个人简介

B. A. University of Colorado, 1975 Ph. D. Cornell University, 1982 NSF-CNRS Postdoctoral Fellow, Universit?? Louis Pasteur, Strasbourg 1981-83

研究领域

ORGANIC & BIOLOGICAL CHEMISTRY

Nucleic acid chemistry with a focus on chemical modifications to DNA and RNA bases forms the core of our program. In DNA, such modifications are typically deleterious leading to mutations, genetic diseases and cancer; however, altered bases in RNA are of interest to help explain the role of RNA in the origin and evolution of life, specifically primitive metabolic processes on early Earth. These studies also help us understand how to modify nucleic acids to alter the function of DNA or RNA in the cell, or to analyze nucleic acids extracted from cells. Members of the lab include organic, biological, analytical and inorganic chemists.

近期论文

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Y. Ye, B. H. Munk, J. G. Muller, A. Cogbill, C. J. Burrows, and H. B. Schlegel,  Mechanistic and kinetic aspects of the formation of guanidinohydantoin and spiroiminodihydantoin under acid conditions, Chem. Res. Toxicol.2009, 22, 526-535. S. D. Kathe, R. Barrantes-Reynolds, P. Jarugal, M. R. Newton, C. J. Burrows, V. Bandaru, M. Dizdaroglu, J. P. Bond, and S. S. Wallace, Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases, DNA Repair 2009, 8, 643-653. T. Markus, S. Daube, R. Naaman, A. M. Fleming, J. G. Muller, C. J. Burrows, The electronic structure of DNA: The unique properties of 8-oxoguanosine, J. Am. Chem. Soc. 2009, 131, 89-95. C. J. Burrows, Surviving an Oxygen Atmosphere: DNA Damage and Repair, in Chemical Evolution II: From Origins of Life to Modern Society, Zaikowski, L.; Friedrich, J. M.; Seidel, S. R.; Eds. ACS Symposium Series, Washington, DC, 2009, in press. X. Xu, A. Fleming, J. G. Muller, and C. J. Burrows, Formation of Tricyclic [4.3.3.0] Adducts Between 8-Oxoguanosine and Tyrosine under Conditions of Oxidative DNA-Protein Cross-linking,?? J. Am. Chem. Soc. 2008, 130, 10080-10081. N. Krishnamurthy, X. Zhao, C. J. Burrows, and S. S. David, ??Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1,?? Biochemistry2008, 47, 7137-7146. X. Xu, J. G. Muller, Y. Ye and C. J. Burrows, ??DNA-protein cross-links between guanine an"ine depend on the mechanism of oxidation for formation of C5 vs. C8 adducts,?? J. Am. Chem. Soc. 2008, 130, 703-709. B. H. Munk, C. J. Burrows, and H. B. Schlegel, ??An exploration of mechanisms for the transformation of 8-oxoguanine to guanidinohydantoin and spiroiminodihydantoin by density functional theory,?? J. Am. Chem. Soc. 2008, 130, 5245-5256. V. Bandaru, X. Zhao, M. R. Newton, C. J. Burrows, and S. S. Wallace, ??Human Endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus,?? DNA Repair 2007, 6, 1629-1641. N. Krishnamurthy, J. G. Muller, C. J. Burrows, and S. S. David, ??Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli Fpg,?? Biochemistry2007, 46, 9355-9365. B. H. Munk, C. J. Burrows, and H. B. Schlegel, ??An exploration of mechanisms for the transformation of