研究领域
（1）具有潜在生物活性的天然产物的结构修饰与生物活性研究。主要集中在4-羟基-2-吡啶酮类天然生物碱冬青生菌素H（Ilicicolin H）和双吲哚吡咯类天然生物碱莱那霉素B（Lynamicin B）等的结构优化以及抗菌、抗真菌和抗肿瘤等生物活性研究。
（2）心脑血管疾病、抗肿瘤以及眼科用药等重大疾病治疗药物的仿制与新药申报。
近期论文
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[1] Yulong An, Yunxia, Deng, Wei Zhang, Shengyin, Zhao*. Regioselective hetero-Michael addition of oxygen.Sulfur, and nitrogen nuclophiles to maleimides catalyzed BF3.OEt2. Synthesis, 2015, published online on March 5, DOI:10.1055/s-0034-1380404.
[2] Shengyin Zhao*, Biaoshuo Liu, Jing Huang, Shaohua Cheng, Yunxia Deng, ZhiyuShao.Thermal-induced dimerization cyclization of ethyl N-(styrylcarbamoyl)acetates: formation of 4-hydroxy-2(1H)-pyridone-3- carboxamidederivaives. Synthetic Communication, 2014, 44(14):2066-2075
[3] Yulong An, Zhiyu Shao, Jian Cheng, Shengyin Zhao*. Highly efficient aluminum trichloride catalyzed Michael addition of indoles and pyrroles to maleimides, Synthesis, 2013, 45(19): 2719-2726
[4] Hongmin Ma, Qiang Zhou, Yumin Tang, Zhuan Zhang, Yongsheng Chen, Haiyan He, Haixue Pan, Mancheng Tang, JufangGao, Shengyin Zhao, Yasuhiro Igarashi, Gongli Tang*. Unconventional origin and hybrid system for construction of pyrrolopyrrole moiety in Kinostatin biosynthesis. Chemistry & Biology, 2013, 20(6):796-805
[5] 李慧,周强,唐玉敏,赵圣印*,唐功利*. 越野他汀生物合成介导的海洋小单胞菌中一个新天然产物的发现, 有机化学, 2013, 33(6):1326-1332.
[6] Shengyin Zhao*, Haiquan Zhang, Dengqing Zhang, Zhiyu Shao. N-methylation of NH-containing heterocycles with dimethyl carbonate catalyzed by TMEDA. Synthetic Communication.2012, 42(1): 128-135.
[7]Shengyin Zhao*, Yanwu Yang, Haiquan Zhang, Yue Yun, Mei Fan.Synthesis and cytotoxicity of novel 3-amino-4-indolylmaleimides. Archive of Pharmacal Research, 2011, 34(4):519-526.
[8] Hongyu Liang, Dengqing Zhang,Yu Yue, Zhe shi, Shengyin Zhao*. Synthesis and biological activity of some 1,3-dihydro-2H-3-benzazepin-2-ones with piperazine moiety as bradycardic agents. Archiv Der Pharmazie-Chemistry in Life Science, 2010, 343(2):114-119
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