个人简介

B.S., Bowling Green State University, 1971 Ph.D., University of Wisconsin, Madison, 1975 Postdoctoral, Harvard University, 1975

研究领域

ORGANIC CHEMISTRY

Research in our group focuses heavily on the total synthesis of natural products, particularly those with desirable biological activity of some sort. Representative of the structures currently of interest to us are the cytotoxic macrodiolide swinholide (1), and bryostatin 1 (2), a complex macrolide that is showing exciting activity in clinical trials against a variety of human cancers.

近期论文

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Total Synthesis of Bryostatin 1 Gary E. Keck, Yam B. Poudel, Thomas J. Cummins, Arnab Rudra, and Jonathan A. Covel, J. Am. Chem. Soc.2011, 133, 744-747. The Synthetic Bryostatin Analog Merle 23 Dissects Distinct Mechanisms of Bryostatin Activity in the LNCaP Human Prostate Cancer Cell Line Noemi Kedei, Gabriella Czifra, Matthew B. Kraft, Anh P. Truong, Wei Li, Carina C. Sanchez, Gary E. Keck, and Peter M. Blumberg, Biochemical Pharmacology, 2011, 81, 1296-1308. Some Phorbol Esters May Partially Resemble Bryostatin 1 in Their Actions on LNCaP Prostate Cancer Cells and U937 Leukemia Cells Noemi Kedei, Emanuel Lubart, Nancy E. Lewin, Andrea Telek, Langston Lim, Poonam Mannam, Susan H. Garfield, Matthew B. Kraft, Gary E. Keck, Raz Jelinek, and Peter M. Blumberg, ChemBioChem.2011, 12, 1242-1251. Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1 Gary E. Keck, Yam B. Poudel, Arnab Rudra, Jeffrey C. Stephens, Noemi Kedei, Nancy E. Lewin, Megan L. Peach, and Peter M. Blumberg, Angew. Chemie Int. Ed.2010, 49, 4580?C4584. (PMID 20491108) The Bryostatin 1 A-Ring Acetate is Not the Critical Determinant for Antagonism of Phorbol Ester-Induced Biological Responses?? Gary E. Keck, Wei Li, Matthew B. Kraft, Noemi Kedei, Nancy E. Lewin, and Peter M. Blumberg, Org. Lett. 2009, 11, 2277-2280. (PMID: 19419164) Substitution on the A Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters?? Gary E. Keck, Yam B. Poudel, Dennie S. Welch, Matthew B. Kraft, Anh P. Truong, Jeffrey C. Stephens, Noemi Kedei, Nancy E. Lewin, and Peter M. Blumberg, Org. Lett.2009, 11, 593-596. Diastereoselective Synthesis of Cyclopentapyridazinones via Radical Cyclization: Synthetic Studies Toward Halichlorine?? Gary E. Keck and Stacey A. Heumann, Org. Lett. 2008, 10, 4783-4786. Total Synthesis of Epothilones B and D: Stannane Equivalents for ??-Keto Ester Dianions?? Gary E. Keck, Robert L. Giles, Victor J. Cee, Carrie A. Wager, Tao Yu, and Matthew B. Kraft, J. Org. Chem.2008, 73, 9675-9691. "ent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes that Mimic Phorbol Ester Function" Gary E. Keck, Matthew B. Kraft, Anh P. Truong, Wei Li, Carina C. Sanchez, Noemi Kedei, Nancy Lewin, and Peter M. Blumberg, J. Am. Chem. Soc. 2008, 130, 6660-6661. A New Construction of 2-Alkoxypyrans by an Acylation-Reductive Cyclization Sequence?? Lars V. Heumann and Gary E. Keck, Org. Lett. 2007, 9, 1951-1954. "nthetic Studies Toward Bryostatin 1: Preparation of a C1?CC16 Fragment by Pyran Annulation" G. E. Keck, D. S. Welch, and Y. B. Poudel, Tetrahedron Lett. 2006, 47, 8267-8270. "Synthetic Studies Toward the Bryostatins: A Substrate-Controlled Approach to the A-Ring", G. E. Keck, D. S. Welch, and P. K. Vivian, Org. Lett. 2006, 8, 3667-3670. "Total Synthesis of (+)-Dactylolide", C. C. Sanchez and G. E. Keck, Org. Lett. 2005,7, 3053-3056. "Synthetic Studies on the Bryostatins: Synthetic Routes to Analogues Containing the Tricyclic Macrolactone Core", G. E. Keck and A.P. Truong, Org. Lett. 2005, 7, 2153-2156. Pyran Annulation: Asymmetric Synthesis of 2,6-Disubstituted-4-methylene Tetrahydropyrans??, Gary E. Keck, Jonathan A. Covel, Tobias Schiff, and Tao Yu, Org. Lett.2002, 4, 1189-1192