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Weiwei Huang, Yi Huang, Jiayan Cui, Yuhang Wu, Fuli Zhu, Jin Huang*, Lei Ma*. Design and synthesis of Osthole-based compounds as potential Nrf2 agonists. Bioorg Med Chem Lett. 2022 Apr 1; 61: 128547.
Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie*, Jin Huang*, Yonghui Wang*. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13; 65(1): 592-615.
Zengrui Wu, Hui Ma, Zehui Liu, Lulu Zheng, Zhuohang Yu, Shuying Cao, Wenqing Fang, Lili Wu, Weihua Li, Guixia Liu, Jin Huang*, Yun Tang*. wSDTNBI: a novel network-based inference method for virtual screening. Chem Sci. 2021 Dec 21; 13(4): 1060-1079.
Xi Liu, Qian Hu, Wanyan Wang, Hui Ma, Jiaqian Pu, Jiayan Cui, Ting Gong, Yu Wu, Weiqiang Lu*, Jin Huang*. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer. Biochem Pharmacol. 2021 Jun; 188: 114583.
Wanyan Wang, Jiayan Cui, Hui Ma, Weiqiang Lu, Jin Huang*. Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine. Front Oncol. 2021 May 28; 11: 684961.
Wanyan Wang, Yu Wu, Si Chen, Xi Liu, Jiacheng He, Shuyi Wang, Weiqiang Lu*, Yong Tang*, Jin Huang*. Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer.Phytother Res. 2021 Jan; 5(1): 63-476.
Zehui Liu, Qian Hu, Wanyan Wang, Sisi Lu, Dang Wu, Shuyin Ze, Jiacheng He, Ying Huang, Wuyan Chen, Yechun Xu, Weiqiang Lu*, Jin Huang*. Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochem Pharmacol (Biochemical Pharmacology), 2020 Jul;177:114000
Zehui Liu, Wanyan Wang, Tingyu Huang, Cunfang Wang, Ying Huang*, Yong Tang*, Jin Huang*. CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer's disease. PLoS One, 2019 Sep 23, 14(9): e0222757.
Xueyuan Wu, Mingbo Wang, Yaqian Wang, Mengyin Li, Yilun Ying, Jin Huang*, Yitao Long*. Precise Construction and Tuning of an Aerolysin Single-Biomolecule Interface for Single-Molecule Sensing. CCS Chemistry. 2019 Aug; 1(3): 81-89.
Zhonghong Zhu, Qian Hu, Huiling Pan, Yuexing Zhang, Haibing Xu, Mohamedally Kurmoo, Jin Huang*, Ming-Hua Zeng*. Tracking the multiple-step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer. Science China-chemistry. 2019 Jun, 62(6): 719-726.
Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng*, Weiqiang Lu*, Jin Huang*. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018 Sep, 103(9): 1472-1483.
Li Lang, Qian Hu, Jingyuan Wang, Zehui Liu, Jin Huang*, Weiqiang Lu*, Ying Huang*. Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase. Chem Biol Drug Des (Chemical Biology & Drug Design). 2018 Jul, 92(1):1324-1332.
Weiqiang Lu, Feixiong Cheng, Wenzhong Yan, Xi Li, Xue Yao, Wenqiang Song, Mingyao Liu, Xu Shen, Hualiang Jiang, Jing Chen, Jian Li*, Jin Huang*.Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017, Aug 17, 36(33): 4719-4731.
Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng*, Jin Huang*. Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. J Med Chem (Journal of Medicinal Chemistry). 2017 Mar 9; 60(5): 1817-1828.
Jingyuan Wang, Xue Yao, Jin Huang*. New Tricks for Human Farnesyltransferase Inhibitor: Cancer and Beyond. MedChemComm, 2017, 8, 841-852.
Zengrui Wu, Weiqiang Lu, Dang Wu, Anqi Luo, Hanping Bian, Jie Li, Weihua Li, Guixia Liu, Jin Huang*, Feixiong Cheng*, Yun Tang*. In silico prediction of chemical mechanism-of-action via an improved network-based inference method. Br J Pharmacol (British Journal of Pharmacology). 2016 Sep 20;173:3372-3385.
Li Lang, Ningning Dong, Deyan Wu, Xue Yao, Weiqiang Lu*, Chen Zhang, Ping Ouyang, Jin Zhu, Yun Tang, Wei Wang, Jian Li*, Jin Huang*. 2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors. J Enzyme Inhib Med Chem (Journal of Enzyme Inhibition and Medicinal Chemistry). 2016 Sep 2; 31(sup4): 98-105.
Minghua Zeng*, Zheng Yin, Zehui Liu, Haibing Xu, Yingchun Feng, Yueqiao Hu, Lixian Chang, Yuexing Zhang, Jin Huang*, Mohamedally Kurmoo. Assembly of a Highly Stable Luminescent Zn5 Cluster and Application to Bio-Imaging. Angew Chem Int Ed Engl (Angewandte Chemie International Edition). 2016 Sep 12; 55(38): 11407-11411.
Xue Yao, Dang Wu, Ningning Dong, Ping Ouyang, Jiaqian Pu, Qian Hu, Jingyuan Wang, Weiqiang Lu*, Jin Huang*. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci (International Journal of Molecular Sciences). 2016 Jul 25; 17(8). pii: E1199.
Huiling Pan, Qian Hu, Jingyuan Wang, Zehui Liu, Dang Wu, Weiqiang Lu*, Jin Huang*. Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity. Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2016 Sep 2; 477(4): 915-922.
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