个人简介

B.S., Second Military Medical University, China, 1994 Ph.D., Second Military Medical University, China, 1999 Postdoctoral fellow, Northwestern University, 2002-2006 Research Associate Professor, Northwestern University, 2007-2010

研究领域

ORGANIC & BIOORGANIC CHEMISTRY

Research interests in our laboratory lie at the interface of chemistry and biology. We mainly focus on structure-based design and synthesis of small molecules that can modulate cellular signaling pathways with an emphasis on protein-protein interactions and target specificity. Technique cores in our laboratory are fragment-based screening and de novo design, the design and synthesis of versatile fragment building blocks from natural products, and construction of fragment libraries to explore isozyme selectivity. Specific areas of interest include: (1) Development of new chemistry-oriented techniques to design highly selective small-molecule inhibitors for protein?Cprotein interactions; (2) Development of rational approaches for small-molecule allosteric inhibition of protein?Cprotein interactions; (3) Incorporation of natural product building blocks into peptides for the regulation of protein?Cprotein interactions. Our long-term goal of this study is the systematic data mining of natural product building blocks and the study of their ability as ve

近期论文

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Huang, Z.; Zhang, M.; Burton, S. D.; Katsakhyan, L. N.; Ji, H. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt ?-catenin/T-cell factor proteinprotein interactions. ACS Chem. Biol.2014, 9(1), 193201. Zhang, M.; Catrow, J. L.; Ji, H. High-throughput selectivity assays for small-molecule inhibitors of ?-catenin/T-cell factor proteinprotein interactions. ACS Med. Chem. Lett.2013, 4(2), 306-311. Yu, B.; Huang, Z.; Dillard, D. R.; Ji, H. Rational design of small-molecule beta-catenin/T-cell factor inhibitors by bioisostere replacement. ACS Chem. Biol.2013, 8(3), 524-529. Zhang, M.; Huang, Z.; Yu, B.; Ji, H. New homogeneous high-throughput assays for inhibitors of ?-catenin/Tcf protein-protein interactions. Anal. Biochem.2012, 424(1), 57-63. Huang, H.; Ji, H.; Li, H.; Jing, Q.; Labby, K. J.; Mart?sek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. J. Am. Chem. Soc.2012, 134(28), 11559-11572. Ji, H.; Delker, S. L.; Li, H.; Mart?sek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives. J. Med. Chem.2010, 53(21), 7804-7824. Delker, S. L.; Ji, H.; Li, H.; Jamal, J.; Fang, J.; Xue, F.; Silverman, R. B.; Poulos, T. L. Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model. J. Am. Chem. Soc.2010, 132(15), 5437-5442. Ji, H.; Tan, S.; Igarashi, J.; Li, H.; Derrick, M.; Mart??sek, P.; Roman, L. J.; V??squez-Vivar, J.; Poulos, T. L.; Silverman, R. B. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann. Neurol.2009, 65(2), 209-217. Ji, H.; Li, H.; Mart??sek, P.; Roman, L. J.; Poulos, T. L.; Silverman, R. B. Discovery of highly potent and selective inhibitors of neuronal nitric