研究领域
1. 开展具有抗肿瘤生理活性的天然产物全合成;
2. 活性天然产物类似物的合成和构效关系研究;
近期论文
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Bu-Bing Zeng, Yikang Wu, Qian Yu, Yu-Lin Wu,etc. Enantiopure Simple Analogues of Annonaceous Acetogenins with Remarkable Selective Cytotoxicity towards Tumors Cell Lines, Angew. Chem. Int. Ed. 2001,1934-1937.
Sheng Jiang, Zhong-Hai Liu, Gang Shen, Bu-Bing Zeng, Xiao-guang Chen, Yu-Lin Wu, and Zhu-Jun Yao, Mimicry of Annonaceous Acetogenins: Enantioselective Synthesis of a (4R)-Hydroxy Analogue Having Potent Antitumor Activity. J. Org. Chem., 2002,3404-3408.
Bu-Bing Zeng, Bruce S. King Palladium-Catalyzed Synthesis of Water-Soluble Symmetric 9,10-Distituted Anthracenes, Synthesis, 2002, 2335-2337.
Bu-Bing Zeng, Yikang Wu, and Yu-Lin Wu, etc. Studies on Mimicry of Naturally Occurring Annonaceous Acetogenins: Non-THF Analogues Leading to Remarkable Selective Cytotoxicity against Human Tumor Cells. Chem. Eur. J., 2003,282-290.
Andrew D. Cohen, Bu-Bing Zeng, S. Bruce King, and John P. Toscano. Direct Observation of an Acyl Nitroso Species in Solution by Time-Resolved IR Spectrocopy. J. Am. Chem. Soc., 2003,1444-1445.
Bu-Bing Zeng, Jinming Huang, Marcus Wright and S. Bruce King, Synthesis and Evaluation of Water Soluble N-Hydrooxyurea derived Acyl Nitroso-9, 10-Dimethylanthracene Cycloadducts as Nitroxyl (HNO) Donors, Bioorg. & Med. Chem. Lett. 2004, 5565-5568.
Lee, A. M.; Ross, C. T.; Zeng, B.-B.; Singleton, S. F. A Molecular Target for Suppression of the Evolution of Antibiotic Resistance: Inhibition of the Escherichia coli RecA Protein by N6-(1-Naphthyl)-ADP. J. Med. Chem.; 2005; 5408-5411.
Leslie B. Poole, Bu-Bing Zeng, Sarah A. Knaggs, Mamudu Yakubu, and S. Bruce King, Synthesis of Chemical Probes to Map Sulfenic Acid Modifications on Proteins.Bioconjugate Chem., ASAP.
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