个人简介

B.S., University of California, Irvine, 2000 Ph.D., University of Illinois at Urbana-Champaign, 2005 Postdoctoral Fellow, Harvard University, 2007-2010

研究领域

ORGANIC & BIOLOGICAL CHEMISTRY

Nature utilizes specific interactions between nucleic acids, proteins, and small molecules to direct all of the biological processes that make life possible. Inspired by these molecular recognition capabilities, the aim of our research program is twofold: (1) to engage in hypothesis driven research towards a deeper understanding of the forces that drive small molecule-nucleic acid and nucleic acid-nucleic acid interactions (2) to apply our understanding of these interactions towards the development of new technologies in biosensing, bioimaging, and antisense therapeutics.

近期论文

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Feagin, T. A.; Olsen, D. P. V.; Headman, Z. C.; Heemstra, J. M. High-Throughput Enantiopurity Analysis using Enantiomeric DNA-Based Sensors. J. Am. Chem. Soc. 2015, just accepted manuscript. Kent, A. D.; Spiropulos, N. G.; Heemstra, J. M. General Approach for Engineering Small-Molecule-Binding DNA Split Aptamers. Anal. Chem.2013, 85, 9916-9923. De Costa, N. T. S.; Heemstra, J. M. Evaluating the Effect of Ionic Strength on Duplex Stability for PNA Having Negatively or Positively Charged Side Chains. PLoS ONE2013, 8, e58670. Spiropulos, N. G.; Heemstra, J. M. Templating Effect in DNA Proximity Ligation Enables use of Non-Bioorthogonal Chemistry in Biological Fluids. Artificial DNA: PNA & XNA2012, 3, 123-128. Feagin, T. A.; Shah, N. I.; Heemstra, J. M. Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone. J. Nucleic Acids.2012, 2012, 354549. Sharma, A. K.; Kent, A. D.; Heemstra, J. M. Enzyme-Linked Small-Molecule Detection using Split Aptamer Ligation. Anal. Chem.2012, 84, 6104-6109. Sharma, A. K.; Heemstra, J. M. Small Molecule-Dependent Split Aptamer Ligation. J. Am. Chem. Soc. 2011, 133, 12426-12429. Heemstra, J. M.; Liu, D. R. Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions. J. Am. Chem. Soc. 2009, 131, 11347-11349. Kowtoniuk, W. E.; Shen, Y.; Heemstra, J. M.; Agarwal, I.; Liu, D. R. A chemical screen for biological small molecule?CRNA conjugates reveals CoA-linked RNA. Proc. Nat. Acad. Sci. U.S.A. 2009, 106, 7768-7773. Heemstra, J. M.; Kerrigan, S. A.; Doerge, D. R.; Helferich, W. G.; Boulanger, W. A. Total Synthesis of (S)-Equol. Org. Lett. 2006, 8, 5441-5443. Heemstra, J. M.; Moore, J. S. Enhanced Methylation Rate within a Foldable Molecular Receptor. J. Org. Chem. 2004, 69, 9234-9237. Heemstra, J. M.; Moore, J. S. Helix stabilization through pyridinium-pi interactions. Chem. Commun. 2004, 1480-1481. Heemstra, J. M.; Moore, J. S. A novel indicator series for measuring pKa values in acetonitrile. Tetrahedron2004, 60, 7287-7292. Goto, H.; Heemstra, J. M.; Hill, D. J.; Moore, J. S. Single-Site Modifications and Their Effect on the Folding Stabili