个人简介
王杰男博导中国科学院武汉物理与数学研究所
教育背景
2007-10--2009-09耶鲁大学生物医学工程系联合培养博士
2004-09--2009-06兰州大学化学化工学院分析化学专业研究生博士
2000-09--2004-06兰州大学化学化工学院学士
学历
2004-2009兰州大学与耶鲁大学联合培养博士分析化学/生物医学工程导师:胡之德/GraemeF.Mason
2000-2004兰州大学化学化工学院化学学士
学位
博士
工作经历
2017.10中国科学院武汉物理与数学研究所脑科学研究中心研究员
2012.10中国科学院武汉物理与数学研究所磁共振应用部副研究员
2009.12中国科学院武汉物理与数学研究所磁共振应用部助理研究员
2010.10-2013.3美国耶鲁大学放射诊断系博士后
工作简历
2017-10~现在,中国科学院武汉物理与数学研究所,研究员
2012-10~2017-10,中国科学院武汉物理与数学研究所,副研究员
2010-10~2013-03,耶鲁大学放射诊断系,博士后合作研究
2009-12~2012-10,中国科学院武汉物理与数学研究所,助理研究员
教授课程
波谱与影像数据分析
专利与奖励
奖励信息
(1)第十七届国际磁共振生命会议优秀青年科学家奖,一等奖,其他,2016
专利成果
(1)一种简易新型实验用麻醉机,发明,2014,第1作者,专利号:201410534309.9
(2)一种核磁共振波谱谱峰对齐及谱峰提取方法,发明,2014,第1作者,专利号:201410764523.3
(3)脊髓功能核磁共振信号分析软件[简称:SpinAnal]V1.0,发明,2018,第1作者,专利号:2018SR087058
(4)磁共振成像T2弛豫时间计算软件[简称:T2Cal],发明,2018,第1作者,专利号:2018SR186113
(5)荧光磁共振成像协同分析软件[简称:Fluo-MRIAnal]V1.0,发明,2017,第1作者,专利号:2017SR075582
(6)质谱谱峰配对分析软件[简称:MsPeakMatch]V1.0,发明,2016,第1作者,专利号:2017SR075522
科研项目
(1)活体动物大脑中能量代谢和神经传递动力学参数的定量测定方法,主持,国家级,2012-01--2014-12
(2)基于脑网络研究脑内长期乙醛蓄积诱发脑损伤的多层次表征,主持,国家级,2018-01--2021-12
(3)新型降压药物研发及其疗效的多模态磁共振成像评估,主持,市地级,2018-01--2019-12
(4)第三届全国神经环路示踪技术培训班,主持,部委级,2018-01--2018-12
(5)活体脑多光子显微结构与功能成像关键技术研究,参与,国家级,2015-01--2017-12
(6)光遗传技术在情感和记忆神经回路调控研究中的应用,参与,国家级,2012-01--2015-12
(7)气味相关的两个大脑半球之间的联系,参与,国家级,2016-10--2019-09
(8)神经回路结构研究新技术新方法及其应用,参与,部委级,2012-01--2017-06
(9)第四届神经环路技术高级培训班,主持,部委级,2019-01--2019-12
参与会议
(1)AcuteandChronicEnergeticEffectsofAlocholontheBrainJieWang,LihongJiang,GraemeF.Mason2013-02-16
(2)Anethanolvaporchamberforsmallanimals1.JieWang,LihongJiang,HongyingDu,GraemeF.Mason2012-06-24
(3)Metabolicproductsof[1-13C]ethanolintheawakeratbrain2.JieWang,PeterC.Nicholas,DanielKim,XiaoxianMa,Ting-KaiLi,JeffreyM.Macdonald,FultonT.Crews,GraemeMason2012-06-24
近期论文
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(1)Effectofmyocardialischemicpreconditioningonischemia-reperfusionstimulation-inducedactivationinratthoracicspinalcordwithfunctionalMRI,InternationalJournalofCardiology,2019,第1作者
(2)ComprehensiveProfilingofFecalMetabolomeofMicebyIntegratedChemicalIsotopeLabeling-MassSpectrometryAnalysis,AnalyticalChemistry,2018,第6作者
(3)EvaluationofmetabolitesextractionstrategiesforidentifyingdifferentbrainregionsandtheirrelationshipwithalcoholpreferenceandgenderdifferenceusingNMRmetabolomics,Talanta,2018,第1作者
(4)Fluorescenceself-quenchingassayforthedetectionoftargetcollagensequencesusingashortprobepeptide,Talanta,2018,第5作者
(5)1HNMR-basedmetabolomicsfordiscriminationofricefromdifferentgeographicaloriginsofChina,JournalofCerealScience,2017,第2作者
(6)CorrectingmiR92a-vGAT-MediatedGABAergicDysfunctionsRescuesHumanTau-InducedAnxietyinMice,MolTher,2017,其他(合作组作者)
(7)ReducedGABAergictransmissionintheventrobasalthalamuscontributestothermalhyperalgesiainchronicinflammatorypain,SciRep-Uk,2017,第4作者
(8)Whole-BrainMappingoftheInputsandOutputsoftheMedialPartoftheOlfactoryTubercle,FrontNeuralCircuit,2017,第7作者
(9)WS2andMoS2biosensingplatformsusingpeptidesasprobebiomolecules,SciRep-Uk,2017,第6作者
(10)Fluorescenceself-quenchingassayforthedetectionoftargetcollagensequencesusingashortprobepeptide,Talanta,2017,第5作者
(11)NMRSpec:Anintegratedsoftwarepackageforprocessingandanalyzingonedimensionalnuclearmagneticresonancespectra,ChemometrIntellLab,2017,通讯作者
(12)Specificpatternsofspinalmetabolitesunderlyingalpha-Me-5-HT-evokedprurituscomparedwithhistamineandcapsaicinassessedbyprotonnuclearmagneticresonancespectroscopy,BBA-MolBasisDis,2017,通讯作者
(13)Proteomicsandmetabolomicsanalysisofhepaticmitochondrialmetabolisminalcohol-preferringandnon-preferringrats,Oncotarget,2017,通讯作者
(14)EvaluationofmetabolitesextractionstrategiesforidentifyingdifferentbrainregionsandtheirrelationshipwithalcoholpreferenceandgenderdifferenceusingNMRmetabolomics,Talanta,2017,通讯作者
(15)DeterminationofHistaminebyHigh-PerformanceLiquidChromatographyAfterPrecolumnDerivatizationwitho-Phthalaldehyde-Sulfite,JournalofChromatographicScience,2016,通讯作者
(16)CompositionaldifferencesamongChinesesoysaucetypesstudiedbyC-13NMRspectroscopycoupledwithmultivariatestatisticalanalysis,Talanta,2016,第4作者
(17)Characterizationofcationicstarchflocculantssynthesizedbydryprocesswithballmillingactivatingmethod,IntJBiolMacromol,2016,第5作者
(18)CharacterizationandComparisonofCommercialChineseCerealandEuropeanGrapeVinegarsUsingH-1NMRSpectroscopyCombinedwithMultivariateAnalysis,中国化学(英文版),2016,第2作者
(19)HighMorphologicPlasticityofMicroglia/MacrophagesFollowingExperimentalIntracerebralHemorrhageinRats,IntJMolSci,2016,第4作者
(20)SimultaneousDeterminationofArginineandCitrullineinGourdFruitsandMelonsbyHighPerformanceLiquidChromatographywithElectrochemicalDetection,FoodAnalMethod,2016,第5作者
(21)DeterminationofWhitenersinCosmeticsbyMicrodialysisandHigh-PerformanceLiquidChromatography,AnalyticalLetters,2015,通讯作者
(22)Quantitativeproteomicsrevealsolfactoryinput-dependentalterationsinthemouseolfactorybulbproteome,JournalofProteomics,2014,通讯作者
(23)Oxidationofethanolintheratbrainandeffectsassociatedwithchronicethanolexposure,PNAS,2013,第1作者
(24)Metabolicproductsof[2-13C]Ethanolintheratbrainafterchronicethanolexposure,JournalofNeurochemistry,2013,第1作者
(25)DifferentialroleofventraltegmentalareaacetylcholineandN-methyl-D-aspartatereceptorsincocaine-seeking,Neuropharmacology,2013,第4作者
(26)Amyloid-betaDepositionandOlfactoryDysfunctioninanAlzheimer’sDiseaseModel,JournalofAlzheimer’sDisease,2013,第4作者
(27)Anethanolvaporchamberforsmallanimals,Alcoholism:ClinicalandExperimentalResearch,2012,第1作者
(28)Metabolicproductsof[1-13C]ethanolintheawakeratbrain,Alcoholism:ClinicalandExperimentalResearch,2012,第1作者
(29)Anethanolvaporchambersystemforsmallanimals,JournalofNeuroscienceMethods,2012,第1作者
(30)大脑能量代谢和神经传递动力学的NMR测定方法,NMRmethodfordeterminingenergymetabolismandneurotransmissionkineticsinbrain,ChineseJournalofMagneticResonance,2010,第1作者
(31)Regionalmetabolitelevelsandturnoverintheawakeratbrainundertheinfluenceofnicotine,JournalofNeurochemistry,2010,第1作者
(32)Quantitativestructure-retentionrelationshipsmodelsforthepredictionofthereversed-phaseHPLCgradientretentionbasedontheHeuristicMethodandSupportVectorMachine,JournalofChromatographicScience,2009,第2作者
(33)Predictionofrelativesensitivityoftheolfactoryandnasaltrigeminalchemosensorysystemsforaseriesofthevolatileorganiccompoundsbasedonlocallazyregressionmethod,SensorsandActuatorsB:Chemical,2009,第2作者
(34)ClassificationStructureActivityRelationship(CSAR)StudiesforPredictionofGenotoxicityofThiopheneDerivatives,ToxicologyLetters,2008,第2作者
(35)PredictionofretentiontimesofpeptidesinRPLCbyusingradialbasisfunctionneuralnetworksandprojectionpursuitregression,ChemometricsandIntelligentLaboratorySystems,2008,第2作者
(36)QuantitativeStructureActivityRelationship(QSAR)StudiesforPredictionoftheInhibitionofMatrixMetalloproteinaseInhibitorsBasedontheCombinationofProjectionPursuitRegressionandGridSearchmethod,ChemometricsandIntelligentLaboratorySystems,2008,第2作者
(37)QuantitativeStructure-RetentionRelationshipstudyoftheconstituentsofsaffronaromainSPME-GC-MSbasedontheProjectionPursuitRegressionmethod,Talanta,2008,第2作者
(38)Anovelquantitativestructure-activityrelationshipmethodtopredicttheaffinitiesofMT3melatoninbindingsite,EuropeanJournalofMedicinalChemistry,2008,第2作者
(39)Predictionoffungicidalactivitiesofriceblastdiseasebasedonleastsquaressupportvectormachinesandprojectpursuitregression,JournalofAgriculturalandFoodChemistry,2008,第2作者
(40)Novelapproachestopredicttheretentionofhistidine-containingpeptidesinimmobilizedmetal-affinitychromatography,Proteomics,2008,第3作者
(41)Predictionofretentionindicesofdrugsbasedonimmobilizedartificialmembranechromatographybyusingprojectionpursuitregressionandlocallazyregression,JournalofSeparationScience,2008,第3作者
(42)UsingClassificationStructurePharmacokineticRelationship(CSPR)methodtoPredictDrugBioavailabilityBasedonGrid-SearchSupportVectorMachine,AnalyticaChimicaActa,2007,第1作者
(43)PredictionofSurfaceTensionforCommonCompoundsBasedonNovelMethodsUsingHeuristicMethodandSupportVectorMachine,Talanta,2007,第1作者
(44)StudyontheStructure-ActivityRelationshipofNewAnti-HIVNucleosideDerivativesBasedontheSupportVectorMachineMethod,QSARandCombinatorialScience,2007,第1作者
(45)QuantitativeStructure-ActivityRelationshipstudyonaseriesofnovelligandsbindingtocentralbenzodiazepinereceptorbyusingthecombinationofHeuristicMethodandSupportVectorMachines,QSARandCombinatorialScience,2007,第3作者
(46)PredictionofthePowerRotationoftheAminoAcidBasedontheQuantitativeStructure-PropertyRelationshipMethod,ChineseJournalofAnalyticalChemistry,2006,第1作者