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1. 药物设计与合成 2. 有机小分子催化反应

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The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel. Toxicol. Lett. 2013, 219, 211?217. Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent. Bioorg. Med. Chem. Lett. 2012, 22, 958?962. Direct oxidative conversion of 3-aryl propionaldehydes to 3-aryl acroleins promoted by SOMO catalysis.Tetrahedron Lett. 2012, 53, 1207?1209. 1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: A novel cyclophilin A allosteric activator. Biochem. Biophy. Res. Commun. 2012, 425, 938?943. 2-(3,4-Dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio)acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation. Molecules. 2009, 14, 785?797. Refinement and 3D-QSAR studies of inhibitors of cyclophilin A containing amide linker. QSAR Comb. Sci. 2009, 28, 183?193. A direct amine-Palladium acetate cocatalyzed saegusa oxidation reaction of unmodified aldehydes to α,β-unsaturated aldehydes. Adv. Synth. Catal. 2009, 351, 1229?1232.

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