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研究领域

1,有机催化和金属催化新型方法学的研究及应用.2,靶向性设计和合成相关疾病的潜在药物活性分子.

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Liu,L.; Wu, D.; Zheng, S.; Li, T.; Li, X.; Wang, S.; Li, J.; Li, H.; *, Wang, W. * Synthesis of Highly Functionalized Chiral 3,3′-Disubstituted Oxindoles via an Organocatalytic Enantioselective Michael Addition of Nitroalkanes to Indolylidenecyanoacetates Org. Lett., 2012, 14, 134–137. Li, H.; Song, F.; Widenhoefer, R. A. * Gold(I)-Catalyzed Intramolecular Hydroamination of N-Allylic N'-Arylureas to form Imidazolidin-2-ones. Advanced Synthesis & Catalysis 2011, 353, 955-962. Zhang, S.; Xie, H.; Zhu, J.; Li, H.; Zhang, X.; Li, J.;* Wang, W.* Organocatalytic enantioselective b-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions. Nature Communications 2011, 2, 1214/1-1214/7. Li, H.; Lee, S.; Widenhoefer, R. A.* Gold(I)-catalyzed enantioselective intramolecular hydroamination of allenes with ureas. Journal of Organometallic Chemistry 2010, 696, 316-320. Li, H.; Ji, Y.-F.; Li, J.; Zhang, S.-L.; Yu, C.-G.; Wang, W.* “Organocatalytic Enantioselective Michael Addition Reactions of Fluoromalonates with a, b-Unsaturated Aldehydes” Science China – Chemistry, 2010, 53, 135-139. Li, H.; Widenhoefer, R.* “Intramolecular diamination and alkoxyamination of alkenes with N-sulfonylureas employing N-iodosuccinimide” Tetrahedron 2010, 4827-4831. Li, H.; Zu, L.; Xie, H.; Wang, W.* “Organocatalytic Enantioselective Conjugate Addition of 2-Fluoromalonate to Nitroolefins: Direct Synthesis of Chiral Fluorinated g-Nitro Carboxylic Acid Derivatives” Synthesis, 2009, 1525-1530, invited Special Topics. Li, H.; Widenhoefer, R.* “Gold(I)-Catalyzed Intramolecular Dihydroamination of Allenes with N,N′-Disubstituted Ureas To Form Bicyclic Imidazolidin-2-ones” Org. Lett., 2009, 11, 2671-2674. Li, H.; Zhang, S.-L.; Yu, C. G.; Song, X.-X.; Wang, W.* “Synthesis of Chiral Fluorinated Quaternary Carbon Containing b-Ketoesters” Chem. Commun., 2009, 2136-2138. Li, H.; Zu, L.-S.; Xie, H.-X.; Wang, J.; Wang, W.* “Highly Enantio- and Diastereoselective Organocatalytic Cascade aza-Michael-Michael Reactions: A Direct Method for the Synthesis of Trisubstituted Chiral Pyrrolidines” Chem. Commun., 2008, 5636-5638. This work has been highlighted in Organic Chemistry Highlights as “New methods for C-N ring construction.” by Organic Chemistry Fu, Z.; Malureanu, L.; Huang, J.; Wang, W.; Li, H.; van Deursen, J. M.; Tindall, D. J.;* Chen, J.* “Plk1-dependent Phosphorylation of FoxM1 Regulates a Transcriptional Program Required for Mitotic Progression” Nature Cell Biol., 2008, 10, 1076-1082. Wang, J.; Xie, H.-X.; Li, H.; Zu, L.-S.; Wang, W.* “A Highly Stereoselective Hydrogen-bond Mediated Cascade Michael-Michael Process through Dynamic Kinetic Resolution” Angew. Chem. Int. Ed., 2008, 47, 4177-4179. This work has been selected as “hot” paper by Angew. Chem. Editors. Li, H.; Zu, L.-S.; Xie, H.-X.; Wang, J.; Jiang, W.; Wang, W.* “Enantioselective Organocatalytic Double Michael Addition Reactions” Org. Lett., 2007, 9, 1833-1835. This work has been highlighted in Synfacts and Organic Chemistry Highlights Li, H.; Wang, J.; Xie, H.-X.; Zu, L.-S.; Jiang, W.; Duesler, E. N.; Wang, W.* “Enantioselective Organocatalytic Cascade Reactions: Facile Synthesis of Chiral 1,2-Dihydroquinolines” Org. Lett., 2007, 9, 965-968. This work has been recognized as the “Most-cited” and “Hot” paper of OL. Li, H.; Wang, J.; E-Nunu, T.; Zu, L.-S.; Jiang, W.; Wei, S.-H.; Wang, W.* “One-Pot Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino Oxa-Michael-Aldol Reaction” Chem. Commun., 2007, 507-509. This work has been recognized as top 5 (number 2) the “Most cited” paper published on Chem. Commun. since 2007. Wang, J.; Li, H.; Xie, H.-X.; Zu, L.-S.; Shen, X.; Wang, W.* “Organocatalytic Enantioselective Cascade Michael-Aldol-Dehydration Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes” Angew. Chem. Int. Ed., 2007, 46, 9050-9053. This article has been selected as “Hot paper” by ACIE. Xie, H.-X.; Zu, L.-S.; Li, H.; Wang, J.; Wang, W.* “Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions. Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes” J. Am. Chem. Soc., 2007, 129, 10886-10894. This work has been highlighted in Synfacts. Zu, L.-S.; Wang, J.; Li, H.; Xie, H.-X.; Jiang, W.; Wang, W.* “Cascade Michael-aldol Reactions Promoted by Hydrogen-Bonding Mediated Catalysis” J. Am. Chem. Soc., 2007, 129, 1036-1037. This work has been recognized as the “Most-cited” and “Hot” paper of JACS. Zu, L.-S.; Li, H.; Xie, H.-X.; Wang, J.; Jiang, W.; Tang, T.; Wang, W.* “Synthesis of Highly Functionalized Chiral Cyclopentanes by Catalytic Enantio- and Diastereoselective Double Michael Addition Reactions” Angew Chem. Int. Ed., 2007, 46, 3732-3734. This work has been highlighted in Synfacts. Wang, J.; Li, H.; Zu, L.-S.; Jiang, W.; Xie, H.-X.; Duan, W.-H.; Wang, W.* “Enantioselective Organocatalytic Conjugate Additions to Enones” J. Am. Chem. Soc., 2006, 128, 12652-12653. This work has been recognized as the “Most-cited” and “Hot” Paper of J. Am. Chem. Soc.. Wang, W.;* Li, H.; Wang, J.; Zu, L.-S.; “Enantioselective Organocatalytic Tandem Michael-Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes” J. Am. Chem. Soc., 2006, 128, 10354-10355. This work has been recognized as the “Most-cited” and “Hot” Paper of J. Am. Chem. Soc. and highlighted in Synfacts. Wang, W.;* Wang, J.; and Li, H. “Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes” Angew. Chem. Int. Ed., 2005, 44, 1369-1371. This work is the most cited paper of Angew. Chem. Int. Ed. in year 2005/2006 and has been highlighted in Org. Chem. Highlights 2006, January 30. Li, H.; Wang, J.; Zu, L.-S.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to b-Nitrostyrenes” Tetrahedron Lett., 2006, 47, 2585-2589. Li, H.; Zu, L.-S.; Wang, J.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to ?Enones” Tetrahedron Lett., 2006, 47, 3145-3148. Wang, W.;* Li, H.; Wang, J. “Enantioselective, Organocatalytic Mukaiyama-Michael Addition of Silyl Ethers to a, b-Unsaturated Aldehydes” Org. Lett., 2005, 7, 1637-1639

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