肖庚富 - 中国科学院大学

个人简介

招生专业 071010-生物化学与分子生物学 071005-微生物学招生方向病毒生物化学病毒学教育背景 1995-09--武汉大学理学博士 1989-09--同济医科大学医学硕士 1984-09--同济医科大学医学学士工作简历 1995-09~现在, 武汉大学, 理学博士 1989-09~现在, 同济医科大学, 医学硕士 1984-09~现在, 同济医科大学, 医学学士教授课程分子病毒学奖励信息（1）国务院政府特殊津贴, 一等奖, 国家级, 2018 专利成果（ 1 ）呼吸道合胞病毒F蛋白与Fc的融合蛋白及其用途, 2014, 第 1 作者, 专利号: ZL 201310090044.3 （ 2 ）穿梭质粒载体及其构建方法和应用, 2016, 第 1 作者, 专利号: CN104087610A （ 3 ）乌本苷在制备治疗哺乳动物黄病毒科病毒感染的药物中的应用, 2019, 第 2 作者, 专利号: CN201810731405.0 发表著作（ 1 ）基因工程, Gene engineering, 科学出版社, 2004-04, 第 2 作者科研项目（ 1 ）病毒侵染过程的时空诠释, 主持, 国家级, 2011-01--2015-12 （ 2 ）重要病毒的入侵抑制, 主持, 国家级, 2010-01--2014-08 （ 3 ）朊病毒转录调控机制, 主持, 国家级, 2012-01--2015-12 （ 4 ）朊病毒导致神经疾病机制, 主持, 国家级, 2011-01--2013-12 （ 5 ）重要新发突发病毒宿主适应与损伤机制研究, 主持, 国家级, 2016-06--2019-06 （ 6 ） **病毒**糖基化位点改造提高抗原和抗体活性（国防）, 主持, 部委级, 2015-10--2017-10 （ 7 ）烈性病毒抗血清制备, 主持, 部委级, 2016-01--2018-12 （ 8 ） **应急免疫快速评价技术（非公开）, 主持, 国家级, 2016-07--2019-06 （ 9 ） 2019-nCoV的保护性抗体、疫苗研发和药物筛选与评价研究, 主持, 国家级, 2020-02--2020-12 （ 10 ）湖北省新型肺炎应急科技攻关项目, 主持, 省级, 2020-02--2021-12 （ 11 ）非公开, 主持, 部委级, 2019-01--2020-12

近期论文

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（1） Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junín virus., Antiviral Res., 2020, 通讯作者（2） Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection., Antimicrob Agents Chemother., 2020, 通讯作者（3） Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes., Emerg Microbes Infect., 2020, 第 8 作者（4） A pneumonia outbreak associated with a new coronavirus of probable bat origin., Nature., 2020, 其他（合作组作者）（5） Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro., Cell Res., 2020, 通讯作者（6） Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2., Protein Cell., 2019, 第 10 作者（7） A novel RSV F-Fc fusion protein vaccine reduces lung injury induced by respiratory syncytial virus infection., Antiviral Res., 2019, 通讯作者（8） Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection., J Virol., 2019, 第 6 作者（9） Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein., J Virol., 2019, 通讯作者（10） A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells., Molecules., 2019, 通讯作者（11） Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality., Cell Res., 2019, 其他（合作组作者）（12） Novel neutralizing monoclonal antibodies against Junin virus., Antiviral Res., 2018, 通讯作者（13） Fungal mannosylation enhances human papillomavirus 16 E7 therapeutic immunity against TC-1 tumors., Oncol Rep., 2018, 通讯作者（14） Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection., J Virol., 2017, 通讯作者（15） FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection, J Virol., 2017, 第 6 作者（16） Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus., J Virol., 2016, 通讯作者（17） Roles of methionine oxidation in E200K prion protein misfolding: Implications for the mechanism of pathogenesis in E200K linked familial Creutzfeldt-Jakob disease, Biochim Biophys Acta, 2016, 通讯作者（18） Assembly of long DNA sequences using a new synthetic Escherichia coli-yeast shuttle vector, Virol Sin, 2016, 通讯作者（19） Structure-based mutational analysis of several sites in the e protein: implications for understanding the entry mechanism of Japanese encephalitis virus, J Virol., 2015, 通讯作者（20） Characterization of the fusion core in zebrafish endogenous retroviral envelope protein, Biochem Biophys Res Commun., 2015, 通讯作者（21） Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection, Biochim Biophys Acta., 2015, 通讯作者（22） Peptide inhibitor of Japanese encephalitis virus infection targeting envelope protein domain III, Antiviral Res., 2014, 通讯作者（23） Real-time quantitative PCR assay for rapid detection of murine virus contamination in bioproducts., Virol Sin., 2014, 通讯作者（24） Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein, Biochim Biophys Acta., 2014, 通讯作者（25） Japanese encephalitis virus activates autophagy as a viral immune evasion strategy., PLoS One. , 2013, 通讯作者（26） Conformational conversion of prion protein in prion diseases., Acta Biochim Biophys Sin, 2013, 通讯作者（27） Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis. , J Proteome Res. , 2013, 通讯作者（28） IGF-1-induced enhancement of PRNP expression depends on the negative regulation of transcription factor FOXO3a., PLoS One. , 2013, 通讯作者（29） PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP(51-136) region containing octapeptide repeats, Biochem Biophys Res Commun., 2012, 通讯作者（30） A Hsp40 chaperone protein interacts with and modulates the cellular distribution of the primase protein of human cytomegalovirus., PLoS Pathog., 2012, 通讯作者（31） Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin, J Virol. , 2011, 通讯作者（32） Blocking peptides against HBV: preS1protein selected from a phage display library, Biochem Biophys Res Commun., 2011, 通讯作者（33） Bioluminescence in-vivo imaging technology and its application in the study of viral infection--a review, Wei Sheng Wu Xue Bao, 2011, 通讯作者（34） Total chemical synthesis, assembly of human torque teno virus genome, Virol Sin., 2011, 通讯作者（35） Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein, Talanta, 2011, 第 4 作者（36） Reticulon 3 attenuates the clearance of cytosolicprion aggregates by inhibiting autophagy, Autophagy, 2011, 通讯作者（37） Clathrin-Mediated Endocytosis in Living Host Cells Visualized through Quantum Dot Labeling of Infectious Hematopoietic Necrosis Virus, J Virol., 2011, 通讯作者（38） Macromolecular crowding converts the human recombinant PrPC to the soluble neurotoxic beta-oligomers. , FASEB J. , 2010, 通讯作者（39） PEG-interspersed nitrilotriacetic acid-functionalized quantum dots forsite-specific labeling of prion proteins expressed on cell surfaces. , Biomaterials., 2010, 通讯作者（40） Real-time visualization of prion transport in single live cells using quantum dots. , Biochem Biophys Res Commun. , 2010, 通讯作者（41） Calnexin inhibits thermal aggregation and neurotoxicity of prion protein. , J Cell Biochem. , 2010, 通讯作者（42） Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment. , J Cell Biochem. , 2010, 通讯作者（43） A new method for the detection of the H5 influenza virus by magnetic beads capturing quantum dot fluorescent signals. , Biotechnol Lett. , 2010, 通讯作者

学术兼职

2018-05-08-今,国家重点研发计划“蛋白质机器”重点专项总体专家组, 成员