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个人简介

简介: 1982年毕业于山东大学光学系。1988年8月于中国科学院物理研究所获博士学位。随后在中科院物理所工作至今。其间先后在意大利佛罗伦萨国家光学研究所(1989年9月-1991年12月,F.T.Arecchi教授研究组)、法国里尔大学(1991年12月-1992年12月,PierreGlorieux教授研究组)、丹麦Risø国家实验室(1998年10月-1999年3月,MarkSaffman教授研究组)、英国爱丁堡Heriot-Watt大学(1999年3月-2000年3月,R.G.Harrison教授研究组)、美国斯坦福大学(2006年5月-8月,诺贝尔物理学奖获得者朱棣文StevenChu教授研究组)和哈佛大学(2010年5月-11月,谢晓亮XiaoliangSunneyXie教授研究组)进行访问研究。曾获杰青。现任国科大教授。 过去的主要工作及获得的成果: 近年来,进入了物理学与生命科学交叉研究领域。负责成立了“复杂系统和生物大分子的动力学”研究组,担任组长(1999年-至今)。负责成立了“中科院物理所软物质物理实验室”,担任首届主任(2001年-2009年)。研究了单分子DNA熔化、凝聚、DNA与组蛋白(histone)的相互作用、解旋酶(helicase)的动力学行为、生物分子马达(molecularmotor)的动力学行为、抗癌药物顺铂(cisplatin)奥沙利铂(oxaliplatin)及反铂(transplatin)与DNA的作用机理、单细胞中紫杉醇对表皮生长因子受体(EGFR)内吞运输的影响、量子点在活细胞内的扩散运动等。在《PhysicalReviewLetters》,《PhysicalReviewA,E》,《OpticsLetters》,《AppliedPhysicsLetters》,《ChinesePhysicsLetters》,《ChinesePhysicsB》,《JournalofChemicalPhysics》,《JournaloftheAmericanChemicalSociety》,《JournalofBiologicalChemistry》,《JournalofTheoreticalBiology》,《JournalofMolecularBiology》,《Biochemistry》,《NucleicAcidsResearch》,《MolecularCell》,《ScienceChina》,《ChineseScienceBulletin》,《PNAS》,《Nature》等物理学、化学、生物学及综合杂志上发表学术论文百余篇。2000年获“国家杰出青年科学基金”。 目前的研究课题及展望: 上述研究方向中的研究课题是国际上的研究热点,具有巨大的发展潜力和广泛的国际合作基础。我们的实验室目前具有高精度荧光显微镜(包括镜下细胞培养系统)、高灵敏成像设备、单分子操纵设备(磁镊)、快速停流设备、原子力显微镜、各种先进的生化设备等,另外还有并行计算服务器。装备水平居世界前列。欢迎有志的年轻学子加入到这一研究中来。无论是物理、化学、生物、基础医学背景的学生均受欢迎。特别欢迎各高校的优秀推荐生。 培养研究生情况: 已毕业博士研究生16名,在读博士研究生7名。

研究领域

主要研究方向: 复杂系统和生物大分子的动力学研究。包括的研究课题:1.抗癌药物与DNA及活细胞的作用;2.DNA与蛋白质的相互作用动力学;3.生物分子马达的动力学;4.利用量子点观察活细胞;5.单分子操纵和单细胞动态成像。

近期论文

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代表性论文及专利: 部分已发表的学术论文: BoLi,Shuo-XingDou,Jing-WenYuan,Yu-RuLiu,WeiLi,FangfuYe,Peng-YeWang,HuiLi“Intracellulartransportisacceleratedinearlyapoptoticcells”ProcNatlAcadSciUSA115,12118(2018) Xi-MingLu,HuiLi,JingYou,WeiLi,Peng-YeWang,MingLi,Shuo-XingDou,Xu-GuangXi“FoldingDynamicsofParallelandAntiparallelG‑TriplexesundertheInfluenceofProximalDNA”J.Phys.Chem.B122,9499(2018) XueXiao,LipingDong,Yi-ZhouWang,Peng-YeWang,MingLi,GuohongLi,PingChen,WeiLi“Dissectionofstructuraldynamicsofchromatinfibersbysingle-moleculemagnetictweezers”BiophysRep4,222(2018) Xiao-XuanShi,Yi-BenFu,Si-KaoGuo,Peng-YeWang,HongChen,PingXie“Investigatingroleofconformationalchangesofmicrotubuleinregulatingitsbindingaffinitytokinesinbyall-atommoleculardynamicssimulation”Proteins86,1127(2018) BoLi,ChaoJi,Xi-MingLu,Yu-RuLiu,WeiLi,Shuo-XingDou,HuiLi,Peng-YeWang“EffectofTorsiononCisplatin-InducedDNACondensation”CHIN.PHYS.LETT.35,118701(2018) Si-KaoGuo,Xiao-XuanShi,Peng-YeWang,PingXie“Processivityofdimerickinesin-1molecularmotors”FEBSOpenBio8,1332(2018) PingChen,LipingDong,MingliHu,Yi-ZhouWang,XueXiao,ZhongliangZhao,JieYan,Peng-YeWang,DannyReinberg,MingLi,WeiLi,GuohongLi“FunctionsofFACTinBreakingtheNucleosomeandMaintainingItsIntegrityattheSingle-NucleosomeLevel”MolecularCell71,284(2018) Yi-ZhouWang,Xi-MiaoHou,Hai-PengJu,XueXiao,Xu-GuangXi,Shuo-XingDou,Peng-YeWang,WeiLi“InteractionbetweenhumantelomericG-quadruplexescharacterizedbysinglemoleculemagnetictweezers”Chin.Phys.B27,068701(2018) HuiLi,FangfuYe,Jing-YiRen,Peng-YeWang,Li-LinDu,Ji-LongLiu“ActivetransportofcytoophidiainSchizosaccharomycespombe”FASEBJ.32,doi:10.1096/fj.201800045RR(2018) Yi-BenFu,Yu-RuLiu,Peng-YeWang,PingXie“ARevisedWorm-LikeChainModelforElasticityofPolypeptideChains”J.Polym.Sci.PartB:Polym.Phys.56,297(2018) JingYou,HuiLi,Xi-MingLu,WeiLi,Peng-YeWang,Shuo-XingDou,Xu-GuangXi“EffectsofmonovalentcationsonfoldingkineticsofG-quadruplexes”BioscienceReports37,20170771(2017) Si-KaoGuo,Peng-YeWang,PingXie“Dynamicsofdimerickinesins:Limping,effectoflongitudinalforce,effectsofnecklinkerextensionandmutation,andcomparisonbetweenkinesin-1andkinesin-2”InternationalJournalofBiologicalMacromolecules105,1126(2017) Xi-MiaoHou,Yi-BenFu,Wen-QiangWu,LeiWang,Fang-YuanTeng,PingXie,Peng-YeWang,Xu-GuangXi“InvolvementofG-triplexandG-hairpininthemulti-pathwayfoldingofhumantelomericG-quadruplex”NucleicAcidsResearch45,11401(2017) Zhan-FengWang,Yu-RuLiu,Peng-YeWang,PingXie“AnintermediatestateofT7RNApolymeraseprovidesanotherpathwayofnucleotideselection”Chin.Phys.B26,100203(2017) LüXi-Ming,LiHui,YouJing,LiWei,WangPeng-Ye,LiMing,XiXu-Guang,DouShuo-Xing“Anoptimizationalgorithmforsingle-moleculefluorescenceresonance(smFRET)dataprocessing”ActaPhys.Sin.66,118701(2017) JingYou,Ya-NanXu,HuiLi,Xi-MingLu,WeiLi,Peng-YeWang,Shuo-XingDou,Xu-GuangXi“HelicaseactivityandsubstratespecificityofRecQ5beta”Chin.Phys.B26,068701(2017) Zhan-FengWang,Yi-BenFu,Peng-YeWang,PingXie“DynamicsofbridgehelixbendinginRNApolymeraseII”Proteins85,614(2017) Zhan-FengWang,Zhi-QiangZhang,Yi-BenFu,Peng-YeWang,PingXie“BrownianratchetmechanismoftranslocationinT7RNApolymerasefacilitatedbyapost-translocationenergybiasarisingfromtheconformationalchangeoftheenzyme”Chin.Phys.B26,030201(2017) Si-KaoGuo,Peng-YeWang,PingXie“Amodelofprocessivemovementofdimerickinesin”JournalofTheoreticalBiology414,62(2017) WeiLi,PingChen,JuanYu,LipingDong,DanLiang,JianxunFeng,JieYan,Peng-YeWang,QingLi,ZhiguoZhang,MingLi,GuohongLi“FACTRemodelstheTetranucleosomalUnitofChromatinFibersforGeneTranscription”MolecularCell64,120(2016) Hai-PengJu,Yi-ZhouWang,JingYou,Xi-MiaoHou,Xu-GuangXi,Shuo-XingDou,WeiLi,Peng-YeWang“FoldingKineticsofSingleHumanTelomericG‑QuadruplexAffectedbyCisplatin”ACSOmega1,244(2016) Qing-JiShen,HakimiKassim,YongHuang,HuiLi,JingZhang,GuangLi,Peng-YeWang,JunYan,FangfuYe,Ji-LongLiu“FilamentationofMetabolicEnzymesinSaccharomycescerevisiae”JournalofGeneticsandGenomics43,393(2016) Yi-BenFu,Zhan-FengWang,Peng-YeWang,PingXie“OptimalnumbersofresiduesinlinkersofDNApolymeraseI,T7primaseandDNApolymeraseIV”Sci.Rep.6,29125(2016) YuruLiu,PingXie,PengyeWang,MingLi,HuiLi,WeiLi,ShuoxingDou“AmodelforchromosomeorganizationduringthecellcycleinliveE.coli”Sci.Rep.5,17133(2015) LiWei,WongWei-Juan,LimCi-Ji,JuHai-Peng,LiMing,YanJie,WangPeng-Ye“Catch-bondbehaviorofDNAcondensateundertension”Chin.Phys.B24,128704(2015) HuiLi,Shuo-XingDou,Yu-RuLiu,WeiLi,PingXie,Wei-ChiWang,Peng-YeWang“MappingIntracellularDiffusionDistributionUsingSingleQuantumDotTracking:CompartmentalizedDiffusionDefinedbyEndoplasmicReticulum”J.Am.Chem.Soc.137,436(2015) WeiLi,WeiJuanWong,CiJiLim,Hai-PengJu,MingLi,JieYan,Peng-YeWang“ComplexkineticsofDNAcondensationrevealedthroughDNAtwisttracing”Phys.Rev.E92,022707(2015) ZhiZhou,YingHu,XinyanShan,WeiLi,XuedongBai,PengyeWang,XinghuaLu“RevealingThreeStagesofDNACisplatinReactionbyaSolid-StateNanopore”ScientificReports5,11868(2015) Hong-YanZhang,Yu-RuLiu,WeiLi,HuiLi,Shuo-XingDou,PingXie,Wei-ChiWang,Peng-YeWang“CondensationsofsingleDNAmoleculesinducedbyheptaplatinanditschiralisomer”AIPAdvances4,087128(2014) JUHaiPeng,ZHANGHongYan,LIWei,WANGPengYe“EffectsofoxaliplatinonDNAcondensation”ScienceChina57,2114(2014) ZHANGHong-Yan,JIChao,LIUYu-Ru,LIWei,LIHui,DOUShuo-Xing,WANGWei-Chi,ZHANGLing-Yun,XIEPing,WANGPeng-Ye“EffectsofpHonOxaliplatin-InducedCondensationofSingleDNAMolecules”Chin.Phys.Lett.31,028701(2014) ChaoJi,LingyunZhang,ShuoxingDou,PengyeWang“LocalconformationtransitionsoflinearDNAinducedbycisplatin”Chin.Sci.Bull.59,3085(2014) Hong-YanZhang,Yu-RuLiu,ChaoJi,WeiLi,Shuo-XingDou,PingXie,Wei-ChiWang,Ling-YunZhang,Peng-YeWang“OxaliplatinanditsenantiomerinducedifferentcondensationdynamicsofsingleDNAmolecules”PLoSOne8,e71556(2013) Yu-RuLiu,ChaoJi,Hong-YanZhang,Shuo-XingDou,PingXie,Wei-ChiWang,Peng-YeWang“TransplatinenhanceseffectofcisplatinonbothsingleDNAmoleculesandlivetumorcells”Arch.Biochem.Biophys.536,12(2013) WeiLi,Xi-MiaoHou,Peng-YeWang,Xu-GuangXi,MingLi“DirectMeasurementofSequentialFoldingPathwayandEnergyLandscapeofHumanTelomericG-quadruplexStructures”J.Am.Chem.Soc.135,6423(2013) ChaoJi,LingyunZhang,Peng-YeWang“QuantitativeanalysisoftheflexibilityeffectofcisplatinoncircularDNA”Phys.Rev.E88,042703(2013) WeiLi,Peng-YeWang,JieYan,MingLi“ImpactofDNATwistAccumulationonProgressiveHelicalWrappingofTorsionallyConstrainedDNA”Phys.Rev.Lett.109,218102(2012) HuiLi,Zhao-WenDuan,PingXie,Yu-RuLiu,Wei-ChiWang,Shuo-XingDou,Peng-YeWang“EffectsofPaclitaxelonEGFREndocyticTraffickingRevealedUsingQuantumDotTrackinginSingleCells”PLoSOne7,e45465(2012) Ya-NanXu,NicolasBazeille,Xiu-YanDing,Xi-MingLu,Peng-YeWang,ElisabethBugnard,VirginieGrondin,Shuo-XingDou,XuGuangXi“MultimericBLMisdissociateduponATPhydrolysisandfunctionsasmonomersinresolvingDNAstructures”NucleicAcidsRes.40,9802(2012) ZHANGZhiQiang,LIUYuRu,XIEPing,LIWei,DOUShuoXing,WANGPengYe“StudyingtheinteractionbetweengyraseandDNAusingmagnetictweezers”Chin.Sci.Bull.57,3560(2012) Zhao-WenDuan,PingXie,WeiLi,Peng-YeWang“AreCoiled-CoilsofDimericKinesinsUnwoundduringTheirWalkingonMicrotubule?”PLoSOne7,e36071(2012) WeiLi,Zhi-QiangSun,PingXie,Shuo-XingDou,Wei-ChiWang,Peng-YeWang“ElasticresponseandlengthchangeofsingleDNAmoleculesinducedbyacombinationofcisplatinandtransplatin”Phys.Rev.E85,021918(2012) JunHuang,HuiLi,WeiChen,Guo-HuaLv,Xing-QuanWang,Guo-PingZhang,KostyaOstrikov,Peng-YeWang,Si-ZeYang“DielectricbarrierdischargeplasmainAr/O2promotingapoptosisbehaviorinA549cancercells”Appl.Phys.Lett.99,253701(2011) JIChao,ZHANGLing-Yun,HOUXi-Miao,DOUShuo-Xing,WANGPeng-Ye“EffectofCisplatinontheFlexibilityofLinearDNA”Chin.Phys.Lett.28,068702(2011) Bing-YiPan,Shuo-XingDou,YeYang,Ya-NanXu,ElisabethBugnard,Xiu-YanDing,LingyunZhang,Peng-YeWang,MingLi,andXuGuangXi“MutualInhibitionofRecQMoleculesinDNAUnwinding”J.Biol.Chem.285,15884(2010) SUNZhi-Qiang,XIEPing,LIWei,WANGPeng-Ye“SpikingRegularityandCoherenceinComplexHodgkin–HuxleyNeuronNetworks”Chin.Phys.Lett.27,088702(2010) YeYang,Shuo-XingDou,Ya-NanXu,NicolasBazeille,Peng-YeWang,PascalRigolet,Hou-QiangXuandXuGuangXi“KineticMechanismofDNAUnwindingbytheBLMHelicaseCoreandMolecularBasisforItsLowProcessivity”Biochemistry49,656(2010) CongxinLi,XiaofangChen,PengyeWangandWeichiWang“CircadianKaiCPhosphorylation:AMulti-LayerNetwork”PLoSComput.Biol.5,e1000568(2009) Bing-YiPan,LingyunZhang,Shuo-XingDouandPeng-YeWang“Forces-inducedpinpointdenaturationofshortDNA”Biochem.Biophys.Res.Commun.388,137(2009) YiWang,YongjianHuang,JiaweiWang,ChaoCheng,WeijiaoHuang,PeilongLu,Ya-NanXu,PengyeWang,NiengYanandYigongShi“StructureoftheformatetransporterFocArevealsapentamericaquaporin-likechannel”Nature462,467(2009) Xi-MiaoHou,Xing-HuaZhang,Kong-JiWei,ChaoJi,Shuo-XingDou,Wei-ChiWang,MingLiandPeng-YeWang“CisplatininducesloopstructuresandcondensationofsingleDNAmolecules”NucleicAcidsRes.37,1400(2009) Xi-MiaoHou,WeiLi,Shuo-XingDou,Ling-YunZhang,PingXie,Wei-ChiWangandPeng-YeWang“FormationofDNAtoroidsinsideconfineddropletsadsorbedonmicasurfaces”Phys.Rev.E79,051912(2009) WANGHong,DOUShuo-Xing,WANGPeng-Ye“MonteCarloSimulationonCoordinatedMovementofKinesinandDyneinMotors”Chin.Phys.Lett.25,321(2008) Xiao-fangChen,Cong-xinLi,Peng-yeWang,MingLi,Wei-chiWang“Dynamicsimulationoftheeffectofcalcium-releaseactivatedcalciumchanneloncytoplasmicCa2+oscillation”BiophysicalChemistry136,87(2008) YeYang,Shuo-XingDou,HuaRen,Peng-YeWang,Xing-DongZhang,MinQian,Bing-YiPanandXuGuangXi”EvidenceforafunctionaldimericformofthePcrAhelicaseinDNAunwinding”NucleicAcidsRes.36,1976(2008) WANGPeng-Ye,LIMing,WENGYu-Xiang“Recentprogressinbiologicalsoftmatterresearch”Physics(WULI)37,441(2008) WeiLi,Shuo-XingDou,PingXie,andPeng-YeWang“Browniandynamicssimulationoftheeffectofhistonemodificationonnucleosomestructure”Phys.Rev.E75,051915(2007) Rong-BingGuo,PascalRigolet,HuaRen,BoZhang,Xing-DongZhang,Shuo-XingDou,Peng-YeWang,MouniraAmor-GueretandXuGuangXi“Structuralandfunctionalanalysesofdisease-causingmissensemutationsinBloomsyndromeprotein”NucleicAcidsRes.356297(2007) YongZhang,XinZhao,Peng-YeWang“MoleculardynamicsstudyofthefibrilelongationoftheprionproteinfragmentPrP106–126”J.Theor.Biol.245,238(2007) PingXie,Shuo-XingDou,Peng-YeWang“Limpingofhomodimerickinesinmotors”J.Mol.Biol.366,976(2007) Kai-GeWang,ShuanglinYue,LeiWang,AiziJin,ChangzhiGu,Peng-YeWang,YuchunFeng,YunchengWang,HanbenNiu“ManipulatingDNAmoleculesinnanofluidicchannels”MicrofluidNanofluid2,85(2006) JunQian,PingXie,Shuo-XingDou,Peng-YeWang“Amodelforbiaseddiffusionofcollagenasealongcollagenfibrils”J.Theor.Biol.243,322(2006) PingXie,Shuo-XingDou,Peng-YeWang“Modelforkineticsofmyosin-Vmolecularmotors”BiophysicalChemistry120,225(2006) WeiLi,Shuo-XingDou,PingXie,Peng-YeWang“BrowniandynamicssimulationofdirectionalslidingofhistoneoctamerscausedbyDNAbending”Phys.Rev.E73,051909(2006) Xing-DongZhang,Shuo-XingDou,PingXie,Jin-ShanHu,Peng-YeWang,XuGuangXi“E.coliRecQisarapid,efficientandmonomerichelicase”J.Biol.Chem.281,12655(2006) WeiLi,Shuo-XingDou,Peng-YeWang“ThehistoneoctamerinfluencesthewrappingdirectionofDNAonit:Browniandynamicssimulationofthenucleosomechirality”J.Theor.Biol.235,365(2005) QianJun,XiePing,DouShuo-Xing,WangPeng-Ye“NumericalstudyofthecouplingbetweenF0withvariednumbersofc-subunitsandF1inanATPsynthase”Chin.Phys.14,2214(2005) XiePing,DouShuo-Xing,WangPeng-Ye“Amodelforprocessivityofmolecularmotors”Chin.Phys.13,1569(2004) Yu-YingLiu,Peng-YeWang,Shuo-XingDou,Wei-ChiWang,PingXie,Hua-WeiYin,Xing-DongZhang,XuGuangXi“IoniceffectoncombingofsingleDNAmoleculesandobservationoftheirforce-inducedmeltingbyfluorescencemicroscopy”J.Chem.Phys.121,4302(2004) WeiLi,Shuo-XingDou,Peng-YeWang“Browniandynamicssimulationofnucleosomeformationanddisruptionunderstretching”J.Theor.Biol.230,375(2004) WangPeng-Ye,XiePing,YinHua-Wei“Controlofspiralwavesandturbulentstatesinacardiacmodelbytravelling-waveperturbations”Chin.Phys.12,674(2003) Peng-YeWang,WeipingLu,DejinYu,RobertG.Harrison“ExcitabilityandpatternformationinaliquidcrystalFabry–Pérotinterferometer”OpticsCommunications189,127(2001) Peng-YeWang,PingXie“Eliminatingspatiotemporalchaosandspiralwavesbyweakspatialperturbations”Phys.Rev.E61,5120(2000) Peng-YeWang,M.Saffman“Selectingopticalpatternswithspatialphasemodulation”OpticsLetters24,1118(1999) Peng-YeWang“First-Passage-TimeDistributionsoftheFreederickszTransitioninNematicLiquidCrystals”MolecularCrystalsandLiquidCrystals319,1(1998) M.Ciofini,A.Labate,R.Meucci,Peng-YeWang“ExperimentalevidenceofselectionandstabilizationofspatialpatternsinaCO2laserbymeansofspatialperturbations”OpticsCommunications154,307(1998) Peng-YeWang,PingXie,Jian-HuaDai,Hong-JunZhang“Stabilization,Selection,andTrackingofUnstablePatternsbyWeakSpatialPerturbations”Phys.Rev.Lett.80,4669(1998) Peng-YeWang“TransientStatisticsoftheFreederickszTransitioninNematicLiquidCrystals”MolecularCrystalsandLiquidCrystals302,397(1997) J.C.Garreau,Peng-YeWang,P.Glorieux“Bitcorrelationandmemoryeffectsinhigh-speedpumpmodulationofafiberlaser”IEEEJournalofQuantumElectronics30,1058(1994) 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