刘润辉 - 华东理工大学 - 材料科学与工程学院

个人简介

2004-2009 美国普渡大学(Purdue University) 博士 2009-2010 美国加州理工学院(California Institute of Technology) 博士后 2010-2014 美国威斯康星大学麦迪逊校区(University of Wisconsin-Madison) 博士后

研究领域

模拟天然蛋白功能的合成高分子生物材料，包括 1. 功能化聚合物单体的合成；多功能高分子材料的制备及合成方法研究 2. 生物相容、生物可降解高分子材料的研究与开发 3. 抗细菌、抗真菌生物材料的研制与作用机理研究 4. 具有细胞黏附、细胞选择功能的生物材料研究及在组织修复中的应用 5. 抗非特异性蛋白吸附及微生物生物膜形成的防污材料研究及在生物医学工程领域的应用 6. 蛋白类及小分子药物的体内传输和可控释放研究 7. 抗肿瘤多肽研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Chen, Q.; Zhang D.; ZhangW.; Zhang H.; Zou J.; ChenM.; LiJ.; Yuan Y.; Liu, R.*Dual mechanismβ-amino acid polymers promoting cell adhesion.Nature Communications 2021, 12, 562 Zhang, D.; Chen, Q.; Shi, C.; Chen, M.; Ma, K.; Wan, J.; Liu, R.* Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials. Adv. Funct. Mater. DOI: 10.1002/adfm.202007226. Etayash, H.; Qian, Y.; Pletzer, D.; Zhang, Q.; Xie, J.; Cui, R.; Dai, C.; Ma, P.; Qi, F.; Liu, R.* Hancock, R. E. W.* Host Defense Peptide-Mimicking Amphiphilic beta-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity. J. Med. Chem. 2020, 63, 12921-12928. Zhang, D.; Chen, Q.; Zhang, W.; Liu, H.; Wan, J.; Qian, Y.; Li, B.; Tang, S.; Liu, Y.; Chen, S.; Liu, R.* Silk‐inspired β‐peptide Materials Resist Fouling and the Foreign‐body Response. Angew. Chem. Int. Ed. 2020, 59, 9586–9593. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-beta-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020,59, 7240-7244. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2‐Oxazoline) Based Functional Mimics of Peptides to Eradicate MRSA Infections and Persisters While Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412-6419. Chen, Q.; Yu, S.; Zhang, D.; Zhang, W.; Zhang, H.; Zou, J.; Mao, Z.; Yuan, Y.; Gao C.; Liu, R.*, Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors. J. Am. Chem. Soc. 2019, 141, 16772 Wu, Y.; Zhang, D.; Ma, P.; Zhou, R.; Hua, L.; Liu, R.*, Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides. Nat. Commun. 2018, 9 (1), 5297. Ding, X.; Duan, S.; Ding, X.; Liu, R.*; Xu, F.*, Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens. Adv. Funct. Mater. 2018, 28 (40), 19. Qi. F; Qian, Y.; Shao, N.; Zhou, R.; Zhang, S.; Lu Z.; Zhou, M.; Xie, J.; Wei, T.; Yu, Q.;, Liu, R., Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers. ACS Appl. Mater. Interfaces 2019, 11 (21), 18907-18913. Qian, Y.; Qi, F.; Chen, Q.; Zhang, Q.; Qiao, Z.; Zhang, S.; Wei, T.; Yu, Q.; Yu, S.; Mao, Z.; Gao, C.; Ding, Y.; Cheng, Y.; Jin, C.; Xie, H.; Liu, R.*, Surface Modified with a Host Defense Peptide-Mimicking beta-Peptide Polymer Kills Bacteria on Contact with High Efficacy. ACS Appl. Mater. Interfaces 2018, 10 (18), 15395-15400. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms” J. Am. Chem. Soc. 2015, 137: 2183-2196. Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc. 2014, 136: 4333-4342. Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc. 2014, 136: 4410-4418. Liu, R.#; Suárez, J. M.#; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (equal contribution) Chakraborty, S.#; Liu, R.#; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc. 2014, 136, 14530-14535. (equal contribution) Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”, J. Am. Chem. Soc. 2013, 135: 16296-16299. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273. Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751. Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.