研究领域
(1)高分子纳米药物载体系统的设计与应用研究
应用高分子聚合反应理论和实验方法，制备出能满足小分子药物，蛋白质药物和基因药物需要的高分子载体系统，研究其在临床应用中对于药物的准确运输和按需释放问题。
(2)功能性聚合物微球的制备以及生物医用研究
进行分子结构设计，通过大分子自组装以及乳液聚合等实验方法制备荧光、温敏以及pH敏感等多种功能性的聚合物微球，研究其在抗体抗原的检测，特定分子的识别，生物传感器等方面的应用。
(3) 高分子表面图案化研究
通过纳米压印技术，构建高分子表面的图案，进一步进行材料的表面功能化，探讨其在生物医学领域中的应用。
(4)天然高分子的改性
通过对木质素、纤维素等天然高分子进行化学改性，提高其可加工性能研究。
近期论文
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Zhang Yan *Li Jinhong, Du Zhengzhen, Lang Meidong*Synthesis and pH-responsive assembly of methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) with pendant carboxyl groups. Journal of Polymer Science, Part A: Polymer Chemistry 52: 188-199, 2014.
Zhang Yan *, Liu Jianjing, Fu Yutong, Tan Ke, Ye Zhaoyang, Lang Meidong * Self-assembly of polyion complex nanocarriers from ammonium glycyrrhizinate and monomethoxy poly(ethylene glycol)-b- poly(γ-amino- ε-caprolactone) Journal of Materials Chemistry B,1(11): 1614-1621, 2013.
Zhang Yan *, Zhao Li, Lang Meidong*. Synthesis and properties of Pluronic-based pentablock copolymers with pendant amino groups Colloid &Polymer Science, 276: 769-775, 2013,
Zhang Yan *, Wang zhaojun, Zhou Weimin, Min Guoquan, Lang Meidong* Cationic poly(ε-caprolactone) surface functionalized mesoporous silica nanoparticles and their application in drug delivery. Applied Surface Science, 276:769-775, 2013.
Zhang Yan,Li Jiashi, Lang Meidong*,Tang Xiaolin, Li Lei, Shen Xizhong, Folate-functionalized nanoparticles for controlled 5-Fluorouracil delivery, Journal of Colloid and Interface Science, 354(1):202-209. 2011.
Zhang Qingchun, Tan Ke, Ye Zhaoyang, Zhang Yan * , Tan Wensong, Lang Meidong*. Preparation of open porous polycaprolactone microspheres and their applications as effective cell carriers in hydrogel system. Materials Science and Engineering C 32：2589-2595, 2012.
Zhang Qingchun, Zhang Yan *, Lang Meidong*. Mild Method for the Agglomeration of Dispersed Polycaprolactone Microspheres via a Genipin-Crosslinked Gelatin Hydrogel. Journal of Applied Polymer Science. 129(2):689-698,2012.
Zhang Qingchun, Jiang Yun , Zhang Yan *, Ye Zhaoyang , Tan Wensong, Lang Meidong *Effect of porosity on long-term degradation of poly (ε-caprolactone) scaffolds and their cellular response. Polymer Degradation and Stability, 98(1): 209-218, 2013.
Zhang Yi, Zhang Yan *, Chen Min, Yan Jinliang, Ye Zhaoyang, Zhou Yan, Tan Wen-song, Lang Meidong. Surface properties of amino-functionalized poly(-caprolactone) membranes and the improvement of human mesenchymal stem cell behavior. Journal of Colloid and Interface Science 368: 64-69, 2012.
Liu Jianjing, Zhang Yan*, Yan Jinliang, Lang Meidong, Synthesis and solution properties of pH responsive methoxy poly(ethylene glycol)-b-poly(γ-amino- ε-caprolactone), Journal of Materials Chemistry, 21 (18), 6677- 6682，2011.
Zeng Yue, Zhang Yan*, Lang Meidong, Synthesis and Characterization of Poly(ε-caprolactone-co-δ-valerolactone) with Pendant Carboxylic Functional Groups, Chinese Journal of Chemistry. 29:343-350. 2011
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