Arnold, Edward - Rutgers University - Department of Chemistry and Chemical Biology

个人简介

Ph.D. Cornell University, 1982

研究领域

Crystallographic studies of human viruses and viral proteins, molecular design

近期论文

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Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel Kang, D., Ruiz, F. X., Feng, D., Pilch, A., Zhao, T., Wei, F., Wang, Z., Sun, Y., Fang, Z., De Clercq, E., Pannecouque, C., Arnold, E., Liu, X. & Zhan, P., Feb 13 2020, In : Journal of medicinal chemistry. 63, 3, p. 1298-1312 15 p. Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance Xavier RUIZ, F. & Arnold, E., Apr 2020, In : Current Opinion in Structural Biology. 61, p. 113-123 11 p. Alpha-carboxynucleoside phosphonates: Direct-acting inhibitors of viral DNA polymerases Balzarini, J., Ford, A., Maguire, N. M., John, J., Das, K., Arnold, E., Dehaen, W. & Maguire, A., Jan 2019, In : Future Medicinal Chemistry. 11, 2, p. 137-154 18 p. Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease Sagong, H. Y., Bauman, J. D., Nogales, A., Martínez-Sobrido, L., Arnold, E. & LaVoie, E. J., Jun 18 2019, In : ChemMedChem. 14, 12, p. 1204-1223 20 p. Epistasis and entrenchment of drug resistance in HIV-1 subtype B Biswas, A., Haldane, A., Arnold, E. & Levy, R. M., Oct 2019, In : eLife. 8, e50524. Michael G. Rossmann (1930-2019)Wu, H. & Arnold, E., Aug 1 2019, In : Nature structural & molecular biology. 26, 8, p. 660-662 3 p. Michael G. Rossmann (1930-2019), pioneer in macromolecular and virus crystallography: scientist, mentor and friend Arnold, E., Wu, H. & Johnson, J. E., Jun 1 2019, In : Acta crystallographica. Section D, Structural biology. 75, p. 523-527 5 p. Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1 Ruiz, F. X., Hoang, A., Das, K. & Arnold, E., Nov 14 2019, In : Journal of medicinal chemistry. 62, 21, p. 9996-10002 7 p. Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes Martinez, S. E., Bauman, J. D., Das, K. & Arnold, E., Mar 2019, In : Protein Science. 28, 3, p. 587-597 11 p. Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation Das, K., Martinez, S. E., DeStefano, J. J. & Arnold, E., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7308-7313 6 p. Developing and evaluating inhibitors against the RNase H active site of HIV-1 reverse transcriptase Boyer, P. L., Smith, S. J., Zhao, X. Z., Das, K., Gruber, K., Arnold, E., Burke, T. R. & Hughes, S. H., Jul 1 2018, In : Journal of virology. 92, 13, e02203-17. Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae (Scientific Reports (2018) DOI: 10.1038/s41598-018-23423-1) Vedithi, S. C., Malhotra, S., Das, M., Daniel, S., Kishore, N., George, A., Arumugam, S., Rajan, L., Ebenezer, M., Ascher, D. B., Arnold, E. & Blundell, T. L., Dec 1 2018, In : Scientific reports. 8, 1, 8250. Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae Vedithi, S. C., Malhotra, S., Das, M., Daniel, S., Kishore, N., George, A., Arumugam, S., Rajan, L., Ebenezer, M., Ascher, D. B., Arnold, E. & Blundell, T. L., Dec 1 2018, In : Scientific reports. 8, 1, 5016. Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses Balzarini, J., Menni, M., Das, K., van Berckelaer, L., Ford, A., Maguire, N. M., Liekens, S., Boehmer, P. E., Arnold, E., Götte, M. & Maguire, A. R., Jul 15 2017, In : Biochemical Pharmacology. 136, p. 51-61 11 p. Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition Lin, W., Mandal, S., Degen, D., Liu, Y., Ebright, Y. W., Li, S., Feng, Y., Zhang, Y., Mandal, S., Jiang, Y., Liu, S., Gigliotti, M., Talaue, M., Connell, N., Das, K., Arnold, E. & Ebright, R. H., Apr 20 2017, In : Molecular cell. 66, 2, p. 169-179.e8 Structural Insights into HIV reverse transcriptase mutations Q151m and Q151m complex that confer multinucleoside drug resistance Das, K., Martinez, S. E. & Arnold, E., Jun 2017, In : Antimicrobial agents and chemotherapy. 61, 6, e00224-17. A new class of allosteric HIV-1 integrase inhibitors identified by crystallographic fragment screening of the catalytic core domain Patel, D., Antwi, J., Koneru, P. C., Serrao, E., Forli, S., Kessl, J. J., Feng, L., Deng, N., Levy, R. M., Fuchs, J. R., Olson, A. J., Engelman, A. N., Bauman, J. D., Kvaratskhelia, M. & Arnold, E., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23569-23577 9 p. Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis - Binding of Foscarnet Das, K., Balzarini, J., Miller, M. T., Maguire, A. R., DeStefano, J. J. & Arnold, E., Aug 19 2016, In : ACS chemical biology. 11, 8, p. 2158-2164 7 p. Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates Mullins, N. D., Maguire, N. M., Ford, A., Das, K., Arnold, E., Balzarini, J. & Maguire, A. R., Jan 1 2016, In : Organic and Biomolecular Chemistry. 14, 8, p. 2454-2465 12 p. Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries Neogi, U., Häggblom, A., Singh, K., Rogers, L. C., Rao, S. D., Amogne, W., Schülter, E., Zazzi, M., Arnold, E., Sarafianos, S. G. & Sönnerborg, A., Feb 1 2016, In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 367-371 5 p.