu; Jianbing Liu; Manman Liu; Shaoli Liu; Shuai Zhao; Run Tian; Dengshuai Wei; Yangzhong Liu; Yao Zhao; Haihua Xiao; Baoquan Ding(*),A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum Drug Delivery, Angew. Chem. Int. Ed, 2019, DOI: 10.1002/anie.201909345 Binbin Ding; Shuai Shao; Haihua Xiao;Chunqiang Sun; Xuechao Cai; Fan Jiang; Xueyan Zhao; Ping'an Ma (*), and Jun Lin (*),MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O2 self-sufficient photodynamic therapy, Nanoscale, 2019.7.18, DOI:10.1039 / C9NR04858H Guyu Zhang; Yimin Zhu; Yushu Wang; Dengshuai Wei; Yixin Wu;Liuchun Zheng; Huimin Bai(*), Haihua Xiao(*), and Zhenyu Zhang, pH/redox sensitive nanoparticles with platinum(IV) prodrugs and doxorubicin enhance chemotherapy in ovarian cancer, RSC Adv, 2019.7.2, 9, 20513-20517 Lawrence B. Mensah; Stephen W. Morton; Jiahe Li ; Haihua Xiao ; Mohiuddin A. Quadir ; Kevin M. Elias ; Emily Penn ; Aysen K. Richson ; Paiman Peter Ghoroghchian ; Joyce Liu ; Paula T. Hammond (*), Layer-by-layer nanoparticles for novel delivery of cisplatin and PARP inhibitors for platinum-based drug resistance therapy in ovarian cancer, Bioengineering & Translational Medicine, 2019.5.15, 4(2): e10131 Xiaoxu Kang; Yingjie Yu; Zhigang Chen; Yixin Wu; Dengshuai Wei; Yao Zhao; Fuyi Wang ; Haihua Xiao(*), A negatively charged Pt(IV) prodrug for electrostatic complexation with polymers to overcome cisplatin resistance, J. Mater. Chem. B, 2019.4.18, 7, 3346