研究领域
（1）光动力新药研发及光动力疗法的基础与应用研究（如抗肿瘤、抗鲜红斑痣、抗类风湿性关节炎、抗病毒作用等）。
（2）心血管疾病与肿瘤防治分子靶向药物研究（如血管紧张素受体拮抗剂类新药的设计、合成及其降压、抗心衰、预防老年痴呆及抗肿瘤作用研究；叶酸、多肽导向的新药分子研究）。
（3）药物纳米靶向载体研究（如磁靶向药物纳米载体与纳米传递系统研究）。
（4）功能医药材料与试剂研制（如抗肿瘤膜、抗再狭窄人造血管、新型抗菌防霉剂等）。
（5）天然活性产物及中药现代化研究。
近期论文
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1. Ya-jing Da, Wei-dong Yuan, Ting Xin, Yong-yan Nie, Ying Ye, Yi-Jia Yan, Li-sha Liang, Zhi-long Chen*. Synthesis and biological evaluation of new fluorine substituted derivatives as angiotensin II receptor antagonists with anti-hypertension and anti-tumor effects. Bioorganic & Medicinal Chemistry. 2012, 20(14): 7101-7111.
2. Yong-yan Nie, Ya-jing Da, Hao Zheng, Lin Jia, Cai-hong Wen, Li-sha Liang, Juan Tian, Zhi-long Chen*. Synthesis and biological evaluation of novel potent angiotensin II receptor antagonists with anti-hypertension effect. Bioorganic & Medicinal Chemistry. 2012, 20(8):2747-2761.
3. Yi-jia Yan, Mei-zhen Zheng, Zhi-long Chen*, Xin-hai Yu, Xiao-xia Yang, Zhi-lou Ding, Li Xu. Studies on preparation and photodynamic mechanism of chlorin P6-13, 15-N-(cyclohexyl)cycloimide (Chlorin-H) and its anti-tumor effect for photodynamic therapy in vitro and in vivo. Bioorganic & Medicinal Chemistry, 2010, 18(17): 6282-6291.
4. Mao Hui-jing , Chen Zhi-long*, and Ye Ying. The photophysical properties of pyropheophorbide-a in different laser light and PDT efficiency for eca-109 cell in vitro. Advanced Materials Research, 2012, 393-395: 1029- 1032.
5. Ya-jing Da, Dan Wu, Ling-Feng Zhu, Zhi-long Chen*. Synthesis, Anti-hypertensive effect of a novel angiotensin II AT 1 receptor antagonist and its antitumor activity in prostate cancer. Arzneimittel-Forschung (Drug Research), 2012; 62: 637– 643.
6. Hai-ming Wu, Na Chen, Zhong-Ming Wu, Zhi-Long Chen and Yi-Jia Yan. Preparation of photosensitizer-loaded PLLA nanofibers and its anti-tumor effect for photodynamic therapy in vitro. Journal of Biomaterials Applications. 2013, 27(6): 773-779.
7. Yun Sun, Zhi-Long Chen*, et al. Magnetic chitosan nanoparticles as drug delivery system for targeting photodynamic therapy. Nanotechnology, 2009, 20 (13): 135102 (8 pp). (Highlighted).
8. Zhi-Long Chen, Yun Sun, et al. Studies on preparation of photosensitizer loaded magnetic silica nanoparticles and their antitumor effects for targeting photodynamic therapy, Nanoscale Research Letters, 2009, 4, 400-408 。
9. Shuqing Lv, Jianmin Yang, Zhilong Chen,et al. Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. Experimental Hematology. 2009, 37(7): 831-837.
10. Fuxian Liu, Xingping Zhou, Zhilong Chen, et al. Preparation and properties of photosensitizer loaded magnetic nanocomposites, Current Nanoscience, 2009, 5(3): 293-296.
11.Shuqing Lv, Zhilong Chen, Jianmin Yang, et al. Overexpression of the PSMB5 gene contributes to bortzomib resistance in T-lympoblastic lymphoma/ leukemia cells derived from Jurkat line. Experimental Hematology, 2008, 36 (10): 1278-1284.
12、Deng Kui, Chen Zhi-Long, et al. Studies on the photodynamic mechanism of tetrapyrrole compounds laser flash photolysis. Chinese Journal of Chemistry. 2008, 26(1): 202-207.
13. Xingping Zhou, Zhilong Chen, et al. Luminescence Stability of the Silica Encapsulated CdSe Nanoparticles. Current Nanoscience, 2008, 4(1): 88-91
14. Zhi - Long Chen, Ronald N. Warrener and Douglas N. Butler. The preparation of 1, 2 - bis ( 2, 2’: 6’, 2’’ - terpyridin - 4’ yl ) ethanone: the first example of 4’ - terpyridyls unsymmetrically linked by a functionalized two-carbon chain. Australian Journal of Chemistry, 2004, 57 ( 7 ): 689- 692.
15、Yi - Kang Wu, Xin Shen, Zhi - Long Chen, et al. Synthesis of natural fragrant molecules cis - 3 - methyl - 4 - decanolide and aerangis lactone. General enantioselective routes to cis - disubstituted- lactones and cis - disubstituted- lactones. Journal of Organic Chemistry, 2002, 67 (11): 3802 - 3810.
16、Ronald N. Warrener, Davor Margetic, David A. Mann, Zhi-Long Chen,et al. Novel Geometry Polynorbornane Scaffolds for Chromophore Linkage and Spacing. Artificial Photosynthesis: From Basic to Industrial Application. Edited by Anthony F. Collings and Christa Critchley. Copyright @ 2005 Wiley-Verlag GmbH & Co. KgaA, Weinheim. 2005. Page 147-166.
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