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研究领域

1、 基于树状大分子的纳米医学: a. 有机/无机纳米复合材料的合成及其在肿瘤分子影像诊断(CT和MRI)中的应用; b. 纳米药物输送体系的制备与抗肿瘤效果评价; c. 有机/无机杂化纳米颗粒用于基因传递的研究。 2、静电纺纳米纤维材料在生物医学与环境科学中的应用。

近期论文

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1. Xiangyang Shi,* Mingwu Shen, Helmuth Moehwald. Polyelectrolyte multilayer nanoreactors toward the synthesis of diverse nanostructured materials. Invited review. Prog. Polym. Sci. 2004, 29, 987-1019. (Impact factor 22.870) 2. Mahasin S. Mujahid, Ana V. Diez Roux, Mingwu Shen et al. Relation between Neighborhood Environments and Obesity in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2008, 167(11): 1349-1357 (Impact Factor 5.744 ). 3. Mingwu Shen, Su He Wang, Xiangyang Shi, Qingguo Huang , Elijah J. Petersen, Roger A. Pinto, James R. Baker, Jr., and Walter J. Weber, Jr.. Polyethyleneimine-Mediated Functionalization of Multi-Walled Carbon Nanotubes: Synthesis, Characterization, and in vitro Toxicity Assay. J. Phys. Chem. C 2009, 113(8), 3150-3156 (impact factor 4.519). 4. Auchincloss AH, Diez Roux AV, Mujahid MS, Shen M, Bertoni AG, Carnethon MR. Neighborhood resources for physical activity and healthy foods and incidence of type 2 diabetes (the Multi-Ethnic Study of Atherosclerosis). Archives of Internal Medicine. 2009, 12;169(18): 1698-704. (impact factor 10.63) 5. Xiangyang Shi, Su He Wang, Mingwu Shen, Mary E. Antwerp, Xisui Chen, Chang Li, Elijah J. Petersen, Qingguo Huang, Walter J. Weber, Jr., and James R. Baker, Jr. Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes: Synthesis, Characterization, and in vitro Cancer Cell Targeting and Imaging. Biomacromolecules 2009, 10, 1744-1750 (impact factor 5.324). 6. Xiangyang Shi, Su He Wang, Inhan Lee, Mingwu Shen, and James R. Baker, Jr. Comparison of the Internalization of Targeted Dendrimers and Dendrimer- Entrapped Gold Nanoparticles into Cancer Cells. Biopolymers 2009, 91, 936-942 (impact factor 2.605). 7. Mingwu Shen, Xiangyang Shi. Capillary Electrophoresis of Dendrimer-Related Medical Nanodevices. In Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing. Shayne C. Gad, Eds; John Wiley and Sons, 2010, 1–28. 8. Mingwu Shen and Xiangyang Shi. Dendrimer-based organic/inorganic hybrid nanoparticles in biomedical applications. Nanoscale 2010, 2, 1596–1610 (impact factor 4.109). 9. Mingwu Shen, Kai Sun, Xiangyang Shi. Hydroxylated dendrimer-stabilized gold and silver nanoparticles: Spontaneous formation, characterization, and properties. Curr. Nanosci. 2010, 6, 307-314 (impact factor 1.879). 10. Hui Liu, Han Wang, Rui Guo, Xueyan Cao, Jinglong Zhao, Yu Luo, Mingwu Shen, Guixiang Zhang, and Xiangyang Shi. Size-controlled synthesis of dendrimer-stabilized silver nanoparticles for X-ray computed tomography imaging applications. Polym. Chem. 2010, 1 (10), 1677 - 1683. 11. Xiangyang Shi, Inhan Lee, Xisui Chen, Mingwu Shen, Shili Xiao, Meifang Zhu, and James R. Baker, Jr., Su He Wang. Influence of dendrimer surface charge on the bioactivity of 2-methoxyestradiol complexed with dendrimers. Soft Matter 2010, 6, 2539–2545 (impact factor 4.869). 12. Rui Guo, Han Wang, Chen Peng, Mingwu Shen, Minjie Pan, Xueyan Cao, Guixiang Zhang, Xiangyang Shi. X-Ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles. J. Phys. Chem. C 2010, 114(1), 50-56 (impact factor 4.519). 13. Yin Wang, Rui Guo, Xueyan Cao, Mingwu Shen, and Xiangyang Shi. Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. Biomaterials 2011, 32, 3322-3329 (impact factor 7.882). 14. O'Neill, MS; Diez-Roux, AV; Auchincloss, AH; Shen, M; Lima, JA; Polak, JF; Barr, RG; Kaufman, J; Jacobs, DR. Long-Term Exposure to Airborne Particles and Arterial Stiffness: The Multi-Ethnic Study of Atherosclerosis (MESA). Environmental health perspectives, 2011; 119(6), 844-51 (citation #1, impact factor 6.087). 15. Han Wang, Linfeng Zheng, Chen Peng, Rui Guo, Mingwu Shen, Xiangyang Shi, Guixiang Zhang. Computed Tomography Imaging Of Cancer Cells Using Acetylated Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2011, 32, 2979-2988 (impact factor 7.882). 16. Rui Guo, Han Wang, Chen Peng, Mingwu Shen, Guixiang Zhang, Xiangyang Shi. Enhanced X-Ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles Complexed with Diatrizoic Acid. J. Mater. Chem. 2011, 21 (13), 5120 - 5127 (impact factor 5.099). 17. Chen Peng, Han Wang, Rui Guo, Mingwu Shen, Xueyan Cao, Meifang Zhu, Guixiang Zhang, and Xiangyang Shi. Acetylation of Dendrimer-Entrapped Gold Nanoparticles: Synthesis, Stability, and X-ray Attenuation Property. J. Appl. Polym. Sci. 2011, 119(3), 1673-1682 (impact factor 1.203). 18. Xueyan Cao, Jingjing Chen, Shihui Wen, Chen Peng, Mingwu Shen, and Xiangyang Shi*. Effect of Surface Charge of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the Improvement of Polymerase Chain Reaction. Nanoscale 2011, 3 (4), 1741-1747. (impact factor 4.109) 19. Yin Wang, Xueyan Cao, Rui Guo, Mingwu Shen, Mengen Zhang, Meifang Zhu, and Xiangyang Shi*. Targeted delivery of doxorubicin into cancer cells using a folic acid-dendrimer conjugate. Polym. Chem. 2011, 2(8), 1754-1760. 20. Mengen Zhang, Rui Guo, Yin Wang, Xueyan Cao, Mingwu Shen, and Xiangyang Shi*. Multifunctional Dendrimer/Combretastatin A4 Inclusion Complexes Enable in Vitro Targeted Cancer Therapy. Int. J. Nanomed., 2011, 6, 2337-2349 (impact factor 4.976).

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